农村慢性阻塞性肺疾病患者急性加重病因分析及防控体会

目的：分析农村慢性阻塞性肺疾病急性加重病因,加深对该疾病的认识及防控措施。方法：对慢性阻塞性肺疾病急性加重268例诱发因素及防控进行分析。结果：感染、劳累及情绪是引起慢性阻塞性肺疾病急性加重主要诱因。结论：有效地避免发病的高危因素、急性加重的诱发因素对防控慢性阻塞性肺疾病的发生及进展意义重大。     

中下面部线雕联合局部注射填充对皮肤状态及不良反应的影响

目的 探究在面部年轻化治疗中采用中下面部线雕联合局部注射填充的效果及对皮肤状态的影响。 方法 选取2021年1月-2024年1月于观山湖科珑小可美容诊所美容皮肤科行面部年轻化治疗的60例患者, 随机分为对照组和观察组,每组30例。对照组采用局部注射填充治疗,观察组采用中下面部线雕联合局 部注射填充治疗,比较两组皮肤状态、心理状态、生活质量及不良反应发生情况。结果 观察组术后皮 肤水分、弹性评分高于对照组,油脂、暗斑评分低于对照组（P ＜0.05）;观察组术后SAS、SDS评分均 低于对照组（P ＜0.05）;观察组术后生活质量各维度评分均高于对照组（P ＜0.05）;观察组不良反应发 生率为6.67%,低于对照组的30.00%（P＜0.05）。结论 中下面部线雕联合局部注射填充在面部年轻化中的 应用效果确切,抗衰效果及美学效果良好,可有效改善皮肤质地,减少皱纹,且治疗后不良反应较少,安 全性较高,有利于改善患者的心理状态及生活质量,值得临床应用。     

手术室护理干预在颌面外伤清创缝合术中的效果观察

目的 分析手术室护理干预在颌面外伤清创缝合术中的效果。方法 选取2023年1月-12月湖南中南 大学湘雅口腔医院行颌面外伤清创缝合术患者88例,随机分为对照组和观察组,每组44例。对照组接受常规 护理,观察组接受手术室护理干预,比较两组伤口Ⅰ期愈合情况、术中依从性、抑郁和焦虑程度、护理满 意度、并发症发生情况。结果 观察组伤口Ⅰ期愈合率为95.45%,高于对照组的72.73%（P＜0.05）; 观察组术中总依从率为97.73%,高于对照组的81.82%（P ＜0.05）;两组干预后SAS和SDS评分均低于干预 前,且观察组干预后SAS和SDS评分低于对照组（P ＜0.05）;观察组护理满意度各维度评分和总分均高于 对照组（P＜0.05）;观察组并发症发生率低于对照组（P ＜0.05）。结论 手术室护理干预能够促进颌面外 伤患者伤口愈合,缓解负性情绪,提高术中依从性,降低并发症发生率,且患者满意度较高。     

组织瓣修复口腔颌面部缺损的护理研究

口腔颌面部的外伤及恶性肿瘤等疾病会导致面部组织的缺损,对患者的美观度及功能等产生一定 的影响。组织瓣修复在改善患者口腔颌面部缺损以及外观上具有积极的临床效果,但其手术治疗效果与术 后护理具有密切的联系。本文对组织瓣移植进行概述,并对组织瓣修复口腔颌面部缺损的护理作一综述。     

Static and Fatigue Behaviour of Double-Lap Adhesive Joints and Notched Metal Samples Reinforced by Composite Overlays

The use of composite overlays to increase the fatigue life of notched steel samples is discussed in this paper. For such purposes, in the first set of studies, static and fatigue tests as well as the detailed analytical and numerical analyses for samples with double-lap joints were performed. Based on such studies, the shapes of the composite overlays were set. For a better understanding of the failure forms of the investigated adhesive joints, the experimental studies were monitored with the use of digital image correlation. In the second set of experimental studies, the static and fatigue tensile tests were performed for steel samples with a rectangular opening with rounded corners reinforced by composite overlays. The different shapes (square 45 × 45 mm and long stripes 180 × 15 mm) and composite materials (GFRP and CFRP) were used as overlays. The obtained improvement of fatigue life was in the range of 180–270% in the case of the rectangular overlays and 710% in the case of application of the overlays in the form of the long stripes. This was also confirmed by numerical analyses in which a reduction in the stress concentration factor from 2.508 (bare sample) through 2.014–2.183 (square 45 × 45 mm overlays) to 1.366 (overlays in the form of long stripes 180 × 15 mm) was observed.     

