冠心病高危因素对PCI术的影响及预后效果研究

目的 探讨冠心病患者经皮冠状动脉介入术(PCI)的高危因素及其对患者预后的影响,为临床治疗提供参考依据.方法 回顾性分析2014年9月至2016年11月期间于北京武警总医院心血管内科诊治的384例冠心病患者的临床资料,对患者的疾病临床资料和相关血液生化指标进行高危因素和多因素Logistic回归分析,PCI术后随访3个月,统计患者的心脏不良事件(MACE)和死亡情况.结果 ①术后随访3个月,384例PCI术后患者中有65例发生MACE,发生率为16.93％,其中主要MACE为心衰、心绞痛、心梗复发、再次PCI及心源性死亡;②MACE组和非MACE组患者的高密度脂蛋白(HDL-C)[(1.27±0.84)mmol/L vs(1.67±0.96)mmol/L]、低密度脂蛋白(LDL-C)[(2.72±0.33)mmol/L vs(2.11±0.24)mmol/L]、总胆固醇(TC)[(4.42±1.81)mmol/L vs(4.03±1.79)mmol/L]、甘油三酯(TG)[(1.79±0.63)mmol/L vs(1.52±0.46)mmol/L],超敏C反应蛋白(hs-CRP)[(4.82±0.78)mg/L vs(4.61±0.35)mg/L],糖化血红蛋白(HbAlc)[(6.94±1.02)mmol/L vs(6.32±1.14)mmol/L],肌钙蛋白I(cTNI)[(0.06±0.01)mmol/L vs(0.18±0.05)mmol/L]比较差异均有统计学意义(P<0.05);③多因素Logistic回归分析结果显示,高龄、吸烟史、合并高血压、糖尿病和高脂血症、PCI支架安装个数及HDL-C、LDL-C、TC、TG、hs-CRP、HbAlc、cTNI是PCI术预后的影响因素(P<0.05).结论 冠心病患者存在的高危因素较多,能够直接影响PCI术后患者的治疗效果,临床工作中应在PCI术前进行相关高危因素筛查,选择积极的控制措施,减少心脏不良事件的发生.     

综合护理干预对经皮冠状动脉介入治疗患者焦虑与抑郁及心理自评状况的影响

【摘要】目的 研究综合护理干预对经皮冠状动脉介入治疗患者焦虑、抑郁及心理自评状况的影响。方法 收集我院心血管内科2013年1月~2015年1月收治的的100例将行经皮冠状动脉介入治疗冠心病患者,随机分为对照组（50例）和实验组（50例）,在PCI术前均进行焦虑自评量表（SAS）、抑郁自评量表（SDS）和症状自评量表(SCL-90)测评,对照组行常规基础护理,实验组在常规基础护理上再行综合护理干预,术后再次对100例患者实行心理测评,最后将患者的术前测评和术后测评进行对比分析。结果 干预前实验组和对照组的SAS、SDS和SCL 90三类测评数值均大于各类检测评分的阈值,两组间比较,差异不具有统计学意义（P>0.05）;进行综合护理干预之后,实验组的SAS、SDS、SCL-90的评分明显较干预前低,对照组的SAS、SDS和SCL-90的评分明显较干预前高。干预后对照组SAS、SDS、SCL-90的评分明显高于实验组,差异均有统计学意义（P<0.05）。结论 冠心病患者行PCI治疗存在焦虑、抑郁等不良情绪,综合护理干预对经皮冠状动脉介入治疗患者焦虑、抑郁及心理自评状况具有改善效果,可在临床应用和推广     

PCI术后患者服用氯吡格雷依从性调查分析

【】 目的：探讨PCI术后患者服用氯吡格雷的依从性及其影响因素。方法:选取2015年5月至10月在某三甲医院成功实施PCI术后6个月服用氯吡格雷的患者91例 。采取电话随访的方式进行调查,评估患者术后6个月服用氯吡格雷药物的依从性及其影响因素。所得数据均采用SPSS18.0统计软件进行统计学处理。结果:在本次对91例PCI术后患者服用氯吡格雷依从性调查显示：有55例(60.4%)患者术后氯吡格雷依从性良好,有36例(39.4%)患者依从性差;在对影响患者服用氯吡格雷依从性相关因素的分析中显示：PCI术后患者性别(P=0.131)与依从性无显著相关性;PCI术后患者年龄(P=0.002),合并疾病(P=0.000),医疗付费方式(P=0.000)与患者服用氯吡格雷依从性有相关性。结论：PCI术后患者服用氯吡格雷依从性还有待提高;服用氯吡格雷药物依从性与患者的性别无关,而与患者的年龄、合并疾病、医疗付费方式有相关性。     

