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81.
Takashi Toyonaga Eisei Nishino Takashi Hirooka Chie Ueda Kazu Noda 《Digestive endoscopy》2006,18(Z1):S123-S127
To control intraoperative bleeding is an important key to successful endoscopic submucosal dissection. The distribution of submucosal vessels encountered during the procedure differ in places in the stomach and are roughly categorized into three groups: those located in the antrum, those in the lesser curvature, and those on the anteroposterior corpus wall which consists of oblique muscle layers. Therefore, knowledge of a suitable setting of diathermy and adjusted depth of dissection in the submucosal layer for each site is imperative. The combination of utilizing the distal attachment forced or swift coagulation (trimming with coagulation mode) have enable the treatment with an insulation tipped knife safer. 相似文献
82.
Yi Li Kevin McIntosh Jieli Chen Chunling Zhang Qi Gao Jade Borneman Kim Raginski James Mitchell Lihong Shen Jing Zhang Dunyue Lu Michael Chopp 《Experimental neurology》2006,198(2):313
We evaluated the effects of allogeneic bone marrow stromal cell treatment of stroke on functional outcome, glial–axonal architecture, and immune reaction. Female Wistar rats were subjected to 2 h of middle cerebral artery occlusion. Rats were injected intravenously with PBS, male allogeneic ACI – or syngeneic Wistar –bone marrow stromal cells at 24 h after ischemia and sacrificed at 28 days. Significant functional recovery was found in both cell-treated groups compared to stroke rats that did not receive BMSCs, but no difference was detected between allogeneic and syngeneic cell-treated rats. No evidence of T cell priming or humoral antibody production to marrow stromal cells was found in recipient rats after treatment with allogeneic cells. Similar numbers of Y-chromosome+ cells were detected in the female rat brains in both groups. Significantly increased thickness of individual axons and myelin, and areas of the corpus callosum and the numbers of white matter bundles in the striatum were detected in the ischemic boundary zone of cell-treated rats compared to stroked rats. The areas of the contralateral corpus callosum significantly increased after cell treatment compared to normal rats. Processes of astrocytes remodeled from hypertrophic star-like to tadpole-like shape and oriented parallel to the ischemic regions after cell treatment. Axonal projections emanating from individual parenchymal neurons exhibited an overall orientation parallel to elongated radial processes of reactive astrocytes of the cell-treated rats. Allogeneic and syngeneic bone marrow stromal cell treatment after stroke in rats improved neurological recovery and enhanced reactive oligodendrocyte and astrocyte related axonal remodeling with no indication of immunologic sensitization in adult rat brain. 相似文献
83.
血小板第4因子对辐射损伤小鼠免疫功能的保护作用 总被引:1,自引:0,他引:1
目的:探讨血小板第4因子(plateletfactor4,PF4)对辐射损伤小鼠免疫系统的影响。方法:雄性BALB/c小鼠随机分为3组,第1组(单纯照射组)、第Ⅱ组(PF4保护组)、第Ⅲ组(正常对照组),第Ⅱ组在照射前26h及20h腹腔注射PF440μg/kg,全身一次性5Gy60Co—γ射线照射后瑞氏染色法计数外周血淋巴细胞百分数。胸腺、脾脏制成细胞悬液计数后,MTT比色法测定胸腺及脾细胞增殖能力。结果:第Ⅱ组小鼠外周血淋巴细胞百分数下降趋势较第1组明显减慢。胸腺、脾细胞计数,第Ⅱ组明显高于第1组。淋巴细胞增殖试验,第Ⅱ组与第1组相比,小鼠胸腺及脾细胞的增殖能力明显增强。结论:PF4对免疫系统有辐射保护作用,可明显增强辐射损伤小鼠的免疫功能。 相似文献
84.
