全文获取类型
收费全文 | 12561篇 |
免费 | 570篇 |
国内免费 | 186篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 288篇 |
妇产科学 | 590篇 |
基础医学 | 396篇 |
口腔科学 | 78篇 |
临床医学 | 3413篇 |
内科学 | 757篇 |
皮肤病学 | 191篇 |
神经病学 | 234篇 |
特种医学 | 286篇 |
外国民族医学 | 1篇 |
外科学 | 907篇 |
综合类 | 1811篇 |
现状与发展 | 2篇 |
预防医学 | 1778篇 |
眼科学 | 36篇 |
药学 | 1238篇 |
11篇 | |
中国医学 | 1183篇 |
肿瘤学 | 88篇 |
出版年
2024年 | 11篇 |
2023年 | 248篇 |
2022年 | 417篇 |
2021年 | 583篇 |
2020年 | 572篇 |
2019年 | 658篇 |
2018年 | 646篇 |
2017年 | 516篇 |
2016年 | 403篇 |
2015年 | 391篇 |
2014年 | 1027篇 |
2013年 | 1047篇 |
2012年 | 877篇 |
2011年 | 957篇 |
2010年 | 787篇 |
2009年 | 602篇 |
2008年 | 555篇 |
2007年 | 532篇 |
2006年 | 506篇 |
2005年 | 330篇 |
2004年 | 314篇 |
2003年 | 231篇 |
2002年 | 176篇 |
2001年 | 122篇 |
2000年 | 125篇 |
1999年 | 107篇 |
1998年 | 88篇 |
1997年 | 61篇 |
1996年 | 50篇 |
1995年 | 35篇 |
1994年 | 42篇 |
1993年 | 23篇 |
1992年 | 20篇 |
1991年 | 21篇 |
1990年 | 27篇 |
1989年 | 17篇 |
1988年 | 14篇 |
1987年 | 18篇 |
1986年 | 7篇 |
1985年 | 33篇 |
1984年 | 34篇 |
1983年 | 23篇 |
1982年 | 15篇 |
1981年 | 12篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 3篇 |
1975年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
应用计算机网络系统提高门急诊管理水平 总被引:3,自引:0,他引:3
作者介绍的门急诊计算机管理网络系统,应用软件使用FOXPRO2.5FORDOS语言,在两台网络服务器之间应用镜像技术,门诊号的录入使用光笔和条形码技术,实行划价、收费一体化,采用星型拓扑网络结构,保证了网络的先进性、安全性、稳定性和可扩充性。网络系统实现挂号、划价收费、调剂、药品使用管理、工作量统计及经济核算的全程闭环管理格局,有效地堵塞了管理和经济上的漏洞,提高了工作效率和管理水平。该系统已正常运行了12个月,并通过省级科技成果鉴定。 相似文献
62.
为探讨新婚前后人群对避孕方法(特别是紧急避孕方法)的知识、态度和使用以及新婚前后人群对紧急避孕的需求及对推广EC的意愿的建议。采用描述性流行病学研究方法,以郑州市新婚学校为研究现场,直接收集第一手数据。采用EPI INF6.04软件包,和SPSS7.5 FOR WINDOW95软件包,进行数据处理、统计与分析。统计分析的主要指标有:频数分布,单因素分析,logistic多元回归分析等。结果平均年龄26.41岁,女性占49.4%。在第一次同房时,仅有46.4%的人使用过避孕方法。第一次同房时最常用的避孕方法是避孕套(76.1%)。在女性应答者中,25岁以下开始同房者占76.6%,有9.3%的人有过人工流产史。88.2%的人每周有1~6次同房。有43.2%的人听说过EC方法,有35.9%的人听说过紧急避孕片,有29.9%的人知道使用EC片有时间限制,有24.7%的人听说过上环可作为紧急避孕方法,有17.4%的人知道上环紧急避孕方法有时间限制。仅有12.9%的人使用过某种事后避孕方法,其中有事后3天内使用者占82.0%。92.6%的人赞成开展EC教育。73.7%的人认为,应在未婚青少年中开展EC教育。80.7%的人认为,在本单位进行EC教育是可行的。应答者认为,最易的接受的EC教育形式依次为:阅读材料(40.4%),录相(20.6%)和讲课(15.7%)。认为EC的最可靠的信息来源 相似文献
63.
