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991.
G.-M. Robertz-Vaupel K. D. Lindecken T. Edeki C. Funke S. Belwon H. J. Dengler 《European journal of clinical pharmacology》1992,42(5):465-469
Summary In the present study the effect of metastatic liver disease on hepatic drug metabolism has been examined by studying the pharmacokinetics of antipyrine and the urinary excretion of antipyrine and its three major metabolites (4-hydroxyantipyrine, norantipyrine, and 3-hydroxymethylantipyrine) in 12 patients with extensive metastatic liver disease, and in 12 matched healthy controls.In the patients total liver volume, the volume of the liver parenchyma, and the volume of the liver metastases were determined by computed tomography. The volume of liver metastases always exceeded 35% of the total liver volume.There were no significant differences between the patients and controls in plasma half-life, plasma clearance, or apparent volume of distribution of antipyrine.The cumulative urinary excretion of antipyrine and its three major metabolites was significantly lower in patients [44 (18)%] than in controls [71 (8)%]. The excretion of antipyrine itself was unchanged and the decrease in cumulative excretion was due to reduced excretion of the three metabolites.The results show that the activity of the hepatic mixed function oxidases was not impaired even in patients with extensive metastatic liver disease. This may be because liver metastases do not cause a corresponding reduction in the volume of normal hepatic parenchyma. The decreased urinary excretion of the three major metabolites of antipyrine, which are mainly glucuronidated, may have been due to an alteration in the process of conjugation. 相似文献
992.
采用放射免疫法测定实验性胆道炎症兔胆系组织以及几种胆道疾患病人胆系组织中6-keto-PGF1α与TXB2的含量。结果显示:动物模型组与病人组的上述两指标均显著增高;AOSC病人的TXB2增高更明显,而胆道梗阻病人胆管组织无此变化。提示前列腺素类及血栓素对胆道炎症的发生可能有关,TXB2的负性作用尤为重要。 相似文献
993.
994.
对阳城县3646名15岁以上人群吸烟状况分析表明,男性吸烟率63.71%,女性吸烟率0.64%,男女合计吸烟率31.49%,并对不同年龄、职业、文化程度与吸烟率的关系进行了分析。吸烟心理动机:“烟草成瘾”占32.06%,“消遣”占28.48%,“解除疲劳”占16.90%,“交际”占22.56%。吸烟人群的4周患病率和慢性病患病率均高于不吸烟人群,两组差别有显著性(P<0.05,P<0.001)。 相似文献
995.
996.
Th. Büttner S. Schulz W. Kuhn A. Blumenschein H. Przuntek 《European journal of neurology》1994,1(2):153-157
Colour discrimination and visual contrast perception were investigated in 18 patients with Huntington's disease (HD) and in 18 age- and sex-matched healthy volunteers using the Farnsworth-Munsell 100 Hue test (FM) and stationary contrast targets. The mean total error score (MTES) and the partial scores for the “red-green” and the “blue-yellow” axes in the FM of the patients with HD were significantly elevated as compared to controls (MTES in HD: 113.0 ± 90.8; MTES in controls: 19.2 ± 8.8). The spatial contrast sensitivity in HD patients was normal. The colour perception dysfunction indicates that the visual system is affected in HD. The visual disorder may be related to an imbalance of certain neurotransmitters in the visual system of HD patients. Possible anatomical sites of the dysfunction responsible for colour discrimination abnormalities could be the retinal cone system and/or impaired parvocellular central visual pathways in HD. 相似文献
997.
998.
本文对肺部三种疾病1536例患者的病历资料,按病种作了统计归类。运用模糊数学原理建立了征候一疾病间的模糊关系矩阵,用参量加权模糊综合评判模型,对肺部三种疾病鉴别诊断的符合率达82.91%以上,因此认为文中建立的模型,对肺部三种疾病鉴别诊断具有参考价值。 相似文献
999.
I. Aiello G. F. San R. Cacciotto M. V. Puliga M. E. Lentinu S. Muzzu D. Posadinu S. Traccis 《Journal of neurology》1992,239(2):65-68
Summary In Wilson's disease neurological manifestations result from the damage in the basal ganglia, even if a widespread degeneration of the brain occurs. The few studies performed using evoked potentials with the aim of identifying subclinical dysfunction in the three major sensory pathways have never shown abnormalities in patients without neurological manifestations. To verify this observation we studied 12 patients suffering from Wilson's disease in a pre-neurological stage by using pattern visual evoked potentials (VEPs), somatosensory evoked potentials (SEPs) to median nerve stimulation and brainstem auditory evoked potentials (BAEPs). Four of these patients had not yet been treated with penicillamine or trientine (triethylenetetramine dihydrochloride), while the remaining 8 patients were on treatment for at least 1 year. In 3 patients of this second group and in 1 patient of the first group we observed a significant (3 SD over the mean) increase in P100 wave latency, while SEPs and BAEPs were found to be abnormal in only 1 patient, respectively. 相似文献
1000.
性传播疾病危险人群乙型肝炎和丙型肝炎病毒感染的血清流行病学调查 总被引:1,自引:0,他引:1
通过对431名卖淫妇女和109名正常妇女HBV和HCV感染的血清学指标的检测、性传播有关因素的调查,发现卖淫妇女HBV和HCV感染中的抗-Hkc为43.15%,抗-HBs为36.89%,HBsAg为10.44%,抗-HCV为9.51%,明显高于正常妇女;有性传播疾病者HBV和HCV的各项感染指标也明显高于正常妇女。卖淫妇女的抗-HCV感染率有随年龄增长而增高的趋势,与卖淫时限长、卖淫次数多有明显差别,这表明卖淫妇女中有较严重的HBV和HCV感染。 相似文献