基于智能化平台的医院配电系统安全探讨

结合实例,对医院建设配电安全平台的需求进行分析,阐述了配电安全平台的开发思路及系统功能,总结出应用配电智能化系统的成效.     

和厚朴酚在大鼠体内药动学及唾液分布研究

目的：探讨和厚朴酚静脉注射给药后在大鼠体内的动态变化规律及其在唾液中的分布情况。方法：大鼠尾静脉注射和厚朴酚,用反相高效液相色谱法测定和厚朴酚在血浆、唾液中的浓度,采用药动学软件3 P97分析数据,确定药动学参数。结果：和厚朴酚在大鼠体内符合二室模型分布,主要药动学参数：t1／2＝（102．980±10．600） min,AUC＝（1219．260±120．520）μg· min／mL,Vc＝（0．722±0．027） L／kg, CL＝（0．0246±0．002）L／min。结论：和厚朴酚可在唾液中检测到,给药后腮腺、颌下腺中的药物浓度与血浆中的药物浓度有一定的相关性。表明腮腺和颌下腺唾液样本将来可被用于和厚朴酚的治疗监测。     

Clinical imaging of macular pigment optical density and spatial distribution

Clinical research continues to provide an increasing number of studies that reveal an association between macular pigment optical density (MPOD) and both visual function and ocular health. As a result, there is a growing need for repeatable, accurate measures of MPOD that can describe peak optical density as well as spatial distribution. Measurement of MPOD in a research setting has an established history encompassing a number of both objective and subjective techniques. Transition of these techniques to a clinical setting has produced an array of commercial devices using three primary methods: heterochromatic flicker photometry, fundus autofluorescence and fundus reflectometry. The inherent differences among the techniques create difficulty in making direct comparisons between MPOD measurement devices. Understanding the limitations of each technique is critical in the clinical interpretation of MPOD results. Here, both the objective and subjective methods of MPOD measurement are reviewed with emphasis on the commercially available devices used in clinical settings.     

Pharmacokinetics,biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration

Context: Isoliquiritigenin (ISL) has been shown to exhibit a variety of biological activities. However, there is little research on the pharmacokinetic behavior and tissues distribution of ISL.

Objective: Pharmacokinetics, biodistribution and bioavailability of ISL after intravenous and oral administration were determined by systematic investigation in Sprague–Dawley rats.

Materials and methods: ISL was dissolved in medicinal ethanol-Tween 80–0.9% sodium chloride saline in a volume ratio of 10:15:75. The ISL solution was injected in rats via a tail vein at a single dose of 10, 20 and 50?mg/kg and administered orally in rats at a single dose of 20, 50 and 100?mg/kg, respectively. Blood samples were collected at time intervals of 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 6, 8 and 12?h after intravenous injection. Tissues of interests in mice were collected immediately at each determined time point (0.5, 1, 2, 3 and 6?h) after cervical dislocation.

Results: The dose-normalized AUC values were 7.3, 7.6 and 8.7?μg?×?h/ml (calculated based on the dose of 10?mg/kg) for intravenous doses of 10, 20 and 50?mg/kg, respectively. The elimination half-lifes (t_1/2λ) were 4.9, 4.6 and 4.8?h at 10, 20 and 50?mg/kg intravenous doses, respectively. The F values were 29.86, 22.70, 33.62% for oral doses of 20, 50 and 100?mg/kg, respectively. Liver, heart and kidney were major distribution tissues of ISL in mice. The plasma protein binding of ISL in rats was 43.72%.

Conclusion: The work may useful for further study of the bioactive mechanism of ISL.     

Red blood cell distribution width at admission predicts outcome in critically ill patients with kidney failure: a retrospective cohort study based on the MIMIC-IV database

PurposeWe aimed to explore whether red blood cell distribution width (RDW) could serve as a biomarker to predict outcomes in critically ill patients with kidney failure in this study.Materials and methodsThis retrospective study was conducted with the Medical Information Mart for Intensive Care IV (MIMIC-IV).A total of 674 patients were divided into three groups based on tertiles of RDW. We used the generalized additive model, Kaplan–Meier curve, and Cox proportional hazards models to evaluate the association between RDW and clinical outcomes. We then performed subgroup analyses to investigate the stability of the associations between RDW and all-cause mortality.ResultsNonlinear and J-shaped curves were observed in the generalized additive model. Kaplan–Meier analysis showed that patients with elevated RDW had a lower survival rate. The Cox regression model indicated that high levels of RDW were most closely associated with ICU mortality and 30-day mortality (HR = 4.71, 95% CI: 1.69–11.64 and HR = 6.62, 95% CI: 2.84–15.41). Subgroup analyses indicated that the associations between RDW and all-cause mortality were stable.ConclusionsElevated levels of RDW were associated with an increased risk of all-cause mortality, and RDW could be an independent prognostic factor for kidney failure.     

