粘蛋白在胆囊腺瘤样息肉中的表达及意义

目的　研究 4种粘蛋白在胆囊腺瘤样息肉中的表达规律并探讨其意义。方法　采用粘蛋白 1(Mucin1,MUC1)、粘蛋白 2(MUC2 )、粘蛋白 3 (MUC3 )及粘蛋白 5AC(MUC5AC)的单克隆抗体 ,应用免疫组化和Westernblot检测对照组胆囊 2 4例 ,胆囊腺瘤样息肉19例。结果　MUC1、MUC2及MUC5AC免疫组化及Westernblot表达在胆囊腺瘤样息肉组较对照组显著增高 (P <0 .0 1) ,而MUC3在腺瘤样息肉组较对照组显著降低 (P <0 .0 1)。结论　粘蛋白在胆囊腺瘤样息肉中呈现非同步表达 ,可能与其属癌前病变有关。     

Nasal intubation: A minimally obtrusive anosmia technique applied to rats

Nasal intubation represents a reversible, nonsurgical anosmia technique which produces little behavioral or physiological disruption. A polyethylene tube of sufficient length to extend from the narial opening past the various olfactory receptors is inserted into each nasal cavity. Thus, the animal can breathe freely through the tube, but the length of the tube prevents air from contacting olfactory receptors. To reverse the technique, the tubes are simply pulled out. The intubation technique was examined for the ability to produce anosmia with minimal nonolfactory behavioral disruption. Intubated animals lost the ability to perform olfactory discrimination, but completely regained olfactory discrimination ability once the tubes were removed. Controls for the effects of intubation on discriminative responding showed no deficit. Olfactory detection tests revealed intubated animals lost the ability to locate buried, scented food. Controls for the effects of intubation showed no deficit in olfactory detection. Open field tests, daily weight records, and subjective judgments of ease of handling, used to assess the secondary effects of intubation, showed no significant effect of intubation.     

Radiotherapy for inverted papilloma: a case report

Inverted papilloma is an infrequent tumour of the nasal cavity and paranasal sinuses associated with controversy. The incidence of carcinoma in situ associated with inverted papilloma, has not been very well documented until now. Therefore, we present a case report characterized by an aggressive clinical behaviour, treated by extensive surgery and ultimately controlled by radiotherapy.     

鼻息肉起源部位的观察分析

目的：观察鼻息肉的起源部位，以探讨鼻息肉病因。方法：应用电动吸切器切除６９例（１１２侧）鼻息肉的同时进行内镜检查，对窦口鼻道复合体的解剖结构进行观察。结果：１１２侧鼻息肉中起源于筛泡气房的１５侧、鼻丘气房１１例、钩突１５侧、中鼻气房１１侧、中鼻甲息肉样变１９侧、上颌窦口７侧、额隐窝５侧、筛漏斗５侧、多源者２４侧。结论：鼻息肉的发生与窦口鼻道复合体的解剖畸形及炎症有密切关系。     

Salmon-calcitonin nasal spray in Paget's disease of bone: Preliminary results in five patients

Summary The effectiveness of Synthetic Salmon Calcitonin (SSCT) administered as a nasal spray was assessed via clinical, biological, and radiological variables in 5 Pagetic patients during a 6 months course therapy, the results show that intranasal administration does not decrease the activity of SSCT in Paget's disease of bone.     

鼻腔肿物的X线诊断（附40例分析）

本文分析经证实的４０例鼻腔肿物，其中良性３０例，恶性１０例。４０例中误诊６例，含良、恶性间错诊５例和继发性癌肿误为原发恶性肿瘤１例。作者分析讨论了误诊原因如下：（１）Ｘ线检查方法选择不当；（２）对鼻腔良性肿物的不常见Ｘ线表现认识不足；（３）综合临床资料进行全面分析不够。最后，提出在以上三个方面诊断的注意点。     

Peutz-Jeghers syndrome with pseudoinvasion of hamartomatous polyps and multiple epithelial neoplasms

The risk of malignant change developing in the hamartomatous polyps in Peutz-Jeghers syndrome is widely held to be negligible. However an association with tumours of the upper gastro-intestinal tract, ovary and other diverse multiple neoplasms is now recognized. Previously reported cases of malignant change in Peutz--Jeghers polyps may represent 'pseudoinvasion' and we report such a case. This was associated with carcinomas of the bile ducts, left tonsil and a papillary adenoma of the pancreatic duct. It lends further support to the view that there may be a genetic predisposition to the development of neoplasms in this condition. Pathologists and clinicians must be aware of this entity of 'pseudoinvasion' in order to avoid unnecessarily radical surgery in Peutz-Jeghers syndrome.     

鼻中隔穿孔手术治疗41例报告

目的 :探讨手术治疗鼻中隔穿孔的最佳径路和方法。方法 :鼻中隔穿孔 4 1例中 ,经前鼻孔径路 10例 ,经鼻翼切开径路 16例 (联合内镜 1例 ) ,蝶形切开径路 6例 ,鼻内镜下径路 8例 ,唇下径路 1例 ,手术均在局麻下进行 ,31例用复合瓣修补 ,用耳脑胶固定。结果 :经前鼻孔径路单层瓣膜修补 10例中 ,4例再穿孔 ,采用鼻翼切开 ,鼻翼鼻小柱蝶形切开 ,鼻内镜下径路 ,复合瓣修补 ,耳脑胶固定治疗 ,均一期愈合。结论 :对不同的鼻中隔穿孔要用不同的手术径路 ,复合瓣修补 ,耳脑胶固定瓣膜等是目前修补鼻中隔穿孔的有效方法     

CO2激光与纤维喉镜治疗声带息肉的疗效对比

目的:比较CO2 激光与纤维喉镜治疗声带息肉的疗效,以及两种方法的最佳适应征。方法:80例声带息肉患者分为两组,分别用CO2 激光与纤维喉镜治疗,治疗2月后,以声带运动、边缘光滑、发音质量为指标进行评价。结果:CO2 激光与纤维喉镜总有效率分别为93%、75 % ,两者差异无显著性(P >0 .0 5 ) ,但两组对广基息肉的治愈率分别为92 %、6 4% ,差异有显著性(P <0 .0 5 )。结论:两种方法总有效率相似,但治疗广基息肉,CO2 激光治疗要优于纤维喉镜。