全文获取类型
收费全文 | 66829篇 |
免费 | 4379篇 |
国内免费 | 1890篇 |
专业分类
耳鼻咽喉 | 430篇 |
儿科学 | 948篇 |
妇产科学 | 590篇 |
基础医学 | 7599篇 |
口腔科学 | 1095篇 |
临床医学 | 6192篇 |
内科学 | 6763篇 |
皮肤病学 | 371篇 |
神经病学 | 8836篇 |
特种医学 | 2090篇 |
外国民族医学 | 2篇 |
外科学 | 4574篇 |
综合类 | 10722篇 |
现状与发展 | 6篇 |
预防医学 | 9992篇 |
眼科学 | 702篇 |
药学 | 7549篇 |
97篇 | |
中国医学 | 2442篇 |
肿瘤学 | 2098篇 |
出版年
2024年 | 221篇 |
2023年 | 1044篇 |
2022年 | 1892篇 |
2021年 | 2605篇 |
2020年 | 2456篇 |
2019年 | 1860篇 |
2018年 | 1830篇 |
2017年 | 1843篇 |
2016年 | 2070篇 |
2015年 | 2063篇 |
2014年 | 4239篇 |
2013年 | 4611篇 |
2012年 | 4109篇 |
2011年 | 4474篇 |
2010年 | 3527篇 |
2009年 | 3383篇 |
2008年 | 3470篇 |
2007年 | 3283篇 |
2006年 | 2964篇 |
2005年 | 2517篇 |
2004年 | 2112篇 |
2003年 | 1852篇 |
2002年 | 1476篇 |
2001年 | 1271篇 |
2000年 | 1072篇 |
1999年 | 902篇 |
1998年 | 893篇 |
1997年 | 871篇 |
1996年 | 722篇 |
1995年 | 686篇 |
1994年 | 672篇 |
1993年 | 575篇 |
1992年 | 544篇 |
1991年 | 527篇 |
1990年 | 436篇 |
1989年 | 386篇 |
1988年 | 401篇 |
1987年 | 376篇 |
1986年 | 346篇 |
1985年 | 468篇 |
1984年 | 399篇 |
1983年 | 244篇 |
1982年 | 265篇 |
1981年 | 243篇 |
1980年 | 227篇 |
1979年 | 145篇 |
1978年 | 135篇 |
1977年 | 120篇 |
1976年 | 87篇 |
1974年 | 45篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
Physiologic assessment of diseases of the motor unit from the anterior horn cells to the muscles relies on a combination of needle electromyography (EMG) and nerve conduction studies (NCS). Both require a unique combination of knowledge of peripheral nervous system anatomy, physiology, pathophysiology, diseases, techniques, and electricity is necessary. Successful, high‐quality, reproducible EMG depends on the skills of a clinician in patient interaction during the physical insertion and movement of the needle while recording the electrical signals. These must be combined with the skill of analyzing electric signals recorded from muscle by auditory pattern recognition and semiquantitation. 10 , 52 This monograph reviews the techniques of needle EMG and waveform analysis and describes the types of EMG waveforms recorded during needle EMG. © 2009 Wiley Periodicals, Inc. Muscle Nerve 39: 244–270, 2009 相似文献
63.
Parastoo Jangouk Thomas Dehmel Gerd Meyer Zu Hörste Andreas Ludwig Helmar C. Lehmann Bernd C. Kieseier 《Glia》2009,57(16):1765-1774
The disintegrin and metalloproteinase 10 (ADAM10) is a membrane‐anchored metalloproteinase with both proteolytic and disintegrin characteristics. Here, we investigate the expression, regulation, and functional role of ADAM10 in axonal outgrowth and myelination of the peripheral nerve. Expression pattern analysis of 11 ADAM family members in co‐cultures of rat dorsal root ganglia (DRG) neurons and Schwann cells (SCs) demonstrated the most pronounced mRNA expression for ADAM10. In further studies, ADAM10 was found to be consistently upregulated in DRG‐SC co‐cultures before the induction of myelination. Neurons as well as SCs widely expressed ADAM10 at the protein level. In neurons, the expression of ADAM10 was exclusively limited to the axons before the induction of myelination. Inhibition of ADAM10 activity by the hydroxamate‐based inhibitors GI254023X and GW280264X resulted in a significant decrease in the mean axonal length. These data suggest that ADAM10 represents a prerequisite for myelination, although its activity is not required during the process of myelination itself as demonstrated by expression analysis of myelin protein zero (P0) and Sudan black staining. Hence, during the process of myelin formation, ADAM10 is highly upregulated and appears to be critically involved in axonal outgrowth that is a requirement for myelination in the peripheral nerve. © 2009 Wiley‐Liss, Inc. 相似文献
64.
