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81.
Nailya Bulatova Violet Kasabri Amenah Qotineh Taiba AL-Athami Al-Motassem Yousef Salah AbuRuz Munther Momani Aymen Zayed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):257-267
Background
Targeting biomarkers of oxidative-proinflammatory stress may result in improvement of modifiable metabolic syndrome, pre-diabetes and diabetes risk factors and subsequent risk reduction.Methods
64 newly diagnosed antihyperglycemic treatment-naïve prediabetic and type 2 diabetes mellitus (T2DM) patients were randomly assigned using block design to either metformin combined with therapeutic lifestyle changes (TLC) or TLC alone. Body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting lipid profile, plasma oxidative status and tumor necrosis factor (TNF)-α were measured at baseline, after 3 months and after 6 months from baseline.Results
Except for HbA1c, baseline values did not differ significantly between the two groups. The post 3-months relative reductions in BMI (P = 0.014) and HbA1c (P = 0.037) in metformin combined with TLC intervention were significantly greater than those in TLC alone group. TNFα plasma levels were decreased significantly vs. baseline by metformin combined with TLC intervention (?22.90 ± 46.76%, P = 0.01). Conversely, TLC alone basically worsened proinflammatory status (42.40 ± 40.82 %), P < 0.001. Metformin with TLC treatment effected a therapeutic decrement of the oxidative stress (?15.44 ± 35.32%, P = 0.029 vs. baseline) unlike TLC alone (61.49 ± 122.66%, P = 0.01 vs. baseline). Both interventions' effects were sustained in the 6-month follow up periods.Conclusion
In both intervention groups, the relative changes in plasma TNFα were significantly correlated (P < 0.01) with systolic blood pressure and the relative changes in oxidative stress were markedly correlated (P < 0.05) with total cholesterol. 相似文献82.
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86.
《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2019,13(1):396-400
IntroductionPrediabetes is a chronic low-grade inflammatory disease and considered as a risk factor for the development of diabetes mellitus and cardiovascular disease. Myeloperoxidase (MPO) is a leukocyte-derived enzyme, linked to both oxidative stress and inflammation and has been proposed as a possible mediator of atherosclerosis, the major cause of cardiovascular disease. The objective of the present study was to evaluate the level of MPO in prediabetic subjects and correlate it with other cardiovascular disease risk factors.Materials and methodsIn this cross-sectional study, a total of 400 subjects were recruited. Of them, 200 were prediabetic subjects and 200 were age and gender-matched controls. For each subject, blood pressure, weight, height, waist circumference, hip circumference and lipid parameters were measured. In addition, MPO was determined.ResultsMPO was significantly increased in prediabetic subjects as compared to controls. In correlation analysis, MPO was found to be significantly and positively correlated with all the cardiovascular disease risk factors i.e. age, body mass index (BMI), waist-to-hip ratio (WHR), blood pressure [both systolic blood pressure (SBP) and diastolic blood pressure (DBP)], lipid parameters except high density lipoprotein (HDL) to which it was negatively correlated.ConclusionIn conclusion, MPO is well correlated with cardiovascular disease risk factors in prediabetes. Hence, MPO could be used to detect cardiovascular risk among prediabetic subjects and also can be used as an early biomarker of oxidative stress and inflammation in prediabetes. 相似文献
87.
