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71.
Greg T. Gdowski Timothy Belton Robert A. McCrea 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2001,140(3):253-264
Passive rotation of the trunk with respect to the head evoked cervico-ocular reflex (COR) eye movements in squirrel monkeys. The amplitude of the reflex varied both within and between animals, but the eye movements were always in the same direction as trunk rotation. In the dark, the COR typically had a gain of 0.3–0.4. When animals fixated earth-stationary targets during low-frequency passive neck rotation or actively tracked moving visual targets with head movements, the COR was suppressed. The COR and vestibulo-ocular reflex (VOR) summed during passive head-on-trunk rotation producing compensatory eye movements whose gain was greater than 1.0. The firing behavior of VOR-related vestibular neurons and cerebellar flocculus Purkinje cells was studied during the COR. Passive neck rotation produced changes in firing rate related to neck position and/or neck velocity in both position-vestibular-pause neurons and eye-head-vestibular neurons, although the latter neurons were much more sensitive to the COR than the former. The neck rotation signals were reduced or reversed in direction when the COR was suppressed. Flocculus Purkinje cells were relatively insensitive to COR eye movements. However, when the COR was suppressed, their firing rate was modulated by neck rotation. These neck rotation signals summed with ocular pursuit signals when the head was used to pursue targets. We suggest that the neural substrate that produces the COR includes central VOR pathways, and that the flocculus plays an important role in suppressing the reflex when it would cause relative movement of a visual target on the retina. Electronic Publication 相似文献
72.
Ping-Bo Yin Shigeru Kitazawa 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2001,141(2):250-253
The errors in target-reaching that are produced by laterally displacing vision with wedge prisms decrease with trials (prism adaptation). When the prisms are removed, errors in the opposite direction are observed (aftereffect). We investigated the size of the aftereffect 24 h and 72 h after a monkey had adapted to a visual displacement (30 mm), with rapid reaching movements. The aftereffect more than half of the size of the displacement was observed when the effect was tested immediately after the monkey had been exposed to the displacement for 50 trials. In contrast, the aftereffect was not observed at 24 h even when the monkey had been exposed to the displacement for 250 trials. However, when the monkey had been exposed for 500 trials, significant aftereffects more than half of the size of the displacement were observed at 24 h and 72 h. When both arms were adapted to opposite prism displacements, the long-lasting aftereffect was further shown to be specific for the arm used during the exposure. The results indicate that the aftereffects of prism adaptation last for at least 3 days, though more than 200 trials of additional repetition are required to consolidate the short-term effects into long-lasting ones. 相似文献
73.
The perirhinal cortex is known to support high-level perceptual abilities as well as familiarity judgments that may affect recognition memory. We tested whether poor perceptual abilities or a loss of familiarity judgment contributed to the recognition memory impairments reported earlier in monkeys with PRh lesions received in infancy (Neo-PRh) (Weiss and Bachevalier, 2016; Zeamer et al., 2015). Perceptual abilities were assessed using a version of the Visual Paired Comparison task with black&white (B&W) stimuli, and familiarity judgments were assessed using the Constant Negative task requiring repeated familiarization exposures. Adult monkeys with Neo-PRh lesions were able to recognize B&W stimuli after short delays, suggesting that their perceptual abilities were within the range of control animals. However, the same Neo-PRh monkeys were slower to acquire the Constant Negative task, requiring more exposures to objects before judging them as familiar compared to control animals. Taken together, the data help to account for the differential patterns of functional compensation on previously reported recognition tasks following neonatal versus adult-onset PRh lesions, and provide further support to the view that the PRh is involved in familiarity processes. 相似文献
74.