通心络对急性冠脉综合征患者PCI术后炎性反应及血管内皮功能的影响

 目的 探讨通心络对急性冠脉综合征(acute coronary syndrome, ACS)患者PCI术后炎性反应及血管内皮功能的影响。方法 收集辽河油田总医院心内科2017-10至2018-03收治的拟行PCI治疗的ACS住院患者137例,以随机信封法分为通心络组(68例)和对照组(69例)。对照组给予冠心病常规治疗,通心络组在常规治疗的基础上给予通心络胶囊口服治疗,观察周期均为12周。监测两组PCI术后血管生成素样蛋白2(Angptl2)、白细胞介素(IL)-18及血浆纤溶酶原激活物抑制剂-1(PAI-1)水平变化,术后12周肱动脉血管内皮舒张功能(FMD)和小动脉弹性指数(C2)。结果 观察治疗12周后,两组Angptl2[(27.61±8.55)ng/L,(32.30±11.56)ng/L]及IL-18[(75.66±10.22)pg/ml,(91.81±12.99)pg/ml]水平均较治疗前[(61.95±10.31)ng/L,(60.83±10.00)ng/L;(178.28±12.00)pg/ml,(180.12±10.43)pg/ml]显著降低(P＜0.05),同时PAI-1水平[(26.64±8.0)μg/L,(30.92±6.64)μg/L]较治疗前[(88.71±8.11) μg/L,(83.33±8.70) μg/L]显著降低(P＜0.05);且通心络组Angptl2及IL-18水平较对照组显著降低(P＜0.05);通心络组PAI-1水平低于对照组,两组间差异有统计学意义(P＜0.05)。治疗12周后两组FMD和C2均有改善,通心络组[FMD(8.99±1.12),C2(6.32±0.70) ml/mmHg×100]水平明显优于对照组[(6.65±0.95),(5.42±0.91)ml/mmHg×100]) (P＜0.05)。结论 通心络可通过降低Angptl2、IL-18、PAI-1水平及改善FMD和C2,减轻ACS患者PCI术后炎性反应、恢复血管内皮功能和修复小动脉弹性。     

Significance of laparoscopic cytoreductive surgery for appendiceal pseudomyxoma peritonei with limited disease and low tumor burden

ObjectiveTo investigate the clinical value of laparoscopic cytoreductive surgery (CRS) in treating of appendiceal pseudomyxoma peritonei with limited disease and low tumor burden.MethodsThe clinical data of patients with appendiceal pseudomyxoma peritonei treated by surgery with CRS at the Aerospace Center Hospital from January 2018 to December 2021 were retrospectively analyzed. The patients were divided into laparoscopic or open CRS groups according to the operation method. A propensity score-matched (PSM) analysis (1:1) was performed, the related clinical variables were compared between the two groups, and the effect on progression-free survival (PFS) was also analyzed.ResultsOne hundred and eight patients were included in this study. After PSM, 33 patients were selected from each group and the age and peritoneal cancer index were matched between the two groups. There were significant differences in operation time (P < 0.001), intraoperative bleeding (P < 0.001), intraoperative blood transfusion (P = 0.007), hospital stay (P < 0.001). The analysis of PFS showed that there was no significant difference between the two operation methods. After multivariate analysis, the pathologic subtype (P = 0.012) was identified as an independent prognostic factor for PFS.ConclusionThe curative effect of laparoscopic CRS is like that of open operation, which can significantly shorten the operation time and hospital stay and reduce intraoperative bleeding and blood transfusion event. The laparoscopic CRS is safe and feasible in strictly selected patients. The pathologic subtype is an independent factor affecting the prognosis for PFS.     

老年冠心病PCI术后患者心理弹性与自我管理行为相关性研究

目的 研究老年冠心病PCI(percutaneous transluminal coronary intervention)术后患者心理弹性与自我管理行为的相关性,为提升患者自我管理行为干预措施的制订提供参考。方法 采用分层随机方法抽取在本院接受PCI手术的老年冠心病患者185例,采用一般资料调查表、心理弹性量表(CD-RISC)、冠心病自我管理行为量表(CSMS)对研究对象进行问卷调查,评价其心理弹性水平和冠心病自我管理行为,并分析两者相关性。结果 185例冠心病PCI术后老年患者CD-RISC总分为(69.24±10.35)分,其中自强维度条目均分最高(2.91±0.48)分,其次为坚韧与控制(2.74±0.39)分、乐观(2.58±0.37)分;CSMS量表总分为(71.57±11.74)分,其中日常生活管理行为维度条目均分最高(2.79±0.36)分,其次为疾病医学管理行为(2.71±0.35)分、情绪管理行为(2.31±0.29)分。Pearson相关性分析显示,老年冠心病PCI术后患者心理弹性与自我管理行为呈正相关(r=0.792,P＜0.001)。结论 老年冠心病PCI术后患者心理弹性及自我管理行为能力较差,心理弹性与自我管理行为呈正相关关系,临床应重视该类患者心理干预,提升其自我管理行为。     

Preoperative and surveillance MR imaging of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy

MR imaging provides considerable advantages for imaging patients with peritoneal tumor. Its inherently superior contrast resolution compared to CT allows MRI to more accurately depict small peritoneal tumors that are often missed on other imaging tests. Combining different contrast mechanisms including diffusion-weighted (DW) MRI and gadolinium-enhanced MRI provides a powerful tool for preoperative and surveillance imaging in patients being considered for cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC).     

The Radial Artery for Percutaneous Coronary Procedures or Surgery?

This article summarizes the current research on the benefits of using the transradial approach for percutaneous procedures and the radial artery as a conduit for coronary artery bypass surgery. Based on the available evidence, the authors provide recommendations for the use of the radial artery in patients undergoing percutaneous or surgical coronary procedures.