Fu-Wei Wang Yu-Wen Chiu Ming-Shium Tu Ming-Yueh Chou Chao-Ling Wang Hung-Yi Chuang 《International archives of occupational and environmental health》2009,82(7):819-825
Purpose There has been increasing interest in the occupational health of workers in small enterprises, especially in developing countries.
This study examines the association between psychosocial job characteristics and fatigue, and attempts to identify risk factors
for fatigue among workers of small enterprises in southern Taiwan.
Methods A structured questionnaire was administered to workers receiving regular health examinations between August 2005 and January
2006. The questionnaire collected demographic information and data on working conditions, personal health status and life
styles. It also collected information on psychosocial job characteristics, fatigue and psychological distress using three
instruments.
Results A total of 647 workers with mean age of 43.7 were completed. Probable fatigue was found in 34.6% of the sample. Fatigue was
found by multiple logistic regressions to be associated with the lack of exercise, working in shifts, depression score and
lack of social support at workplace.
Conclusions This study found associations between life style, psychosocial job characteristics and fatigue. Because the high prevalence
of probable fatigue was found in such small enterprises, the authors suggest that a short interview with some quick questionnaires
in health checkup for these small enterprise workers are helpful to early detect psychosocial and fatigue problems. 相似文献
65.
本文应用核磁共振法(NMR)测定了几种混合体系的 HLB 值与混合体系中各组分的 HLB 值。实验结果表明,混合体系中各组分在核磁共振图谱中的积分曲线高度也具有加和性。混合体系的 HLB 值是体系中各组分 HLB 值的加权平均值。因此,对混合体系的 HLB 值可以应用 NMR 法直接测定,也可应用 NMR 法测定各组分的 HLB值,通过计算求得,计算值与实测值完全一致。 相似文献
66.
F. Cotton O. Pellet F.-N. Gilly A. Granier L. Sournac O. Glehen 《European journal of surgical oncology》2006,32(10):1212-1216
AIM: Peritonectomy procedures with intraperitoneal chemohyperthermia are an effective but costly treatment for peritoneal carcinomatosis (PC). Consequently a proper selection of patients is necessary. We evaluated the benefit of MRI prior to surgery, in the detection of two of the main surgery contraindications: bulky mesenteric tumors and bladder implants. METHODS: Three experts retrospectively reviewed abdominal and pelvic MRI from 19 cases of surgically proved PC (ovary: 7; colorectal: 7; gastric: 2; pseudomyxoma peritonei: 2; appendix: 1). RESULTS: Mesenteric tumors were always identified as hypersignal masses on axial and coronal fat suppression gadolinium-enhanced T1 images (n=3). Three out of five bladder implants were detected. The two cases of bladder implants that were not detected on MRI were missed because the bladder was not filled. The best sequence for the detection of bladder involvement was axial T2-weighted images with bladder filling. CONCLUSIONS: Evaluating the preoperative resectability of PC is crucial for patient management. MRI seems to reliably detect bulky mesenteric tumors and bladder implants on condition the bladder is filled and appropriate sequences are used. 相似文献
67.
Bacterial ghosts (BGs) are empty bacterial envelopes of Gram-negative bacteria produced by controlled expression of cloned gene E, forming a lysis tunnel structure within the envelope of the living bacteria. BGs are devoid of cytoplasmic content and possess all bacterial bio-adhesive surface properties in their original state while not posing any infectious threat. BGs are ideally suited as an advanced drug delivery system (ADDS) for toxic substances in tumor therapy. The inner space of BGs can be loaded with either single components or combinations of peptides, drugs or DNA which provides an opportunity to design new types of (polyvalent) drug delivery vehicles. Uptake of BGs loaded with Doxorubicin (Dox) by CaCo2 cells led to effective Dox release from endo-lysosomal compartments and accumulation in the nucleus. Viability and proliferative capacity of the cells were significantly decreased (2–3 orders of magnitude) after internalization of Dox loaded BGs as compared to cells incubated with free Dox. The same effect was observed with leukemia cells. Melanoma cells also revealed a high capability to internalize BGs. These results indicate that BGs are able to target a range of types of cancer. BGs have also been investigated as DNA delivery vectors. Studies show DNA loaded BGs are efficiently phagocytosed and internalized by both professional APCs and tumor cells with up to 82% of cells expressing the plasmid-encoded reporter gene. Our studies with BGs as an ADDS system contribute (i) to optimize drug delivery for the treatment of cancer; (ii) define specific conditions for selection and preparation of BG formulations; (iii) and provide a background for the clinical application of BGs in cancer therapy. 相似文献
68.
69.
腰椎后路非融合固定系统的临床应用 总被引:11,自引:1,他引:10
复习腰椎后路非融合固定系统的设计原理、临床应用及治疗效果等相关文献,与传统的脊柱融合术相比,应用非融合系统可获得很好的疗效,并可以减少邻近节段退变的发生率。 相似文献
70.