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991.
本文报告了36例研究对象肺廓清~(131)I-三甲基羟基-间碘-苯二胺(~(131)I-HIPDM)结果,其中31例作了常规肺功能及动脉血气检查。结果表明不同组间肺廓清~(131)I-HIPDM速率不同,能形成一个新的肺功能障碍指数。右肺廓清~(131)I-HIPDM快相与用力肺活量(FVC)、第1秒用力呼气量(FEV_1)、功能残气量(FRC)、残气量(RV)肺总量(TLC)相关P<0.01;与最大呼气流量(PEFR)、肺活量(VC)、最大通气量(MVV)、动脉血氧分压(PaO_2)相关P<0.05。肺廓清~(131)I—HIPDM速率反映了肺功能状态,对疾病分期及早期肺功能损伤检测优于常规肺功能。 相似文献
992.
乙型肝炎病毒免疫逃避株表面抗原决定簇编码区的序列分析 总被引:2,自引:0,他引:2
应用聚合酶链反应(PCR)产物直接测序,在国内首次发现1例持续高滴度乙型肝炎表面抗原(HBsAg)和抗一HBs共存者携带的乙型肝炎病毒DNA第532位碱基A被G取代,推导其“a”决定簇中第126位苏氨酸被丙氨酸取代,提示该株“a”决定簇第一个结构环疏水性增加,由此可能导致其抗原性改变,而诱发免疫逃避株形成。 相似文献
993.
S Nishijima T Sugimachi T Higashida Y Asada K Okuda K Murata 《The Journal of dermatology》1992,19(6):356-361
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important causative microorganisms for nosocomial infections. Recently, the incidence of isolation of MRSA has been increasing every year in Japan and is, notably, much more frequently found in inpatients than in outpatients. Therefore, we have done epidemiological studies of MRSA isolated from medical staff, inpatients, and the hospital environment in one ward of our hospital. Thereafter, we examined the antibiotic susceptibility (ABPC, DMPPC, CET, CMZ, IPM, GM, MINO, OFLX, EM, CLDM, VCM), phage typing, and coagulase typing of these MRSA. MRSA were isolated more frequently from anterior nares of inpatients than from doctors and nurses. MRSA were isolated more frequently from the environment near carriers of MRSA. Coagulase type II and phage type N.T. (not typable) were the dominant types of MRSA in our hospital (69% and 61%). MRSA strains were resistant to most antibiotics with a few exceptions (VCM, IPM, CMZ, CET). The high isolation frequency of MRSA in our hospital seems to suggest that inpatients who are carrying MRSA spread MRSA throughout the hospital environment and that the anterior nares of inpatients are the major MRSA harbor. 相似文献
994.
D. MacDonald E. Lau E. L. P. Chan T. Mak J. Woo P. C. Leung R. Swaminathan 《Calcified tissue international》1992,51(6):412-414
Summary Serum intact parathyroid hormone (PTH), 25 hydroxyvitamin D(25OHD), 1,25 dihydroxyvitamin D (1,25(OH)2D), albumin, and ionized calcium were measured in 61 Chinese female patients with hip fracture and 61 control subjects. Hip fracture patients had low albumin, ionized calcium, and 250HD levels. Serum PTH and 1,25 (OH)2D values were not different between the two groups. We conclude that although 250HD level in hip fracture patients is low, there is no evidence of secondary hyperparathyroidism, suggesting that the low 250HD levels may be a secondary phenomenon in response to the fracture. 相似文献
995.
A. Gustavo Gonzlez M. Angeles Herrador Agustín G. Asuero 《International journal of pharmaceutics》1995,120(2):215-220
The capacity factors (k′) of seven β-adrenoceptor blocking agents in six different reversed-phase HPLC systems have been determined. Octanol-aqueous buffer (pH 7.4) partition constants (P) for these blocking agents were also obtained. By using target factor analysis (TFA), good empirical correlations between the log k′ and log P were derived. The resulting hydrophobicity order agrees well with the metabolic elimination pathways of these drugs. 相似文献
996.
