Validity and reliability of two muscle strength scores commonly used as endpoints in assessing treatment of myasthenia gravis

Valid and reliable measurements of muscle impairment are needed to assess therapeutic efficacy in patients with generalized myasthenia gravis (MG). In 22 patients we compared the validity and interobserver reliability of two scoring methods commonly used as main endpoints in clinical trials, i.e., the Myasthenic Muscle Score (MMS) ranging from 0 to 100 (normal) and the Quantified Myasthenia Gravis Strength Score (QMGSS) ranging from 0 (normal) to 39. Each score is correlated more with functional scale and less with the patient's self-evaluation. Using intraclass correlation we found strong agreement between observers for both the MMS (r = 0.906) and the QMGSS (r = 0.905). The correlation between MMS and QGMSS was high (r = 0.87). The reliability of neither score depended on any specific item, since the removal of individual items did not significantly alter the intraclass correlation coefficient (ranging from 0.86 to 0.93).     

A multi-dimensional model of clinical utility.

Clinical utility is an increasingly used concept in health care, but one that lacks an agreed formal definition or conceptualization. In this article, I show that the term is commonly used as a synonym for studies of clinical effectiveness and/or economic evaluations and argue that further factors relating to everyday working practice should be included under its auspices. I go on to develop a multi-dimensional model that outlines four factors in practitioners' judgements about clinical utility: appropriateness, accessibility, practicability, and acceptability.     

创新办刊机制力争做大做强--《医疗卫生装备》五年办刊实践与展望

《医疗卫生装备》杂志自2001年机构改制以来,坚持以质量建设为中心,不断强化品牌意识、服务意识,不断提升刊物质量,拓宽办刊范围,实现了军事效益、社会效益和经济效益的全面提升.回顾了《医疗卫生装备》杂志5年来的办刊发展历程,探索了其未来发展前景,对加快期刊发展,落实新的奋斗目标,有一定的参考作用.     

肺通气量动态测量机理的研究

作者介绍了新型动态肺通气量计实现肺通气量实时动态测量的方法与原理。新型动态肺通气量计设计为发射与接收两部分,可以实现远距离不间断遥测,采集劳动者劳动全过程的肺通气量数据,被测试者负荷小,不受测试干扰。所采集数据客观、完整,可靠性高。     

Mode of delivery and pelvic floor muscle strength and sexual function after childbirth.

OBJECTIVE: To investigate the respective roles of the mode of delivery and strength of pelvic floor muscles in the sexual function of women. METHOD: Thirty-two women who were delivered vaginally and 21 women who underwent cesarean delivery at the Celal Bayar University School of Medicine Obstetrics Department were enrolled in the study, and 15 nulliparas were recruited as controls. Sexual function was assessed in all women by a validated questionnaire (the Female Sexual Function Index). Desire, arousal, lubrication, orgasm, satisfaction, and pain were measured separately, and pelvic floor muscle strength was assessed by a perineometer. Sexual function was compared among the 3 groups. The correlation between pelvic floor muscle strength and sexual function was also investigated. RESULTS: Pelvic floor muscle strength was significantly lower in the group vaginally delivered compared with the group delivered by cesarean section and the nulliparous group (P<0.05). There was no difference between the groups regarding sexual function (P>0.05), and there was also no correlation between sexual function and pelvic muscle strength. CONCLUSION: Pelvic floor muscle strength and mode of delivery did not affect sexual function in our study participants. The muscular component of female sexual function should be further investigated.     

抓创新能力培养 促博士学位论文质量

通过回顾、分析1999年以来我院所获得的3篇全国优秀博士论文,总结院所博士研究生培养的经验和做法,认为在研究生教育过程中必须始终抓住培养创新精神和能力这根主线,加强学科建设和师资队伍建设,进而促进博士学位论文质量的提高。     

通识教育:知识、学科、制度整合的新范式

本文以岭南大学、哈佛大学、京都大学通识教育的最新发展为案例，通过对知识、学科、制度三者的关系及其对大学课程改革的作用的分析，认为在新世纪，知识的发展变化促使学科也发生了相应的变化，进而使大学的院系组织制度也出现了新的变化。通识教育也随之发生变化。通过实施通识教育，将对知识、学科、制度进行新的整合，是大学教学改革的新的目标和任务。     

饮食从业人员华支睾吸虫病防治知识水平调查

目的 了解江门市饮食从业人员对肝吸虫病防治知识掌握情况，制定健康教育对策。方法随机抽查565名饮食从业人员进行问卷调查。结果肝吸虫病知识晓率为34．16％，肝吸虫对人体危害的知晓率为18．05％．肝吸虫感染途径的知晓率为29．73％，如何预防肝吸虫的知晓率为30．27％。结论饮食从业人员肝吸虫病防治知识掌握甚少，应加强这方面的健康教育。     

文献检索课的特点及在大学生知识构建中的作用

从文献检索课培养大学生创新精神、信息素养、思维方式、独立学习能力四个方面阐述其特点及在弥补当代大学教育不足之处的作用,浅析医学文献检索课对医学生在校期间及毕业后信息获取,科学构建知识结构的影响.     

家长营养知识和态度对子女饮食行为的影响

目的了解家长营养知识和态度对子女饮食行为的影响程度，为有针对性地对其进行营养教育提供科学依据。方法采用问卷调查法对深圳市300名学龄儿童及其家长进行营养知识、态度、行为的调查。结果家长对儿童营养知识普遍缺乏，大部分学龄儿童存在着不同程度的各种不良饮食习惯，如不吃早餐、吃零食、挑食、偏食、进食速度过快和膳食搭配不合理等。结论家长的营养知识和态度对子女饮食行为和食物消费结构有明显影响；但家长和学生接受营养知识的态度较好，说明在家长和学生中开展有针对性地营养健康教育是非常必要和可行的。