The aim of this study was to estimate the incidence of morbidity and mortality due to injuries in the population over the age of 14 years in Barcelona, Spain. Injury distribution according to sex, age, external cause, place of occurrence of the injury and severity was also obtained. A one-year survey was conducted in the emergency departments of the six main hospitals in Barcelona, based on a multistage sampling. Information was collected prospectively in emergency services by specially trained non-staff interviewers. Mortality data were drawn from death certificates. The incidence rate was 74.7 injury cases per 1,000 person-years over 14 years of age, higher in males than in females. Injury rates were highest in the youngest age-group and progressively lower until people over 75 years of age. Main external causes of injury were falls, being struck or caught by objects, and traffic-related injuries. The leading specific causes of injury mortality were traffic injuries, suicides and poisonings. While the overall admission incidence was 3.34 cases per 1,000 inhabitants, the proportion of hospitalized cases was 45.0 per 1,000 injury cases admitted to emergency rooms, higher for females, for traffic injuries and in the elderly population. Ninety-six percent of injury cases had an ISS value of 8 or less, mean ISS being highest for traffic injuries and falls. Injury morbidity and mortality amongst residents of Barcelona follow sex, age and cause of injury patterns which are, overall, comparable to those observed in other industrialized countries, suggesting that similar etiologic factors might be operating in those areas. The results should enable the orientation of injury prevention policies in the urban environment targeted on the young and the elderly population. 相似文献
64.
Chien Yie W. Chien Te-yen Bagdon Robert E. Huang Yih C. Bierman Robert H. 《Pharmaceutical research》1989,6(12):1000-1010
Several transdermal contraceptive device (TCD) formulations were developed to provide a dual-controlled transdermal delivery of levonorgestrel (LN), a potent progestin, and 17-estradiol (E2), a natural estrogen. Using a sensitive HPLC method, the in vitro release and skin permeation profiles of LN and E2 from various TCD formulations were simultaneously characterized in the hydrodynamically well-calibrated Valia–Chien skin permeation cells and both were found to follow zero-order kinetics. The rates of drug release and skin permeation were observed to vary significantly depending upon some formulation parameters. Six-month stability studies were performed on seven formulations at room and elevated temperatures (37 and 45°C), and two (Formulations 4 and 5) were found to be acceptable, based on drug recovery, release rate, and skin permeation rate data. Judging from the 6-month accelerated stability studies, it is projected these two formulations will have shelf-life of at least 2 years. As a result of development of an efficient manufacturing process, Formulation 4 was selected for further evaluation. One-week primary skin irritation evaluation in 6 rabbits indicated that Formulation 4 is nonirritating, and it was thus selected for Phase I clinical bioavailability/dose proportionality studies in 12 healthy female volunteers of child-bearing age. Results of pharmacokinetic and pharmacodynamic analyses demonstrated that it is capable of achieving and maintaining a steady-state serum level of LN throughout the 3-week treatment period by weekly applications of one or two TCD patches (10 or 20 cm2). A dose proportionality was obtained in the serum drug levels, daily dose delivered, and contraception efficacy. An excellent correlation was obtained for the rates of transdermal delivery determined by the in vitro studies using human cadaver skin, the in vivo studies in rabbits, and the clinical studies in living subjects. 相似文献
65.
Alberto Utrero-Rico Javier Ruiz-Hornillos Cecilia González-Cuadrado Claudia Geraldine Rita Berta Almoguera Pablo Minguez Antonio Herrero-González Mario Fernández-Ruiz Octavio Carretero Juan Carlos Taracido-Fernández Rosario López-Rodriguez Marta Corton José María Aguado Luisa María Villar Carmen Ayuso-García Estela Paz-Artal Rocio Laguna-Goya 《The Journal of allergy and clinical immunology》2021,147(5):1652-1661.e1
66.
Many women find the idea of a once-a-month contraceptive pill an attractive concept. Mifepristone has been shown to be effective as a contraceptive if administered in the early luteal phase. We tested the contraceptive efficacy of 200 mg of mifepristone on day luteinizing hormone (LH) + 2 in a group of 32 women who used a fertility monitor to identify the LH surge. We also recruited a control group, comprising 20 women who were trying to conceive. In this group, 12 women conceived during a total of 50 control cycles (probability of pregnancy 0.25-0.32). Women in the treatment group contributed to a total of 178 cycles and there were two pregnancies (probability of pregnancy 0.01). An LH surge was not detected in 34 cycles (19.1%). In 20 cycles (11.2%) this was due to imperfect use while 14 were monitor method failures (7.9%). Treatment with mifepristone in the early luteal phase did not disrupt the cycle length but women reported slight vaginal bleeding in 15% of the cycles. The combination of a home-use fertility monitor with once-a-month administration of mifepristone (especially if mifepristone is administered at the early luteal phase) is an acceptable contraceptive option with minimal side effects. Unfortunately, it is difficult to envisage how an easier way of defining the correct timing, which required less compliance, could be devised. 相似文献
67.
目的:观察高血压急诊快速降血压对大脑功能的影响情况。方法:监测56例病人含服 降压药前后的脑电活动和血压情况,并对所获资料进行分析。结果:2 h内收缩压(SBP)下降>5.33 kPa (40 mmHg)或舒张压(DBP)下降>4.00 kPa(30 mmHg)时,脑电图异常程度增加,θ及δ频段功率值明 显升高(P<0.01)。结论:降压急骤,可能会造成大脑功能损害 相似文献
68.
