经直肠超声引导前列腺穿刺活检203例临床分析

目的评估经直肠超声引导的前列腺六针穿刺活检在前列腺癌及前列腺其他疾病的诊断和鉴别诊断的价值。方法对指肛检查阳性，血清PSA〉4pg／L及经直肠超声检查前列腺声像图异常怀疑有占位性病变的203人进行经直肠超声引导的前列腺穿刺活检。结果穿刺活检的203例病理结果：良性前列腺增生（BPH）104例占51．24％，前列腺癌（PCa）95例占46．80％，前列腺结核及前列腺平滑肌肉瘤各2例，分别占0．98％。结论经直肠超声引导的前列腺穿刺活检其操作简单，病人痛苦小，并发症少，较安全。在前列腺癌及其他前列腺疾病的诊断与鉴别诊断中有重要的临床价值。     

急性脑出血患者血清谷氨酸动态变化分析

目的通过观察脑出血（intracerebral hemorrhage，ICH）患者血清中谷氨酸的动态变化来进一步评价谷氨酸对脑出血的作用。方法选择符合条件的30例急性高血压脑实质出血患者，给予神经内科脑出血常规治疗，采用高效液相色谱法检测起病后2d内、5．6d、8-9d和15．16d的血清谷氨酸浓度，同步进行神经功能评定，同时于发病后1．3d、d5-6d及d15．16行头部CT检查了解血肿体积大小。结果脑出血患者血中谷氨酸浓度与血肿体积及神经功能缺损评分之间呈正的直线相关。经治疗后，所有病例谷氨酸水平迅速下降，在5-6d和8—9d下降速度更加明显。结论谷氨酸可能参与了自发性脑出血患者的急性期脑损伤作用。     

40例胃占位病变的X线及超声诊断

分析了经病理证实的４０例胃占位病变的Ｘ线及超声资料，旨在探讨超声及其与Ｘ线结合在胃占位病变中的价值。结果提示，超声和Ｘ线各有优缺点，二者结合使用，可互相取长补短，对提高胃占位病变的诊断质量，帮助临床制定合理的治疗方案有肯定价值。     

高压液相色谱纯化肾综合征出血热病毒血凝素及其性状分析

用吐温８０－乙醚（ＴＥ）法、蔗糖－丙酮（ＳＡ）法、丙酮－乙醚（ＡＥ）法分别从肾综合征出血热病毒（ＨＦＲＳＶ）感染的Ｖｅｒｏ－Ｅ６细胞培养和乳小白鼠脑组织中制备病毒血凝素（ＨＡＮ），定量对比证明其制备效果，结果无明显差异。粗制ＨＡＮ经高压液相色谱（ＥＰＬＣ）纯化，有４个洗脱峰，血凝活性物质存在于峰１。纯化ＨＡＮ在ＳＤＳ－ＰＡＧＥ中呈单一区带，分子量５６．６ＫＤ，ＨＡＮ相对含量７９．６％。纯化ＨＡＮ在蔗糖密度梯度液中有一条１．１５～１．１６ｇ／ｃｍ３的沉淀，粗制ＨＡＮ有３条沉淀。电镜观察纯化ＨＡＮ中为大小相等的球状颗粒。粗制ＨＡＮ的高密度沉淀中可见到病样颗粒。对几种常用消毒剂、氧化剂、去垢剂对ＨＡＮ的灭活作用做了实验对比观察。     

PHA RMA COKINETICS OF CUPRIC－BIS（SALICYLALDEHYDE－2－FURA NTHIOCA RBOXY－HYDRAZONATE） DICHLORIDE（CSFTCH） IN RABBITS

ＰＨＡＲＭＡＣＯＫＩＮＥＴＩＣＳＯＦＣＵＰＲＩＣ－ＢＩＳ（ＳＡＬＩＣＹＬＡＬＤＥＨＹＤＥ－２－ＦＵＲＡＮＴＨＩＯＣＡＲＢＯＸＹ－ＨＹＤＲＡＺＯＮＡＴＥ）ＤＩＣＨＬＯＲＩＤＥ（ＣＳＦＴＣＨ）ＩＮＲＡＢＢＩＴＳ￥ＧａｏＹｕｎｓｈｅｎｇ；ＺｈｕＹｕｙｕｎ（...     