Evidence-Based Nutrition Interventions Improved Adolescents’ Knowledge and Behaviors in Indonesia

Adolescence is a nutritionally vulnerable and critical life stage. However, few programs and policies focus on improving adolescent nutrition in Indonesia. To address this gap, we implemented a gender-responsive package of interventions: (1) breakfast and weekly iron-folic acid supplementation (WIFS), (2) a school-based nutrition education program, and (3) a social behavior change communication strategy. We surveyed 514 adolescents at baseline (2019) and endline (2020) in Klaten and Lombok Barat districts in Indonesia. The survey included a knowledge assessment on nutrition, as well as indicators of attitudes and behaviors on diet, physical activity, and WIFS. We employed multivariable linear and logistic regression to test for pre–post intervention differences. Overall knowledge was significantly higher post-intervention (β: 3.3; 95% confidence interval [CI]: 2.6, 3.9). Diet diversity was high at both timepoints, however, at post-intervention there was significantly higher odds of consuming vitamin A-rich fruits and vegetables (Odds Ratio [OR]: 1.5; 95% CI: 1.1, 2.0) and lower odds of consuming sugar-sweetened beverages (OR: 0.4; 95% CI: 0.3, 0.5). Post-intervention, there was higher odds of reporting 60 min of daily physical activity (OR: 2.3; 95% CI: 1.7, 3.2) and WIFS among girls (OR: 6.7; 95% CI: 1.5, 30.9). The package of interventions may be a promising first step to improving adolescent nutrition in Indonesia.     

LINC00240 knockdown inhibits nasopharyngeal carcinoma progress by targeting miR‐26a‐5p

ObjectiveThis study intended to explore the regulatory functions of LINC00240 on nasopharyngeal carcinoma (NPC).MethodsMiR‐26a‐5p inhibitor, mimic, and siLINC00240 were transfected into NPC cells. QRT‐PCR was employed to assess miR‐26a‐5p and LINC00240 expressions. The targeting relationship of LINC00240 and miR‐26a‐5p was analyzed through dual luciferase reporter and RNA immunoprecipitation assay. Cell counting kit‐8 assay, colony formation assay, flow cytometry assay, wound healing assay, Transwell assay and in vitro angiogenesis assay were adopted for the evaluation of the effects of LINC00240 or miR‐26a‐5p and LINC00240 on NPC cells regarding cell proliferation, apoptosis and cycle, migration, invasion, and angiogenesis. EZH2, cell cycle, and epithelial‐mesenchymal transition (EMT)‐related protein expression was tested through Western blot.ResultsLINC00240 had a high expression in NPC tissues and cell lines. Silenced LINC00240 significantly suppressed the 5‐8F and HK1 cell proliferation, invasion, migration, and angiogenesis, but raised cell apoptosis, and cells were blocked in G0/G1 phase. MiR‐26a‐5p was a target of LINC00240. MiR‐26a‐5p upregulation suppressed the NPC cell proliferation, migration, invasion, angiogenesis, N‐cadherin and EZH2 expression, while it elevated apoptosis and p21, p27 and E‐cadherin expressions, whereas miR‐26a‐5p downregulation performed conversely. LINC00240 knockdown partially offset the effects of miR‐26a‐5p downregulation on cell proliferation, migration, invasion, angiogenesis, apoptosis, and EZH2.ConclusionLINC00240 knockdown restrained cell proliferation, invasion, migration, and angiogenesis, while it advanced apoptosis via miR‐26a‐5p in NPC by EZH2 inhibition.     

小牛血清蛋白提取物对家兔角膜碱烧伤治疗机制的研究

目的探讨小牛血清蛋白提取物（deproteinised calf blood extract,DCBE）对角膜碱烧伤的治疗作用机制。方法制作兔右眼碱烧伤模型,实验组、对照组和安慰组于烧伤后分别立即用20%小牛血清蛋白提取物、表皮生长因子和0.9%的生理盐水点眼,每日4次。分别于1、3、7、14天进行角膜荧光素钠染色照相后处死做常规HE染色病理切片和测定角膜的乳酸和丙酮酸含量。结果碱烧伤后第1、3、7、14天,实验组、对照组和空白组在角膜荧光素钠染色,HE病理染色及乳酸、丙酮酸有显著性差异。结论小牛血清蛋白提取物明显能抑制角膜碱烧伤后乳酸和丙酮酸的含量,进而促进碱烧伤后角膜的组织修复。     

传染病新特点与口岸卫生检疫应对

目的提高国境口岸应对传染病的新特点的能力。方法分析传染病新近出现新的特点和趋势,提出国境口岸卫生检疫的应对措施。结果应对传染病出现全球化、卷土重来的新特点,口岸卫生检疫工作任重道远,加强国际、国内、区域间及人医与兽医的合作,调整卫生检疫模式及内容,建立有效的防控体系。结论在传染病全球化和增多的情况下,建立有效的卫生检疫模式。     

体育运动常见的下肢关节韧带扭伤机理及防治

目的探讨体育运动中常见的下肢关节韧带扭伤机理及防治措施。方法对锦州师专体育系2003级和2004级学生共320人进行问卷调查,对320份有效问卷进行归纳总结并对数据进行统计和分析。结果排球、篮球、足球、跳高、跳远、跑步等运动项目中常出现踝关节韧带扭伤,排球、篮球、足球、体操、跳箱等运动项目中常出现膝关节韧带扭伤;出现扭伤后,2003级学生的处理方法对损伤恢复效果好于2004级学生,预防意识更强,措施更得当。结论踝关节和膝关节韧带扭伤是体育运动中常见的下肢关节韧带扭伤,它们与相关的运动项目有关;扭伤的机理除了与解剖结构、生理机能有关外,还与运动的技术动作,理论知识,实践经验,场地器械等有关;正确地处理和有效预防下肢关节韧带扭伤对促进身体健康和体育运动的开展有积极意义。