Wnt-frizzled信号通路与心血管疾病关系的研究进展

Many researches have focused on the wnt- frizzled cascade in the recent years, while much work has been done in neoplastic diseases and embryology, the role of the wnt- frizzled signal transduction pathway in cardiovascular diseases has only recently begun to be explored. It plays a very important role in many physiological and pathophysiological processes, such as its transduction pathway, the healing after myocardial infarction, the proliferation, differentiation and orientation of cardiomyocytes, angiogenesis/neovascularization, cardiac hypertrophy and heart failure, the deposition of the extracellular matrix and so on. This article is aimed at its relation with myocardial infarction and the role of this pathway in cardiovascular diseases.     

计算机自动定量诊断脑萎缩的初步研究

目的研究正常人群脑容积随年龄及性别的变化规律,提出计算机定量诊断脑萎缩的客观标准。方法利用最新提出的脑容积计算机自动定量算法,测量了脑萎缩组487例(男,310例,女,177例)和正常组1901例(男,993例,女,908例)的颅腔容积、脑容积和脑实质分数(BPF),并通过多项式曲线拟合技术,研究正常人BPF随年龄变化的函数关系。结果正常组颅腔容积为(1271322±128699)mm3,脑容积为(1211725±122077)mm3,BPF为(95.3471±2.3453)%;脑萎缩组颅腔容积为(1276900±125180)mm3,脑容积为(1203400±117760)mm3,BPF为(91.8115±2.3035)%。两组之间的颅腔容积和脑容积差异无统计学意义(P>0.05),而BPF差异具有统计学意义(P<0.001);BPF定量与年龄之间的二次多项式函数关系P(x)=-0.0008x2+0.0193x+96.9999能够较为准确表达正常人BPF随年龄变化的函数关系,其95%可信区间下限为y=-0.0008x2+0.0184x+95.1090。结论BPF与年龄之间函数关系的95%可信区间下限,可作为计算机自动定量诊断脑萎缩的客观标准。     

人型支原体感染的血清流行病学研究

1989年3～4月对南京铁咯分局1423名健康人进行了人型支原体感染的血清流行病学调查。结果表明,人群中存在Mh感染抗体阳性率为3.72％,GMT为1:3.38。感染与性别、年龄、职业、婚姻、病史以及性接触等因素有关。提示该病是一种性传播疾病,应引起高度重视。     

A method combining morphological, immunocytochemical and chromosomal examinations of the same cell in the study of lymphoproliferative diseases

6 cases of different lymphoproliferative diseases were studied with the new MAC (Morphology-Antibody-Chromosome) method in order to find out 1) if the abnormal karyotype is confined to the monoclonal cell population, 2) if there are, within this clone, also cells with a normal karyotype, and 3) if the method can help the pathologist to diagnose malignant lymphoproliferative diseases. The MAC method allows a simultaneous study in the same metaphase cell of the karyotype, surface markers, and some morphological features. In all cases in which a monoclonal cell proliferation was detected immunohistologically, the MAC examination showed a chromosomal abnormality for the same light chain as was detected in immunohistology, but not in other cells. In all but a single case, all mitotic cells belonging to the clonal cell proliferation had an abnormal karyotype. In this case with lambda clonality, 2/8 lambda-positive mitoses had a normal karyotype. However, all the normal mitoses occurred in small lymphocytes whereas the abnormal mitoses were seen in large blastic cells. In 1 case, the MAC method helped in confirming the diagnosis of malignant lymphoma (nodular small cleaved cell type). Especially in lymphomas composed of a mixed cell population, the MAC method makes it possible to find out which cell types have an abnormal karyotype and which have a normal karyotype.     

335例退行性骨关节病直流感应电康复总结

报告335例退行性骨关节病变,均经 x 线摄影证实,用直流感应电治疗。痊愈62例,占18.51%;显效115例,占34.33%;好转139例,占41.49%;无效19例;占5.67%。总有效率94.33%。有复发者再经治疗仍可收到效果。并对作用机制进行了探讨。     

2687例血清甲状腺球蛋白抗体和微粒体抗体测定及其临床意义

报告2687例血清甲状腺球蛋白抗体和甲状腺微粒体抗体的放射免疫测定结果,九类病人的抗体阳性率如下:甲状腺正常病人12.6(30/239)、孤立甲状腺结节16.9%(62/383)、弥漫性甲状腺肿35.4%(226/638)、多结节甲状腺肿54.7%(104/190)、甲亢未治疗77.7%(404/520)、甲亢治疗中67.2%(218/345)甲亢临床已治愈60.3(102/169),原发性甲减80.8%(118/146)、亚急性甲状腺炎35.1%(20/57)。各种甲状腺疾病的总阳性率为51.2%(1254/2448)。对甲状腺自抗体阳性在甲状腺疾病的诊断、治疗、和预后判断上的意义进行了讨论。     

5名电离辐射事故患者外周血T细胞T细胞抗原受体、T细胞分化抗原决定簇－3效应的研究

文中报道了５名事故性急性骨髓型放射病患者照后２．５和３．５年外周血Ｔ淋巴细胞Ｔ细胞受体（ＴＣＲ）基因，ＴＣＲ、Ｔ细胞分化抗原决定簇－３（ＣＤ_３）表达与ＴＣＲ／ＣＤ_３复合物功能的辐射效应．发现５名患者于照后２．５年，２名（５．２Ｇｙ和２．４Ｇｙ，５５岁）于照后３．５年外周血Ｔ细胞应答抗ＣＤ３单抗刺激而增殖的能力尚未完全恢复；经同时用ＩＬ－２和抗ＣＤ_３单抗刺激，增殖能力比单用抗ＣＤ_３单抗刺激有所增强；后２名的外周血ＴＣＲ、ＣＤ_３阳性细胞百分率一直低于正常对照和其他患者；并见一患者出现ＤＮＡ重排杂交带型．本文并从ＴＣＲ／ＣＤ_３在介导Ｔ细胞抗原刺激反应中的作用，电离辐射对ＴＣＲ／ＣＤ_３复合物的影响，后果和意义等方面进行了讨论．     

胆囊小隆起性病变的诊断及治疗

报告37例胆囊小隆起性病变，其中良性颈变34例，胆囊癌3例。结果：本组23例有临床症状，多表现为反复发作的右上腹疼痛或不适；病灶部位，大小，多少，有无合并胆石及病变性质与临床症状有关；B-us,OCG,CT的诊断符合率例如辚33／37，9／24和5／10（x^2=18.75,P<0.005)。认为对胆囊小隆起性病变的病灶≥10mm，有增大趋势，呈恶性图像，合并胆石或血清CEA升高的病例应及早手术治疗。     

足月新生儿颅内出血的CT诊断

经CT扫描诊断的足月新生儿颅内出血8例,就其病因、CT表现特点及CT与超声检查的比较进行讨论。提出新生儿颅内出血与孕期、胎次、分娩方式均有一定的关系,同时还应注意新生儿因脑发育不成熟在CT扫描图像上有其特殊表现。     

小儿中枢神经系统肿瘤71例病理分析

本文分析了1962年至1986年间的71例小儿中枢神经系统肿瘤的病理资料,该病占同期中枢神经系统肿瘤的16.6％。71例中,颅内肿瘤67例,椎管内肿瘤4例。颅内肿瘤中幕上38例,以星形细胞瘤多见,其次为先天性肿瘤。幕下29例以髓母细胞瘤多见,其次为星形细胞瘤。小儿中枢神经系统肿瘤以恶性居多,预后不佳。脑中线是肿瘤的好发区。