Distinguishing potentially harmful or beneficial stimuli is necessary for the self-preservation and well-being of all organisms. This assessment requires the ongoing valuation of environmental stimuli. Despite much work on the processing of aversive- and appetitive-related brain signals, it is not clear to what degree these two processes interact across the brain. To help clarify this issue, this report used a cross-species comparative approach in humans (i.e. meta-analysis of imaging data) and other mammals (i.e. targeted review of functional neuroanatomy in rodents and non-human primates). Human meta-analysis results suggest network components that appear selective for appetitive (e.g. ventromedial prefrontal cortex, ventral tegmental area) or aversive (e.g. cingulate/supplementary motor cortex, periaqueductal grey) processing, or that reflect overlapping (e.g. anterior insula, amygdala) or asymmetrical, i.e. apparently lateralized, activity (e.g. orbitofrontal cortex, ventral striatum). However, a closer look at the known value-related mechanisms from the animal literature suggests that all of these macroanatomical regions are involved in the processing of both appetitive and aversive stimuli. Differential spatiotemporal network dynamics may help explain similarities and differences in appetitive- and aversion-related activity. 相似文献
75.
《The International journal of neuroscience》2012,122(7):855-868
The aim of this article was to describe an apparatus, called multipurpose neck robot (MUPRO), designed to record both the forces exerted at head level and the head rotations in the horizontal plane in the behaving monkey. It consists of a mechanical device, comprising a cardan joint, a potentiometer, an electromagnetic brake, and four flexion load cells, plus an oleodynamic system allowing head rotation in the horizontal plane between - 20° These components are assembled on a column bolted to the primate s chair. An electrical device provides DC power for the potentiometer and the brake. The apparatus enables us to measure both the force fields and the head movements during training sessions and electrophysiological investigations. 相似文献
76.
Brain endothelial cells (BECs), specialized cells of the blood–brain barrier (BBB), are ideally positioned to monitor and respond to events in the periphery. The present study examined their potential role in transducing immune signals to the brain and in responding to noxious stimuli. BECs were isolated from rhesus monkeys at 3 age points (fetal/neonatal, adult, and very old animals). Cells were then challenged in vitro with either an immune stimulus (interleukin-1β (IL-1β), or lipopolysaccharide (LPS)) or an oxidative challenge (hypoxia). BECs released interleukin-6 (IL-6), which is known to have neurotrophic and neuroprotective functions. Furthermore, higher amounts of IL-6 were released in both baseline and stimulated conditions by BECs derived from aged animals. This research indicates a pathway whereby immune signals may be communicated to the CNS and has revealed one way that the BBB may protect neuronal survival under challenge conditions. 相似文献
77.
Matsuya T Takamatsu H Murakami Y Noda A Ichise R Awaga Y Nishimura S 《Nuclear medicine and biology》2005,32(8):837-844
This report describes the synthesis of [11C]2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone ([11C]FR194921), a highly selective, nonxanthine-type adenosine A1 receptor antagonist, used in brain imaging in rats and conscious monkeys as a potential novel PET tracer. [11C]FR194921 was successfully synthesized in 19 min after [11C]CH3I formation. The radiochemical yield was 38±3%; and radioactivity was 4.1±0.4 GBq, calculated from end of synthesis; radiochemical purity was higher than 99%; and the specific radioactivity was 25.0±8.1 GBq μmol−1 (n=5). In a rat experiment, the distribution of [11C]FR194921 was higher in the hippocampus, striatum and cerebellum regions. This accumulation was significantly decreased by approximately 50% by pretreatment with 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), an adenosine A1 receptor antagonist, which indicated specific binding of the radioligand to adenosine A1 receptors. In conscious monkey PET experiments, [11C]FR194921 accumulated in several regions of the brain, especially in the occipital cortex, thalamus and striatum. These results suggest that [11C]FR194921 can be used as an agent for imaging adenosine A1 receptors in vivo by positron emission tomography (PET). 相似文献
78.
Leopoldo Bon Cristina Lucchetti 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,113(1):180-185
This study investigated whether the neuronal activity of a cortical area involved in the control of eye fixation is affected
by the covert orienting of attention. We recorded single-unit activity from the supplementary eye field (SEF) of two macaque
monkeys performing fixation and peripheral-attention tasks. Ninety-nine out of four hundred and fifteen cells were related
to eye movements. The other neurons showed relationship with postural adjustments, and arm and ear movements. Fifty-five neurons
were active during fixation (fixation cells) and 44 discharged in relation to saccades. The experiments reported here primarily
concern the fixation cells. The activity of 64% (35/55) of fixation cells started with the onset of visual stimulus, before
the visual input reached the fovea, and continued during active fixation. The activity of 27% (15/55) of fixation cells started
with the onset of fixation. The activity of 9% (5/55) of fixation cells modified their timing trial by trial. Sixty-four percent
of the fixation cells (35/55) were position-dependent, showing a selective spatial field of activity, 36% (20/55) were position-independent
and characterized by a full spatial field. None of the 55 cells showed a visual receptive field. We tested both types of fixation
cells by means of a peripheral attention task. When attention was oriented peripherally toward a target located in the selective
spatial field, the cells discharged as if the gaze was held toward it. When attention was oriented peripherally toward a target,
lying outside the selective spatial field, the cells were inactive as if gaze was held in that position. These results suggest
that the supplementary eye field neurons may code for oriented attention in space and might be involved in the preparation
of motor action.
