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991.
This study extends laboratory-based profiles to participation in leisure activities for persons with three genetic syndromes. Parents of 223 persons with Prader-Willi, Williams, and Down syndromes filled out a newly developed Leisure Activities Questionnaire. Sixteen items loaded onto five distinct factors: social; visual-spatial; visual-strategy; musical; and physical activities. Individuals with Williams syndrome less often participated in visual-spatial activities, those with Prader-Willi syndrome more often performed both visual-spatial and visual-strategy activities, and those with Williams and Down syndromes more often performed musical activities. With increasing chronological ages, all groups increased in their social activities, while those with Williams and Down syndromes decreased in their visual-spatial activities. In both Prader-Willi and Williams syndrome, decreased maladaptive behaviors related to greater amounts of participation in etiology-related activities. Theoretical and practical implications are discussed.  相似文献   
992.
晚期肺癌的中医证候研究   总被引:18,自引:0,他引:18  
目的 探讨晚期肺癌的主要中医证候。方法 采用回顾性与前瞻性相结合的方法进行临床观察。结果 经 χ2 检验 ,不同中医证候的晚期肺癌组之间有显著性差异 (P <0 0 1) ,而血瘀证、气虚证、痰证、阴虚证最为多见 ;晚期非小细胞肺癌与晚期小细胞肺癌的中医证型没有显著性差异。结论 晚期肺癌的中医证候以血瘀证、气虚证、痰证、阴虚证为主 ;晚期非小细胞肺癌与小细胞肺癌的中医证候无明显差异。  相似文献   
993.
Besides clinical efficacy, the mechanisms of action of deep brain stimulation (DBS) are still debated. To shed light on this complex issue, we have taken the opportunity to record the response of globus pallidus internus (GPi) neurones to 100 Hz stimulations in a case of Lesch-Nyhan syndrome (LNS) where four pallidal electrodes were implanted. Three types of response were observed, 2/19 neurones were unaffected by DBS. About 7/19 neurones were inhibited during DBS stimulation and 10/19 neurones were excited during DBS stimulation. Both effects ceased when DBS was turned off. Inhibited neurones were situated lower that exited ones on the trajectory (1.25 and 4.65 mm above the center of GPi respectively). These observations suggest that locally DBS induces a reversible inhibition of neurone firing rate while at the same time distantly exciting the main afferents to and/or efferents from the GPi. Both actions would result in a strong GPi inhibition that does not preclude increased outflow from the GPi.  相似文献   
994.
目的探讨Tourette综合征(TS)患儿体感诱发电位(SEP)变化特征及其对脑功能损害程度及定位诊断的价值。方法对76例TS患儿(TS组)、20例精神发育迟滞(MR)患儿(MR组)和22例健康儿童(正常对照组)进行SEP检测,观察各组各波的潜伏期和形态改变。结果与正常对照组儿童相比,TS组N2、P3、N3波潜伏期延长,MR组P2、N2、P3波潜伏期延长,但均无显著性差异(P均>0.05);TS组和MR组与正常对照组儿童比较,N2、P3、N3波有缺失现象,差异有显著性意义(P均<0.01)。TS与MR组患儿的波形缺失均以右侧为甚,但两侧比较差异无显著意义(P>0.05)。结论TS患儿存在皮层及皮下脑功能损害,体感诱发电位可作为TS的辅助诊断指标。  相似文献   
995.
996.
We report a case of Noonan syndrome associated with central giant cell granuloma. The patient was a 101/2-year-old boy with the chief complaint of proptosis of the right eye. He also had various malformations such as short stature, webbed neck, pectus excavatum, cubitus valgus, pulmonary valve stenosis and patent foramen ovale, a characteristic face appearance and cryptorchidism and so on. Chromosome analysis showed a 46, XY karyotype. A computed tomographic scan and magnetic resonance imaging showed a mass originated from the lateral wall of the right maxillary sinus. The patient underwent Caldwell-Luc operation. Histological examination of the mass showed the characteristics of central giant cell granuloma. This case report describes a patient with the features of the recently described Noonan-like/multiple giant cell lesion syndrome.  相似文献   
997.
目的:探讨以脑立体定向术治疗震颤麻痹、癫痫、癌性疼痛、慢性精神病及颅内金属异物的方法和疗效。方法:用多功能脑立体定向仪对不同疾病毁损其不同的核团。结果:震颤麻痹166例共182次手术中治愈13例次,显效145例次,有效11例次,无效12例次,死亡1例,有效率达929%;癫痫18例,显效11例,有效4例,无效3例,有效率达833%;癌性痛疼5例均显效;精神病3例,显效2例,有效1例;颅内异物2例均治愈。结论:脑立体定向术对以上疾病均取得了较为满意及良好的疗效,总有效率达924%,并且比传统开颅术简便安全  相似文献   
998.
In a double-blind placebo-controlled cross-over study, 30 patients with Delayed Sleep Phase Syndrome (DSPS) were included, of whom 25 finished the study. Melatonin 5 mg was administered during two weeks in a double-blind setting and two weeks in an open setting successively or interrupted by two weeks of placebo. The study's impact was assessed by measurements of the 24-h curves of endogenous melatonin production and rectal temperature (n=14), polysomnography (n=22), actigraphy (n=13), sleep log (n=22), and subjective sleep quality (n=25). Mean dim light melatonin onset (DLMO) (±SD), before treatment, occurred at 23.17 hours (±138 min). Melatonin was administered five hours before the individual DLMO. After treatment, the onset of the nocturnal melatonin profile was significantly advanced by approximately 1.5 hour. Body temperature trough did not advance significantly. During melatonin use, actigraphy showed a significant advance of sleep onset and polysomnography, a significant decreased sleep latency. Sleep architecture was not influenced. During melatonin treatment patients felt significantly more refreshed in the morning. These results show that analysis of DLMO of patients suffering from DSPS is important both for diagnosis and therapy. These results are discussed in terms of the biochemistry of the pineal.  相似文献   
999.
急性心肌梗塞错误溶栓治疗12例分析   总被引:1,自引:0,他引:1  
自1993年12月至1995年8月,对155例急性心肌梗塞(AMI)病人进行溶栓治疗,12例发生误溶(7.7%)。其中早期复极综合征4例,室壁瘤2例,心肌炎1例,心肌病1例,完全性左束支阻滞1例,间歇性左前分支阻滞互例,其它2例。本文分析了误溶病例与AMI的鉴别要点,并提出了减少误溶,提高诊疗水平的措施。  相似文献   
1000.
哈尔滨市动力区7—10岁儿童多动症流行病学调查   总被引:7,自引:0,他引:7  
目的了解市动力区7~10岁儿童多动症的发病情况及其有关因素。方法采用分层整群抽样法对1377名儿童进行多动症的流行病学调查,主要以DSM—Ⅲ中的ADD诊断标准为参考综合诊断病例。结果多动症检出率为6.89%(95例/1377);父母为工人、父文化为小学或文盲的,检出率最高,分别为7.34%、7.72%及8.77%;父母大学文化的检出率最低(5.16%和2.83%);母孕期经受负性生活事件及家庭环境不良是多动症发病的危险因素。结论哈市动力区7~10岁多动症检出率较高;与发病有关的因素复杂多样。  相似文献   
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