高频热疗机配合针灸治疗慢性前列腺炎肾阳虚证的临床研究

目的运用高频热疗机配合针灸治疗慢性前列腺炎肾阳虚证的疗效观察.方法 治疗组:针灸取穴:肾俞、膀胱俞、三阴交、中级、归来、足三里、关元,配合高频热疗机治疗,观察4周.对照组:口服盐酸左氧氟沙星胶囊,一次0.2g,一日两次,观察4周.结果 经治疗后治疗组的临床疗效和中医证候疗效明显优于对照组的临床疗效和中医证候疗效(p<0.05).结论 慢性前列腺炎肾阳虚证的治疗适合应用针灸联合高频热疗机,并且疗效可靠,尚未发现不良反应.     

Longitudinal Nutritional Intakes in Italian Pregnant Women in Comparison with National Nutritional Guidelines

Background: Nutritional quality during pregnancy is crucial for mother and child health and their short/long-term outcomes. The aim of this study is to evaluate the adherence to nutritional recommendations in Italy during the three pregnancy trimesters in Normal Weight (NW) and Over Weight (OW) women. Methods: Data from a multicenter randomized controlled trial included 176 women (NW = 133; OW = 43) with healthy singleton pregnancies enrolled within 13 + 6 weeks of gestation. Dietary intake was assessed every trimester by a Food Frequency Questionnaire. Results: OW and NW had similar gestational weight gain. However, as Institute of Medicine (IOM) recommend lower gestational weight gain (GWG) for OW, they exceeded the suggested range. In both groups, caloric intake during the three trimesters never met recommendations. Protein intake in first and second trimester was higher than recommendations, as was sugars percentage. Dietary fiber intake was lower in OW. Polyunsaturated fatty acids, calcium, iron and folic acid requirements were never satisfied, while sodium intake exceeded recommendations. Conclusions: NW and OW women in Italy do not adhere to nutritional recommendations during pregnancy, with lower caloric intake, protein and sugars excess and inadequacies in micronutrients intake. Pregnant women in Italy should be provided with an adequate counseling and educational intervention as well as supplementation when indicated.     

高频彩超对小体积恶性乳腺叶状肿瘤的诊断价值

目的探讨高频彩超对小体积恶性乳腺叶状肿瘤的诊断价值,提高小体积恶性PTB的术前诊断率。方法回顾分析4例经手术病理确诊的小体积恶性乳腺叶状肿瘤的声像图表现,并与该研究在同一台机器同一探头操作、预设条件一样前提下,病灶大小接近的,患者年龄相仿的,病灶深度差不多的6例纤维腺瘤的声像图进行对比分析。结果肿块最小者2.1cm×1.8 cm,最大者4.6 cm×3.7 cm;小体积恶性乳腺叶状肿瘤的CDFI表现：血供较丰富,Ⅱ级1例,Ⅲ级3例。纤维腺瘤的CDFI表现：血供较稀疏,0级1例,Ⅰ级4例,Ⅱ级1例。结论小体积恶性乳腺叶状肿瘤的CDFI表现具有较高的特异性,容易分辨,对于诊断小体积恶性乳腺叶状肿瘤有较高的实用价值。     

共振频率分析评价微型种植体支抗稳定性

目的运用共振频率分析仪评价微型种植体支抗的稳定性,为微型种植体早期加载提供理论依据。方法成年Beagle犬3只,分别在犬下颌两侧牙槽骨内各植入微型种植体支抗5枚。随机分为2组,实验组2周后加载100 g的水平力,加载时间为12周;对照组不加载。分别于微型种植体支抗植入后即刻、术后6周、术后10周、术后14周使用共振频率分析仪(Osstell Mento)测定2组微型种植体的稳定性,所得参数为微型种植体稳定值(ISQ)。采用SPSS17.0软件对数据进行分析。结果术后14周,2组微型种植体的成功率均为100%,2组微型种植体在各时间段的ISQ值无显著性差异(P>0.05),整体变化趋势表现为稳定性逐渐升高,于术后6周达到最大,其后逐渐减小,术后10周基本稳定,术后14周略有增加。结论 2周后负载不影响微型种植体支抗的稳定性。     

Frequency of consumption of foods and beverages by Inuvialuit adults in Northwest Territories,Arctic Canada

Limited data exist regarding nutrient intakes and overall dietary quality in Canadian Arctic populations. This cross-sectional study determined the frequency of consumption of traditional meats (e.g. caribou, polar bear, seal, char and whale) and non-traditional store-bought foods including non-traditional meats (e.g. beef, pork and chicken), grains, dairy, fruits, vegetables and non-nutrient dense foods (NNDFs) (e.g. butter, chocolate, chips, candy and pop) by Inuvialuit adults (175 women, mean age 44 ± 14 years; 55 men, mean age 41 ± 13 years) in three remote communities in the Northwest Territories. Using a validated quantitative food frequency questionnaire, frequency of consumption over a 30-day period was determined for 141 commonly reported foods. Mean consumption of traditional meats (1.6 times/day), fruits (1 time/day) and vegetables (0.6 times/day) was less frequent than that of NNDFs (5.0 times/day). Nutritional intervention strategies are needed to promote more frequent consumption of nutrient-rich foods and less frequent consumption of NNDFs in these Arctic communities.     

