喉咽清水蜜丸的研制及其药效学和毒理学研究

目的 :研究喉咽清水蜜丸的制备、质量控制方法及其药效学和毒理学。方法 :采用高效液相色谱法测定喉咽清水蜜丸中甘草酸的含量 ;对制剂的抗炎、镇痛、祛痰作用进行研究 ;对制剂的急性毒性和长期毒性进行研究。结果 :喉咽清水蜜丸中甘草酸的线性范围为0 0384～0 615mg/ml ,回收率为 (99 20±1 75) %。本制剂具有抗炎、镇痛、祛痰作用 ,未见明显急性毒性和长期毒性。结论 :本制剂制备工艺简单 ,质量可控 ,疗效确切 ,安全性较高。     

常用口服雌激素避孕药制剂的含量均匀度考察

目的　建立口服避孕制剂含量均匀度的检查法 ,考察中国常用口服雌激素避孕药制剂的内在质量。方法　以十八烷基硅烷键合硅胶为填充剂 ,以不同比例乙腈 -水为流动相 ,检测波长 2 2 0nm。结果　所测定的 3批样品 6个品种中 ,除复方炔诺孕酮薄膜衣片和左炔诺酮片含量均匀度符合规定外 ,其余含量均匀度未达到药典要求 (A +1 8s >15 )。结论　首次采用HPLC方法对我国女性常用的避孕制剂的含量均匀度进行考察 ,测定结果不尽人意。为确保避孕药使用的安全有效 ,需要尽快制定避孕制剂的含量均匀度的检查要求。     

正交试验法优选失笑滴丸的滴制工艺

 目的:采用正交试验法对失笑滴丸的滴制工艺进行优选试验。方法:选择药液温度、滴头口径、药物与基质的配比、浦速等4因素，每个因素各取3个水平，按L₉(3)⁴正交表安排实验，用3个指标评定工艺的优劣。结果:采用药液温度为95℃,滴头口径内径为3.3 mm、外径为5.2 mm，药物与基质的配比为3.5:6.5,以40滴· min^-1的滴速滴入甲基硅油中的工艺条件最佳。结论:用正交试验法优选失笑滴丸的滴制工艺是可行的。     

Parity and other reproductive factors and risk of adenomatous polyps of the distal colorectum (United States)

Evidence for an effect of reproductive factors on colorectal carcinogenesis is inconsistent and little is known about their role in development of precursor adenomatous polyps. We evaluated the relation between reproductive factors and distal colorectal adenomas (n = 982) during14 years of follow up of 26,983 participants in the Nurses' Health Study(United States). The women were free of diagnosed cancer or polyps in 1980,underwent endoscopy 1980-94, and had reported on their parity, oral contraceptive (OC) use, and ages at menarche, first term-pregnancy, and menopause. We calculated relative risks (RR) and 95 percent confidence intervals (CI) using multiple logistic regression. Women with higher parity had an increased risk of adenomas of the distal colorectum (P trend = 0.004;6+ cf 0 parity: RR = 1.3, CI = 0.9-1.8) or distal colon (P trend = 0.002, RR= 1.7, CI = 1.2-2.6). This association was significantly stronger among women with a family history of colorectal cancer ( P interaction = 0.03); comparing6+ term-pregnancies with nulliparity, among those with a family history, the RR for distal colon adenoma was 3.2 (CI = 1.4-7.2), while among those without a family history, the RR was 1.3 (CI = 0.8-2.2). We observed no association for distal colorectal adenoma and age at menarche, age at first term-pregnancy, ever use of OCs, or menopausal status. Further work is needed to clarify the relation of parity with colon adenoma risk. This revised version was published online in July 2006 with corrections to the Cover Date.     

御感速袋泡剂质量标准的研究

御感速袋泡剂按新药审评标准进行了质量标准的研究，鉴别项下除建立了显微方法外还建立了柴胡皂甙ａ，ｄ，连翘甙，葛根素，青蒿的薄层鉴别方法。用ＨＰＬＣ对黄芩甙和葛根素进行了含量测定。     

绞股蓝总甙复合国产1号避孕片对健康妇女脂类代谢及血压的影响

本研究将180名已婚、一孩、年龄33±5岁,需要使用避孕措施的健康妇女随机分成6组,即IUD组、绞股蓝总甙加IUD组、1号OC片组、40mg、60mg、80mg绞股蓝总甙分别与1号OC片复合的3个试验组.用双盲法给药,连续服用6个月观察脂类代谢和血压的变化.结果显示:以IUD组和1号OC片组的数据为参比值.服用不同剂量绞股蓝总甙复合口服避孕药后无升高TG和TC的趋势,有显著升高HDL-C作用和使APOA_1水平上升的趋势;亦存在降低收缩压的趋势,对舒张压无明显影响,但在服药后3个月时HDL-C水平曾发生暂时性下降.     

内障丸防治D-半乳糖白内障的实验研究

目的:观察中药内障丸对D-半乳糖性白内障的防治作用。方法:将60只3～4周龄SD大鼠分为5组,分别用蒸馏水、维生素E生理盐水混悬液及中、高剂量内障丸水煎剂灌胃,对照观察注射55%D-半乳糖后大鼠晶状体混浊的发生时间与程度,血清及晶状体SOD、MDA含量。结果:中药组及维生素E组大鼠的白内障发生发展速度较模型组缓慢(P<0.05),各观察组与对照组血清及晶状体的SOD、MDA含量比较有统计学意义(P<0.05)。结论:内障丸通过改善大鼠体内的抗氧化系统功能,能够延缓大鼠D-半乳糖性白内障的发生和减轻其白内障发展程度。     

二十五味鬼臼丸联合微波等治疗盆腔积液疗效观察

Objective To observe clinical effect of treating pelvic effusion with twenty five tastes podophyllum pill combined with antibiotics, microwave. Methods 182 cases patients with inflammatory pelvic effusion were randomly divided into two groups. The treatment group was treated with twenty five tastes podophyllum pill combined with antibiotics、microwave, and the control group was treated with antibiotics combined with microwave. The absorption, symptoms disappeared and cure situations of pelvic effusion were observed between control group and treatment group after treatment.Results The complete absorption, symptoms disappeared and cure situations of pelvic effusion in the treatment group was significantly higher than that of the control. The total effective rate of the treatment group was 100%, and the total effective rate of the control group was 87.5%, which has a significant difference (P<0.05) .Conclusion The treatment of twenty five tastes podophyllum pill combined with antibiotics, microwave on pelvic effusion is better than western medicine.     

乡镇医院在卫生突发事件中作用的调查

目的评估我省乡镇医院应对卫生突发事件应急能力.方法信访128个县市疾病控制中心负责人和部分乡镇医院负责人,调查内容包括卫生突发事件发生时乡镇医院的定位,应具备的设备、人员配备和经费支持等.结果绝大多数县市疾病控制中心负责人肯定乡镇医院为卫生应急系统的主要组成部分.乡镇医院负责人都认为乡镇医院是应急体系的必须部分,但目前状况不能适应需要,需要投资建设.结论政府应充分重视乡镇医院在卫生突发事件应急体系中的作用和建设.     

影响急诊满意度因素分析

目的了解急诊患者满意度的影响因素.方法通过问卷方式对急诊患者满意度进行调查,并予统计描述及回归分析,建立数学模型.结果满意度与患者是否再就诊、医务人员是否告诉患者等待时间、是否给予帮助、是否告诉返回复诊时间、是否对疾病已经解释清楚、是否解释化验结果、是否告诉正常生活时间等有相关性.结论患者满意度与多个因素有关,急诊医护人员应加强服务方式的培训.