Analysing the Porosity Distribution in Stone Surfaces by Means of Unilateral NMR after Long-Term Outdoor Weathering

Porosity changes in the near-surface area of sandstones due to long-term weathering can produce deterioration. Therefore, porosity analyses on weathered sandstones are significant for detecting possible influences on the pore structure. Classical methods for determining the porosity and pore size distribution in sandstones can only investigate the entire sample volume. In contrast, in this publication, the porosity was analysed in 0.2 mm steps over a depth of 5 mm by means of single-sided NMR measurements on water-saturated sandstones under vacuum. Evaluations of Obernkirchener and Schleeriether Sandstones that were weathered outdoors in Germany for over 30 years are presented. The results showed that the water content in Vol.-% strongly correlated with the normalised NMR signal. The unweathered sandstones showed a uniform distribution of micro and capillary pores throughout the stone depth. As a result of 30 years of outdoor weathering, changes in the pore structure occurred at the sandstone surface due to weathering down to depths of about 0.6 mm. The porosity of the Schleeriether Sandstone samples, mainly the microporosity, clearly increased in this region. Due to the dominance of capillary pores in the Obernkirchener Sandstone, the changes were not as pronounced, but a shift towards smaller pores in the surface area was observable.     

Coronary artery lesion distribution in patients with chronic kidney disease undergoing percutaneous coronary intervention

PurposeTo determine the location of coronary atherosclerosis distribution observed in patients with chronic kidney disease (CKD).MethodsA cross-sectional study was conducted using the database of cardiovascular medicine data from Saitama Sekishinkai Hospital to clarify the association between renal function and angiographic characteristics of coronary atherosclerosis. In total, 3268 patients who underwent percutaneous coronary intervention were included. Propensity score matching revised the total to 1772. The association of renal function with the location and/or distribution of coronary atherosclerosis lesions was then examined.ResultsOverall, coronary lesion was observed in the left anterior descending coronary artery (LAD) in 56% patients, whereas 28% and 22% were in the right coronary artery (RCA) and left circumflex coronary artery (LCX), respectively. LAD was most affected and observed in 57% patients with stage 1 CKD. RCA was second-most affected, at 26% CKD stage 1, but it increased to 31%, 38%, and 59% in CKD 3, 4, and 5, respectively. In CKD 5 patients, the RCA was the most affected artery (59%), with 41% LAD lesions. Logistic regression analysis after propensity score matching showed that the odds ratios for an RCA lesion was 3.658 in CKD 5 (p = .025) compared with CKD 1 after adjusting for traditional risk factors.ConclusionThe prevalence of RCA lesions, but not LAD or LCX lesions, increased with increasing CKD stage. The pathophysiology of coronary atherosclerosis may differ by lesion location. Deterioration of renal function may affect progression of atherosclerosis more in the RCA than in the LAD or LCX.     

液相连续反应釜反应效果预测

液相连续反应釜反应效果可如下进行预测。通过实验室装置测定并绘制拟定条件下的反应动力学曲线。把生产釜模拟为带死角和短路的理想釜,用水作介质在生产釜中进行流动模型试验,测量一系列停留时间分布密度函数,得到两个模型参数,并建立操作线方程。反应动力学曲线和操作线的交点为此液相连续反应釜的预测结果。     

载顺铂磁性纳米药物在小鼠体内的组织分布

 目的 研究海藻酸钠改性载顺铂磁性纳米药物的组织分布特征。方法 昆明小鼠84只,随机分为实验组和对照组,分别按顺铂剂量10 mg·kg-1从尾静脉推注载顺铂磁性纳米药物或顺铂0.2 mL,于给药后1,2,4,10 h,1,3,7 d,分7个时间点各处死实验组和对照组一组小鼠（6只）,取出小鼠的心、肝、脾、肺、肾组织,经强酸湿法消化后在原子吸收光谱仪上测定各组织样本中铂的浓度。结果 给药后7个不同时间点磁性顺铂在各组织中的浓度均明显高于顺铂（P<0.001）,7 d后实验组中肝、脾、肾组织中磁性顺铂的浓度分别为（8.31±1.92 ）、（24.23±6.02）、（3.02±0.74） μg·g-1,而对照组中顺铂分别只有（1.47±0.64）、0、（1.62±0.38） μg·g-1。结论 一次性给药后海藻酸钠改性载顺铂磁性纳米药物在小鼠体内的分布与顺铂不同,前者主要分布于肝、脾,并在组织中维持较长时间,后者主要分布于肝、肾,较快从组织中被清除。