Novel Mutations Responsible for α-Thalassemia in Iranian Families

α-Thalassemia (α-thal) is usually caused by deletions on the α-globin gene cluster and the role of point mutations is less well investigated. In the present study, a total of 1048 individuals with hypochromic microcytic anemia, who did not present the most common α-thal deletions, were referred for α-globin gene DNA sequencing. The nucleotide changes were studied and a total of five new mutations was identified, of which three were located on the α2 gene [codon7 (Lys→Stop), codon 34 (Leu→Pro) and codon 83 (Leu→Arg)] and two on the α1 gene [IVS-I-116 (A>G) and codon 44 (+C)]. These novel mutations not only explain new findings by molecular analysis of the α-globin gene but also have clinical importance due to their changes in α-globin production in means of decreased hemoglobin (Hb) related values. Moreover, considerations of its role in combination with other mutations, and the possibility of causing Hb H (β4) are yet to be studied.     

Community Dwelling Elderly Are Appropriate Subjects for Intensive Dietary Choice Restriction Studies

There is a traditional belief that the elderly have difficulty coping with dietary change, and therefore have a diminished likelihood of successfully responding to nutritional interventions or restrictions. Using a controlled mild zinc-deficiency feeding study as a model for strict dietary intervention, we assessed psychological responses to severe dietary choice restriction in 15 Caucasian, elderly (66.12 ± 4.43 years) males (n = 7) and females (n = 8). Participants completed the Medical Outcomes Study Short Form 36-Item Questionnaire (SF-36) as an index of QOL and the Multi-dimensional Health Locus of Control (MHLC) as a measure of health beliefs at pre-intervention baseline, post-intervention, and follow-up. No subjects dropped out nor were any meals missed during the entire 21-day feeding study period. No significant differences were detected across time on the MHLC (Internal F = 0.53, P = 0.6; Powerful Others F = 0.28, P = 0.8; Chance F = 1.1, P = 0.4.) by one-way ANOVA. Similarly, for the SF-36 no significant differences were found across time (F = 0.76, P = 0.5). Our results suggest that restricting dietary choices does not negatively impact older adult subjects and that they can cope well with dietary choice restriction and change. Older adults should not be overlooked for nutritional intervention solely due to age considerations.     

2002 North American Congress of Clinical Toxicology Annual Meeting - Platform Session III,Clinical Toxicology and Basic Science,Abstracts 63–67

This special issue of Clinical Toxicology contains abstracts from the 2002 North American Congress of Clincal Toxicology Anual Meeting held September 24 - 29, 20002 in Palm Springs California. The abstracts have been grouped for online delivery based on the date and type of presentation as shown in the Program Outline for the conference. The Program Outline, Subject Index and Author Index for the meeting has been included at the end of each grouping for reference purposes.     

Design and characterization of a dynamic vibrational culture system

To engineer a functional vocal fold tissue, the mechanical environment of the native tissue needs to be emulated in vitro. We have created a dynamic culture system capable of generating vibratory stimulations at human phonation frequencies. The novel device is composed of a function generator, a power amplifier, an enclosed loudspeaker and a circumferentially‐anchored silicone membrane. The vibration signals are translated to the membrane aerodynamically by the oscillating air pressure underneath. The vibration profiles detected on the membrane were symmetrical relative to the centre of the membrane as well as the resting position over the range of frequencies (60–300 Hz) and amplitudes tested (1–30 µm). The oscillatory motion of the membrane gave rise to two orthogonal, in‐plane strain components that are similar in magnitude (0.47%) and are strong functions of membrane thickness. Neonatal foreskin fibroblasts (NFFs) attached to the membrane were subjected to a 1 h vibration at 60, 110 and 300 Hz, with the displacement at the centre of the membrane varying in the range 1–30 µm, followed by a 6 h rest. These regimens did not cause morphological changes to the cells. An increase in cell proliferation was detected when NFFs were driven into oscillation at 110 Hz with a normal displacement of 30 µm. qPCR results showed that the expression of genes encoding some extracellular matrix proteins was altered in response to changes in vibratory frequency and amplitude. The dynamic culture device provides a potentially useful in vitro platform for evaluating cellular responses to vibration. Copyright © 2011 John Wiley & Sons, Ltd.     

超声引导肝恶性肿瘤射频消融术与手术切除对细胞免疫影响的对比研究

目的探讨超声引导下射频消融术与手术切除术对肝癌患者外周血T淋巴细胞亚群的影响。方法应用流式细胞仪检测,30例以射频消融为治疗方式和30例以手术切除为治疗方式的原发性肝癌患者的术前、术后T淋巴细胞亚群的变化。结果射频组术后10d和20d外周血中CD3+、CD4+、CD4+/CD8+水平均明显高于术前水平,CD8+明显低于术前,差异均有统计学意义(均P0.05),且持续时间较长。手术组外周血中CD3+、CD4+、CD4+/CD8+水平明显低于术前水平,CD8+明显高于术前,差异均有统计学意义(P0.05)。射频组术后10 d和20 d外周血中CD3+、CD4+、CD4+/CD8+均明显高于手术组,CD8+明显低于手术组,差异均有统计学意义(均P0.05)。结论射频消融治疗肝癌患者细胞免疫功能增强,手术治疗则免疫细胞功能下降。射频消融在保护与改善细胞免疫功能方面强于手术治疗方法。