Relationship Between Serum Macrophage Migration Inhibitory Factor Level and Insulin Resistance,High-Sensitivity C-Reactive Protein and Visceral Fat Mass in Prediabetes

Background

Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass.

神经电生理检查在糖尿病前期周围神经病变的应用进展

糖尿病前期周围神经病的早期诊断重点依赖于对小纤维的评价.传统的神经传导检测只能反映大的有髓纤维的功能,而对于与痛觉及自主神经病变有关的小纤维病变缺乏敏感性.近年来随着神经电生理诊断技术的发展,糖尿病前期周围神经病的早期诊断不断提高.临床中常用小纤维病变的检测方法主要包括皮肤交感反应、定量感觉检查、接触性热痛诱发电位及定量催汗轴突反射等.就糖尿病前期周围神经病的发病机制、神经功能的病理学改变及神经电生理技术在糖尿病前期周围神经病变的应用进展加以综述,旨在为糖尿病前期周围神经病变的早期诊断提供客观依据.     

惠州市2型糖尿病流行病学调查

摘 要 目的:探讨惠州市2型糖尿病患病率及特点,调查糖尿患者用药情况,为制定本地区2型糖尿病防治工作重点提供科学依据。方法：采用分层整群抽样方法,对惠州市常住人群采用问卷调查方式收集资料,同时调查对象均接受空腹血糖、餐后2 h血糖、糖化血红蛋白、口服100 g馒头餐耐量试验等测定。结果：4 401人中已诊断2型糖尿病者95人,口服100 g馒头餐耐量试验结果阳性者后得到最终2型糖尿病患者274人,患病率为6.23%,在所有糖尿患者中,新诊断的2型糖尿病占65.33%。而在已诊断2型糖尿病患者中,未用药或未规范用药患者比例较大,患者使用口服药较多。结论：惠州市城乡居民2型糖尿病患病率与全国糖尿病患病率相比较低,用药习惯受传统文化影响。     

A review of the economic evidence for acarbose in the prevention of diabetes and cardiovascular events in individuals with impaired glucose tolerance

The highly prevalent, prediabetic condition of impaired glucose tolerance (IGT) confers a high risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). There is an emerging body of cost-effectiveness literature in the management of IGT. For acarbose, an alpha-glucosidase inhibitor, economic analyses have been conducted for Spain, Germany, Sweden and Canada. In Spain, acarbose was more effective and less costly (dominant) compared with placebo. In Germany, the cost per patient free of diabetes was under Pounds 800; acarbose was dominant for those at high risk for T2DM, CVD or both, and a similar outcome in the Swedish study. In Canada, acarbose was dominant compared with no intervention and very cost-effective compared with metformin [C Dollars 1798/life years gained (LYG)]. The particularly cost-effective outcomes or cost savings delivered by acarbose for IGT subjects at high risk for T2DM and/or CVD render an IGT-intervention program prioritised to such high-risk individuals an economically attractive strategy.     

中医治疗糖尿病前期的研究进展

糖尿病前期(Prediabetes Mellitus,PDM)又称为糖调节受损(Impaired sugar regulation,IGR),是正常糖代谢发展到糖尿病的一个过渡阶段,具有不稳定性和可逆性,包括空腹血糖受损(Impaired Fasting Glucose,IFG)、糖耐量低减(Impaired Gluc...     

Serum fucose levels in diabetic patients

Summary The total serum fucose level in diabetic patients is slightly increased in comparison with normal healthy subjects, mainly due to the presence of non protein-bound fucose. The serum fucose content after glucose loading does not show any difference between controls and potential diabetics (prediabetics). The determination of total serum fucose in patients with hyperglycemia may be complicated by the elevated blood glucose and it is necessary to use the method of internal standardization to avoid a possible error.This work was presented at the 6th Annual Meeting of the European Association for the Study of Diabetes, Warsaw, September 1970.     

Pharmacotherapeutic options for prediabetes

ABSTRACT

Introduction

‘Prediabetes’ is a condition of elevated glucose not attaining the established criteria for a diagnosis of diabetes. The United States Diabetes Prevention Program (DPP) began in 1996 and was the iconic study of prediabetes. In that study, after 3 years, the risk of reaching the numerical criteria of diabetes was reduced by 58% by intensive emphasis on diet and exercise whereas treatment with metformin achieved a lesser reduction of 31%. The DPP was widely heralded as suggesting that lifestyle change was superior to pharmacologic therapy in the prediabetes population. This conclusion may be overreaching in terms of the long-term results of that study.     

A new formula to improve the screening of impaired glucose tolerance in youths with overweight or obesity

AimTo assess a new formula to improve the screening of isolated impaired glucose tolerance (IGT) in youth with overweight/obesity (OW/OB).Methods and resultsA cross-sectional study was performed in 1189 Caucasian youths with OW/OB aged 5–17 years, in whom impaired fasting glucose and high glycosylated hemoglobin were excluded. The sample was divided into training set (TS) (n = 883) and validation set (VS) (n = 306). Fasting (FG) and post-load plasma glucose, alanine aminotransferase (ALT), lipids and familial history for type 2 diabetes (FD) were available in all individuals. In the TS youths with IGT (n = 58, 7.0%) showed higher prevalence of female sex (FS), FD, and higher levels of FG, post-load glucose, ALT and lower levels of HDL-cholesterol vs individuals without IGT. The linear formula was obtained by logistic regression analysis in the TS: 0.051ALT + 0.071FG + 0.871FD + (0.061HDL1 ? 1) + 11FS. The best cut-off was 5.84. The performance of the formula vs IGT was: sensitivity: 0.74 and specificity: 0.71. Similar results were obtained in the VS.ConclusionsUsing metabolic and anamnestic data we obtained a simple formula with a good performance for screening isolated IGT. This formula may support pediatricians to identify youths with OW/OB in whom the OGTT may be useful for detecting IGT.