《Nutrition, metabolism, and cardiovascular diseases : NMCD》2014,24(6):670-676
Background and aimsWe aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia.Methods and resultsNinety-one subjects with prediabetes according to HbA1c, i.e. from 5.7 to 6.4% (39–46 mmol/mol), 50 newly diagnosed patients with HbA1c-defined type 2 diabetes (HbA1c ≥6.5% [≥48 mmol/mol]), and 67 controls with HbA1c lower than 5.7% (<39 mmol/mol), were studied. Fasting blood samples for lipid profiles, fatty liver index (FLI), bioimpedance analysis, ultrasound scan of the liver, and BARD (body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes) score for evaluation of liver fibrosis, were performed in all subjects. In comparison to controls, subjects with prediabetes were characterised by: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure, triglycerides levels and apolipoprotein B/apolipoprotein AI ratio, higher FLI, increased prevalence of and more severe hepatic steatosis, similar BARD score, and higher total body fat mass. In comparison to subjects with diabetes, subjects with prediabetes exhibited: similar blood pressure and apolipoprotein B/apolipoprotein AI ratio, similar FLI, reduced prevalence of and less severe hepatic steatosis, lower BARD score, increased percent fat and lower total body muscle mass. In comparison to controls, subjects with diabetes showed: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure and triglycerides levels, higher FLI, increased prevalence of and more severe hepatic steatosis, higher BARD score, and higher total body muscle mass. Moreover, HbA1c was correlated with BMI, HOMA-IR, triglycerides, HDL cholesterol, AST, and ALT.ConclusionsSubjects with HbA1c-defined prediabetes and type 2 diabetes, respectively, are characterised by abnormalities in lipid profile and liver steatosis, thus exhibiting a severe risk profile for cardiovascular and liver diseases. 相似文献
88.
Kristian Rett 《Current medical research and opinion》2013,29(9):1529-1534
Prediabetes is defined as a state of abnormal glucose homeostasis where blood glucose levels are elevated above those considered normal, but not as high as those required for a diagnosis of diabetes. As a condition intermediate between normal glucose homeostasis and the pathological condition of diabetes, the characterization of prediabetes as a distinct pathogenic condition is controversial. Emerging evidence suggests that the condition of prediabetes is associated with pathophysiological changes in several tissues and organs, which would support its recognition as a distinct pathological entity; the recent inclusion of prediabetes and associated billable conditions in the most recent ICD-10 codes provides additional credence to this position. This minireview summarizes our understanding of prediabetes and provides evidence that it should be considered a distinct and important clinical entity. 相似文献
89.
S.V. Madhu G. Sandeep B.K. Mishra M. Aslam 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):923-927
Aim
The burden of diabetes is very high in our country particularly in the urban metros. The present survey was planned to ascertain the current prevalence of diabetes and prediabetes in Delhi since the available prevalence estimates are over a decade old.Methods
The present study was conducted in urban area of east Delhi and followed a multistage random sampling design. The prevalence of known diabetes was ascertained based on self reporting and prevalence of newly detected diabetes and prediabetes was based on oral glucose tolerance test (OGTT).Results
We surveyed 470 households and included 1317 individuals. Prevalence of diabetes was 18.3% (known 10.8% and newly detected 7.5%). Prevalence of prediabetes was 21% as per WHO criteria and 39.5% as per ADA criteria. The ratio of known to unknown diabetes was 1.44:1. Every third household (35.77%) had at least one known case of diabetes. High rates of obesity and central obesity were also observed in the study population.Conclusion
The present study found a strikingly high prevalence of diabetes, prediabetes and obesity in Delhi. This calls for urgent and effective preventive measures to prevent diabetes. 相似文献90.
Janette D. Bigelow-Sherman Kenji Shima E. Keith Borden Richard Penhallegon Piero P. Foà 《Acta diabetologica》1970,7(1):68-92
Summary Glucose, free fatty acids and immunoreactive insulin levels were measured in 323 normal, potentially diabetic and diabetic subjects after an oral glucose load and an intravenous injection of tolbutamide. The results indicate that, in potentially diabetic and diabetic subjects, the insulinogenic response to glucose lasted longer than in normal subjects. It is suggested that this phenomenon be due to the loss of cell sensitivity to the recently demonstrated inhibitory feedback induced by insulin itself. The insulinogenic response to tolbutamide and the FFA response to tolbutamide and insulin did not help in differentiating prediabetic from normal subjects. No consistent relationship was found between body weight and serum insulin response to glucose.This work was aided by Grant No. AM 06034 from the National Institutes of Health and by a Grant from the Upjohn Company. 相似文献