Preliminary results were presented at the 1994 ENA meeting in abstract form 相似文献
79.
Jan Kucera 《Anatomy and embryology》1985,173(1):95-104
Summary The nerve supply to 25 poles of muscle spindles in the monkey was reconstructed by light microscopy of serial 1-m thick transverse sections of lumbrical muscles. Twenty of 60 motor axons that supplied the spindle poles were identified as skeletofusimotor (). Twenty-eight percent of the spindle poles were innervated by axons, in addition to axons. Every -innervated spindle pole transected an endplate zone of extrafusal muscle. Most axons coinnervated extrafusal fibers rich in mitochondria and the nuclear bag1 or nuclear chain intrafusal fibers. All but two axons innervated one type of intrafusal fiber only. The intramuscular organization of motor system in lumbrical muscles of the monkey was similar to that of the cat tenuissimus muscle. The function of -innervated spindles may be preferentially to monitor mechanical disturbances arising from the activity of extrafusal muscle units with which they share motor innervation. 相似文献
80.
R. Wiesendanger M. Wiesendanger 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1985,59(1):105-117
Summary 1. The possibility of a cerebellar linkage, via the thalamus with medial area 6 of the cerebral cortex was further explored in the present experiments (cf. preceding companion paper). 2. It was found that HRP conjugated to the lectin wheat germ agglutinin injected into motor cortical areas was transported beyond the thalamus to the contralateral intracerebellar nuclei when the survival time was 4–7 days. 3. It is suggested that the labeling in the deep cerebellar nuclei occurred via the thalamic relay where cerebellofugal fibre terminals had taken up the marker substance released by corticothalamic fibre terminals or by the retrogradely labeled thalamic perikarya. 4. In general, transcellular labeling of perikarya was weaker than retrograde labeling in the thalamic cells. Some of the nuclear zones in the cerebellum showed relatively dense granulations of the reaction product; in other zones only cells with few granules were seen, and large parts of the nuclei were not labeled at all. 5. The topography of secondary labeling in the cerebellar nuclei depended on the cortical injection sites. In all cases, most labeling was found in the contralateral dentate nucleus. The interposed nucleus received a fair amount of heavy labeling only in the precentral arm and face cases. Very little labeling was seen in the fastigial nucleus and in the cerebellar nuclei ipsilateral to the cortical injections. A somatotopic organization of secondary labeling was noted in the precentral cases with the face being represented caudally, the hindlimb rostrally and the arm between the face and the hindlimb representation. This is in agreement with previous anatomical and electrophysiological investigations. 6. These observations thus lend support to the conclusion that the SMA receives a transthalamic input not only from the basal ganglia but also from the cerebellum, especially from its lateral, neocerebellar portion.Abbreviations AI
Nucleus interpositus anterior
- CM
Nucleus centrum medianum
- CSL
Nucleus centralis lateralis superior
- D
Nucleus dentatus
- F
Nucleus fastigius
- I
Nucleus interpositus
- MD
Nucleus medialis dorsalis
- NRTP
Nucleus reticularis tegmenti pontis
- PI
Nucleus interpositus posterior
- PN
Griseum pontis
- SMA
Supplementary motor cortex
- STh
Nucleus subthalamicus
- VLc
Nucleus ventralis lateralis, pars caudalis
- VLo
Nucleus ventralis lateralis, pars oralis
- VPLo
Nucleus ventralis posterior lateralis, pars oralis
- X
Nucleus X 相似文献