Oddsson K Leifels-Fischer B Wiel-Masson D de Melo NR Benedetto C Verhoeven CH Dieben TO 《Human reproduction (Oxford, England)》2005,20(2):557-562
BACKGROUND: This trial was conducted to compare cycle control with vaginal ring a combined contraceptive vaginal ring, and a combined oral contraceptive (COC) delivering 30 mug ethinylestradiol (EE) and 150 mug levonorgestrel. METHODS: This open-label, randomized, multi-centre, Phase III study involved adult women from 11 countries. Subjects were treated with either vaginal ring or a COC for 13 cycles (12 months). RESULTS: A total of 1030 subjects (vaginal ring, n=512; COC, n=518) comprised the intention-to-treat (ITT) population. The percentage of women in the ITT population who completed the trial was 70.9% for vaginal ring and 71.2% for the COC group. The incidence of breakthrough bleeding and spotting over cycles 2-13, the primary efficacy parameter, was lower with vaginal ring (range 2.0-6.4%) than the COC (range 3.5-12.6%), and for cycles 2 and 9 the lower incidence with vaginal ring was confirmed as statistically significant (P=0.003 and P=0.002 respectively). The incidence of intended bleeding was significantly higher over all cycles with vaginal ring (58.8-72.8%) than with the COC (43.4-57.9%). CONCLUSIONS: Cycle control with vaginal ring was excellent and superior to that of a COC containing 30 mug EE. 相似文献
69.
Carlos Guillen-Astete Iria Miguens-Blanco Miguel Zamorano-Serrano Elena Machin-Muñoz Paloma Gallego-Rodríguez Cristina de-la-Casa-Resino 《Educación Médica》2019
Introduction
The care activity of internal resident doctors is common to practically all medical and surgical training programs; however, there are no national data available regarding the situation of this activity from the perspective of the resident. The present study has sought to collect the opinion of the resident internal physicians on the health care performance and the teaching character that links them to their corresponding emergency departments, in the following areas: overall training value, appreciation of the workload, characteristics of the morning rotation, supervision or tutoring, etc.Method
The study was performed using a questionnaire that was distributed at the national level through the network of representatives of the SEMES-MIR group of the Spanish Society of Emergency and Emergency Medicine.Results
A total of 1083 questionnaires were collected from 38 hospitals, corresponding to a response rate of 28%. The most significant educational contribution was the general knowledge about emergency medical care and the interpretation of complementary tests, while the less significant were aspects related to pharmacoeconomics, sustainability and cost-benefit of medical and non-medical processes related to medicine Emergency. As for the burden of care during a day of continuous care, the first year residents saw a mean of 12.3 patients) (SD 2.2), the second and third year 18.1 (SD 2.2), and the older residents 14.5 (SD 2.4). Less than half (44%) of the respondents identified their supervision model as «direct», while 37.2% identified it as «semi-pyramidal». A minority (14.2%) of respondents acknowledged having been encouraged to undertake scientific activities related to emergency medicine.Conclusions
The results of this questionnaire should serve as a basis for the future planning of new models of teaching and care for residents and emergency services, as well as to stratify the priorities of attention to the relationship between emergency services and resident physicians. 相似文献70.
de Vries E den Tonkelaar I van Noord PA van der Schouw YT te Velde ER Peeters PH 《Human reproduction (Oxford, England)》2001,16(8):1657-1662
BACKGROUND: We investigated the hypothesis that long-term use of oral contraceptives (OCs), in particular high-dose OCs, could postpone age at menopause. METHODS: Data was used from 8701 women who participated in a breast cancer screening programme in Utrecht (DOM-3 cohort), and who did not use hormone replacement therapy (HRT) or OCs in the 4 years prior to their last menses. Data on OC-use, menopausal status, age at menopause, year of birth, parity, smoking behaviour, socio-economic status, body mass index and age at menarche was available. Use of high-dose OCs has been defined in this study as OC-use before 1972. The data was analysed by means of linear regression and Cox's proportional hazards analysis. Women still menstruating, women with surgical menopause and women lost to follow-up were censored at their last known date of menstruation. Endpoint was the natural menopause (n = 4589). RESULTS: The use of high-dose OCs advanced the onset of menopause by approximately 1.2 months for every year of OC-use compared with no OC-use. High-dose OC-use for > or = 3 years, adjusted for confounding variables, increased the risk of earlier menopause compared with no OC-use (adjusted hazard ratio 1.12; 95% CI 1.03--1.21). The use of lower dose OCs did not increase the risk of earlier menopause (adjusted hazard ratio 1.00; 95% CI 0.91--1.09). CONCLUSIONS: These results are inconsistent with the hypothesis that long-term use of OCs could postpone the onset of menopause by inhibiting follicle depletion. Possible explanations are discussed. 相似文献