Ultrasound biomicroscopic features of spherophakia

Background: Spherophakia is an uncommon diagnosis. This is the first case report of spherophakia evaluated by ultrasound biomicroscopy.
Methods: Ultrasound biomicroscopy is a new diagnostic technique developed by one of the authors and provides images with microscopic resolution of the anterior segment. A patient with spherophakia was evaluated by ultrasound biomicroscopy (Zeiss-Humphrey, 50MHz) before and after YAG laser iridotomy.
Results: Ultrasound biomicroscopic assessment revealed a shallow anterior chamber, a very steep anterior lens curvature, iridolenticular contact, elongated zonules, and an increased distance between the lens equator and the ciliary processes. Angle closure glaucoma was due to a pupil block mechanism. The pupil block was relieved by YAG laser iridotomy.
Conclusions: Ultrasound biomicroscopy is a useful technique to confirm the diagnosis of spherophakia. The pupil block in spherophakia is relieved by YAG laser iridotomy.     

甲状腺肿瘤X线造影与超声检查对比分析

本文报告了经手术病理证实的53例甲状腺肿瘤,均作了甲状腺造影和B超检查.通过比较分析,我们认为造影对确定肿瘤的良、恶性以及延伸到胸骨后的异位甲状腺肿瘤有其优越性,是一项有效的检查方法;超声则能准确地判断肿瘤的囊、实性,适合碘过敏患者的检查.两种检查各有特点,配合使用有利于对甲状腺肿瘤的诊断和治疗.     

Pulsatility and resistance indices in intrarenal arteries of normal adults

In order to establish the normal range of values of Pulsatility (PI) and Resistance (RI) Indices in the intrarenal vasculature, a study of 50 healthy volunteers (23 males, 27 females), divided into five groups of 10 according to age, was performed with Duplex Doppler ultrasound. Both kidneys were examined in all individuals and, in 12, indices were also compared between upper and lower poles of both kidneys. In addition, repeat examinations were performed in nine subjects on three different days, in order to assess the reproducibility of the method. No differences were found in the mean values of both indices between males and females, upper and lower poles, right and left kidneys. A statistically significant increase (p < 0.01, unpaired t-test) was demonstrated when the oldest age group (7th decade) was compared to the youngest age group (3rd decade). The method appeared remarkably reproducible for RI (4.2–7%), with wider variation in the PI (9.5–22.7%).     

高效液相色谱法测定硫酸奈替米星注射液的含量

目的采用高效液相色谱法测定硫酸奈替米星及注射液的含量。方法以μ-Diamonsil—C18为分析柱，流动相为1．5％的磷酸二氢钾-乙睛，流速为1．0ml／min，检测渡长为205nm。含量测定用峰面积外标法。结果硫酸奈替米星在0．1—1．6mg／ml浓度范围内呈现良好线性关系，r=0．9998．平均回收率为99．5％，RSD=0．4％（n=9）。结论本方法操作简便、快速，结果准确可靠，重现性好，均能很好地满足质量控制的要求，为开辟氨基糖苷类抗生素含量测定的仪器提供了一定借鉴。     

肿胀法外超声吸脂术的组织学研究

目的 观察外超声能量作用于活体组织后的组织学变化，以探索其作用机制。方法 对3只家猪腹部两侧进行外超声与非超声比较，作用不同时间后在光镜和电镜下观察其皮肤组织全层的变化。结果 在外超声作用18min内，随着作用时间的延长，猪的皮下脂肪组织和生物大分子结构的破坏程度不断加重，脂肪组织中产生的空泡不断增大而皮肤组织及血管无明显变化。结论 外超声吸脂术可通过稳定的空泡效应选择性地使脂肪细胞结构发生不可逆的坏死性改变，这一改变与作用时间成正比。