S. H. Sindrup L. Arendt-Nielsen K. Brøsen P. Bjerring H. R. Angelo B. Eriksen L. F. Gram 《European journal of clinical pharmacology》1992,42(6):587-591
Summary We have studied the hypoalgesic effect of codeine (100 mg) after blocking the hepatic O-demethylation of codeine to morphine via the sparteine oxygenase (CYP2D6) by quinidine (200 mg). The study was performed in 16 extensive metabolizers of sparteine, using a double-blind, randomized, four-way, cross-over design. The treatments given at 3 h intervals during the four sessions were placebo/placebo, quinidine/placebo, placebo/codeine, and quinidine/codeine. We measured pin-prick pain and pain tolerance thresholds to high energy argon laser stimuli before and 1, 2, and 3 h after codeine or placebo.After codeine and placebo, the peak plasma concentration of morphine was 6–62 (median 18) nmol·.l–1. When quinidine pre-treatment was given, no morphine could be detected (<4 nmol·l–1) after codeine. The pin-prick pain thresholds were significantly increased after placebo/codeine, but not after quinidine/codeine compared with placebo/placebo. Both placebo/codeine and quinidine/codeine increased pain tolerance thresholds significantly. Quinidine/codeine and quinidine/placebo did not differ significantly for either pin-prick or tolerance pain thresholds.These results are compatible with local CYP2D6 mediated formation of morphine in the brain, not being blocked by quinidine. Alternatively, a hypoalgesic effect of quinidine might have confounded the results. 相似文献
997.
Levels of cardiovascular risk factors were determined in 75 patients with Type 2 diabetes mellitus. The patients were divided into three groups according to their urinary protein excretion (UPE): (a) normal proteinuria (less than or equal to 70 mg d-1); (b) microproteinuria (70-500 mg d-1); and (c) macroproteinuria (greater than 500 mg d-1). A significant stepwise increase in mean systolic blood pressure, LDL-cholesterol and fibrinogen levels was observed from the first to the third investigated group of patients. Mean apoprotein B levels were significantly increased in the group with macroproteinuria compared to the other two groups. Significant linear correlations were found between UPE and LDL-cholesterol, total cholesterol, apoprotein B, creatinine, systolic blood pressure and diabetes duration. In summary, it is concluded that the levels of some cardiovascular risk factors increase with the stage of proteinuria in Type 2 diabetes mellitus. 相似文献
998.
Treatment of chronic hepatitis B 总被引:3,自引:0,他引:3
A. S. F. Lok 《Journal of viral hepatitis》1994,1(2):105-124
SUMMARY. Chronic infection with the hepatitis B virus (HBV) is a major cause of worldwide morbidity and mortality. A large number of therapeutic approaches has been tried, including interferon (IFN), nucleoside analogues and immunomodulators. To date controlled clinical trials have shown that only IFN is of long-term value but many patients fail to respond to treatment. New approaches to treating patients with IFN-resistant hepatitis B are currently undergoing clinical and experimental evaluation, and it seems likely that new therapeutic agents will be available in the near future. 相似文献
999.
Detection of Epstein Barr virus in an hepatic leiomyomatous neoplasm in an adult human immunodeficiency virus 1-infected patient 总被引:5,自引:0,他引:5
S. Prévot J. Néris P. P. de Saint Maur 《Virchows Archiv : an international journal of pathology》1994,425(3):321-325
We report the first case of a human immunodeficiency virus (HIV)-related primary hepatic leiomyoma in an adult patient. The diagnosis was made at autopsy and confirmed by immunohistochemistry. Epstein Barr virus (EBV) was identified in tumour cells by in situ hybridization. Review of the literature revealed 13 cases of visceral myogenic tumours occuring in acquired immunodeficiency syndrome children, and only 2 cases in adults. One was a spinal epidural leiomyoma, the other multiple smooth muscle tumours of the colon and adrenal gland. This is the first report of EBV in smooth muscle neoplastic cells in an HIV-infected adult patient. 相似文献
1000.
甲硫氨酸脑啡肽对抗体的产生和T细胞免疫功能具有调节作用。为了明确这种作用机制,本实验观察了抗体和白细胞介素-2(IL-2)的产生和基因表达。甲硫氨酸脑啡肽对3F3杂交瘤细胞的抗体产生及其轻链和重链基因表达影响不明显。较高浓度的甲硫氨酸脑啡肽(0.1nmol·L ̄(-1)-1μmol·L(-1))不仅促进IL-2的产生和IL-2mRNA的转录,而且能提高IL-2mRNA的稳定性。 相似文献