Eugénie C.H. van den Ham Jeroen P. Kooman Annemie M.W.J. Schols Fred H.M. Nieman Joan D. Does Frits M.E. Franssen Marco A. Akkermans Paul P. Janssen Johannes P. van Hooff 《American journal of transplantation》2005,5(8):1957-1965
Exercise intolerance is common in hemodialysis (HD) and renal transplant (RTx) patients. Aim of the study was to assess to what extent exercise capacity and skeletal muscle strength of RTx patients differ from HD patients and healthy controls and to elucidate potential determinants of exercise capacity in RTx patients. Exercise capacity, muscle strength, lean body mass (LBM) and physical activity level (PAL) were measured by cycle-ergometry, isokinetic dynamometry, DEXA and Baecke Questionnaire, respectively, in 35 RTx, 16 HD and 21 controls. VO2peak and muscle strength of the RTx patients were significantly lower compared to controls (p<0.01), but not different compared to HD patients. In RTx patients, strength (p<0.001), PAL (p=0.001) and age (p=0.045) were significant predictors of VO2peak. Muscle strength was related to LBM (p=0.001) and age (p=0.001), whereas gender (p<0.001) and renal function (p=0.01) turned out to be significant predictors of LBM. No effects of corticosteroids were observed. Exercise capacity and muscle strength seem equally reduced in RTx and HD patients compared to controls. In RTx patients, muscle strength and PAL are highly related to exercise capacity. Renal function appears to be a significant predictor of LBM, and through the LBM, of muscle strength and exercise capacity. 相似文献
85.
86.
目的 探讨静脉输注供者特异性抗原联合抗白细胞介素2受体(IL 2R)γ链单克隆抗体诱导移植免疫耐受的可行性。方法 在C57BL/6小鼠建立H Y皮肤移植模型,术前7 d给予5×106个供者脾细胞静脉输注,并分别于术前6 d和4 d给予抗白细胞介素2受体γ链单克隆抗体(4G3、3E12及TUGm2各0.5 mg)和抗IL 2Rβ单克隆抗体(TM β1,0.5 mg)混合液2.0 mg腹腔注射,以单纯行H Y皮肤移植模型和静脉输注供者特异性抗原的H Y皮肤移植模型为对照,观察皮肤移植物的存活时间。结果 联合给予抗白细胞介素2受体γ链单克隆抗体和供者特异性抗原输注组的皮肤移植物存活时间均超过100 d,显著长于单纯H Y皮肤移植组的33.42 d(P<0.01)及仅输注供者特异性抗原H Y皮肤移植组的14.71 d(P<0.01)。结论 在H Y皮肤移植模型中,静脉输注供者特异性抗原联合抗白细胞介素2受体γ链单克隆抗体可以成功地诱导受者对皮肤移植物的免疫耐受。 相似文献
87.
88.
感染日本血吸虫的家兔治疗前后肝纤维化动态观察 总被引:1,自引:1,他引:0
感染日本血吸虫的家兔治疗前后肝纤维化B超声像图模型、血清MAO水平及病理学结果表明,血吸虫引起的肝纤维化变化过程与血清MAO水平升降趋势趋向一致,均在18周达到高峰。解剖与病理学检查结果基本相符,血吸虫性肝纤维化形成后,只要及时给予杀虫治疗,肝纤维化部分可发生逆转。 相似文献
89.
运用文献计量分分析法对本刊1992-1995年16期所刊文章作了分析。结果:致突变的文章较多;每篇文章作者平均3.94人,大多集中在高等院校及科研机构,地区分布较广,高产作家尚少;平均引文8.22篇,引文以中、英文期刊为主;文献半衰期为中文4.16年,英文6.93年;有8种核心期刊;自引率较高。与创刊后的前12期(1989-1992)相比:一次性文献比重明显增加,致畸文章比重增加,高产作家相对增多,英文引文增加,英文半衰期缩短近二年半,提示刊物水平有提高趋势。 相似文献
90.
C3d及荷C3d免疫复合物的测定与意义 总被引:2,自引:0,他引:2
用抗人C3和抗人IgGγ球蛋白组分作固相反应物,建立了检测补体活化片段C3d及荷C3d-IC的ELISA法,并对临床各类疾病患者血清C3d和C3d-IC的水平进行了测定,结果表明:慢性肾炎,SLE,慢性乙肝及肺炎患者血清C3d总体水平均较对照组显著增高,分别有58.5%~72.2%的病人C3d含量高于正常上限(P〈0.01),且该类病人亦有较高的C3d-IC阳性检出率(肺炎患者例外)本项研究中,C 相似文献