肠道菌群与脓毒症相互关系的研究进展

脓毒症的发生发展与肠道菌群失调密切相关.肠道菌群失调可以通过肠黏膜屏障功能破坏、黏膜免疫功能破坏和细菌移位等环节诱导脓毒症的发生.同时脓毒症也可以加重肠道菌群失调,加重肠黏膜屏障功能破坏,导致机体多器官功能障碍.本文通过探讨肠道菌群和脓毒症之间的相互关系,为脓毒症临床干预提供思路.     

Comprehensive treatment of temporomandibular joint disorders

Aims:

Changing lifestyles, decreasing physical activity, which is increasing the number of degenerative joint diseases of various etiology, and certain dental procedures are increasing the number of patients complaining of pain in their temporomandibular joints. The aim of the study was to assess the benefits of comprehensive physiotherapy sessions in order to decrease the number of temporomandibular joint problems, thereby improving the patient’s quality of life.

Methodology:

An examination by a dentist determined each patient’s treatment plan, which consisted of a medical exam, physical therapy and education. Each form of treatment was applied 10 times at intervals of 7–14 days. The main goal of the therapeutic physical education was to redress the muscle imbalance in the mandibular joint. This was achieved by restoring balance between the masticatory muscles, along with releasing the spastic shrouds found in the masticatory muscles. The aim of education was to teach the patient exercises focused on the temporomandibular joint and masticatory muscles. The intensity of the exercises and their composition were individually adjusted and adapted to their current state. Physical therapy consisted of the application of pulsed magnetic therapy, laser therapy, and non-invasive positive thermotherapy.

Results:

The above procedure was conducted on a therapeutic group of 24 patients (3 men and 20 women). In the course of therapy, there were no complications, and all patients adhered to the prescribed regime. None reported any side effects. The mean treatment duration was 123±66 days. The outcome of the therapy was evaluated as described in the methodology, the degree of pain affecting the joint, and the opening ability of the mouth. In both parameters, there was a significant decline in patient pain.

Conclusions:

In a study devoted to tactics of rehabilitation treatment for temporomandibular joint disorders, the need for comprehensive long-term therapy, involving education, and learning proper chewing habits was made apparent for recovery and pain reduction. A priority in physical therapy, and combinations of pulsed magnetic therapy and hyperthermia-positive peloids, are also beneficial.     

公益性回归遭遇价值失衡

医护人员劳动价值贬低是影响医院公益性回归不可忽视的条件，本文在分析价值失衡制约公立医院公益性质的基础上，提出适当提高医护人员技术含量较高的医疗服务项目收费价格的必要性。     

Kinetic asymmetries during running in male youth

ObjectivesA possible injury risk factor is limb asymmetry, which may differ across maturation given the adult growth spurt. The aim of this study is to quantify the magnitude of asymmetry in a number of kinetic variables during a running task in male youth of different maturity status.DesignQuantitative observational laboratory study.SettingSports performance laboratory.ParticipantsNon-injured youth athletes in pre-, mid-, and post-pubescent status.Main outcome measuresInter-limb leg asymmetries whilst sprinting on a non-motorized treadmill. Percent asymmetry was defined as: (Left leg − right leg)/right leg*100 = %asymmetry.ResultsHorizontal force presented limb asymmetries of 15.4, 14.8 and 14.7% for the pre-, mid- and post-PHV group respectively. Values for vertical force were higher (18.1, 20.2 and 20.8% respectively). Power asymmetries were 14.9, 15.8, and 15.5% respectively and work asymmetries were significant higher in pre-PHV participants (26.4%) compared to mid- (14.7%) and post-PHV (17.3%) participants.ConclusionsAs the population in this study was characterized as non-injured, asymmetries of 15–20% appeared typical during a running task in developmental athletes.     

600例体检妇女阴道微生态环境与年龄关系的分析

目的:分析不同年龄体检妇女阴道微生态环境变化规律。方法:对在深圳宝安区人民医院体检中心进行健康体检的600例妇女阴道分泌物进行微生态检测,检测指标包括清洁度、念珠菌、滴虫、阴道酸碱度(PH值)、唾液酸苷酶、白细胞酯酶、过氧化氢(H2O2)浓度。结果:19～50岁范围内各年龄组阴道微生态指标pH>4.5、唾液酸苷酶、白细胞酯酶及阴道清洁度(Ⅲ～Ⅳ°)阳性率随年龄增长逐渐上升,差异有统计学意义(P<0.05),>50岁上述指标呈下降趋势,与上述各组比较差异有统计学意义(P<0.05);念珠菌检出率亦随年龄增长呈下降趋势,但各组间差异无统计学意义(P>0.05)。结论:深圳市宝安区体检妇女阴道微生态环境与年龄呈正态分布,即31～50岁阴道微生态失调率明显高于19～30岁及>60岁组,差异有统计学意义(P<0.05)。     

2003-2013年甘肃省科技奖医药卫生获奖成果分析

分析2003-2013年11年甘肃省科技奖医药卫生获奖成果,找出甘肃医药卫生研究的发展趋势和部分研究机构、研究团队、学科在科技研究中的引领作用,同时认识到该领域研究存在的机构和地区发展的不平衡性.     

香青兰总黄酮对支气管哮喘大鼠Th1/Th2免疫失衡的调节作用

 目的观察香青兰总黄酮对支气管哮喘大鼠辅助T淋巴细胞1（Th1）/辅助T淋巴细胞2（Th2）细胞因子失衡的调节作用。方法采用卵白蛋白致敏和激发建立大鼠哮喘模型,给予香青兰总黄酮进行干预后,ELISA法检测大鼠支气管肺泡灌流液中白介素4（IL-4）、干扰素γ（IFN-γ）及嗜酸粒细胞趋化蛋白1（Eotaxin-1）的水平。结果香青兰总黄酮可剂量依赖性的降低哮喘大鼠支气管肺泡灌流液中IL-4和Eotaxin-1含量,升高IFN-γ含量,减小IL-4/IFN-γ比值（P<0.05或0.01）。结论香青兰总黄酮对支气管哮喘Th1/Th2免疫失衡有一定调节作用。     

5·12汶川大地震挤压综合征伤员电解质紊乱特点分析

目的 探讨汶川地震挤压综合征伤员电解质紊乱的特点.方法 对149例地震挤压综合征伤员的临床特点,尤其是电解质紊乱的特点进行分析.结果 与非挤压综合征伤员比较,149例(8.2%)挤压综合征伤员有更严重的肾功能损害,血钾及血磷水平更高,血钙水平更低(P＜0.05);同时表现出血清天冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)和肌酸激酶(CK)水平显著升高(P＜0.05);电解质紊乱表现多种多样,包括高钾血症、低钾血症、低钠血症、低钙血症、高磷血症、低磷血症以及代谢性酸中毒,尤其是高钾血症,不但严重而且顽固,需要尽早积极治疗.结论 地震后挤压综合征伤员表现出严重而且复杂的电解质紊乱,高钾血症是最严重的表现,需要密切监测和积极治疗.     

性别比平衡失衡与复衡

性别比平衡是生物界中有性生殖的重要条件,各物种(包括人类)的性别比是通过自然选择逐渐形成的。人口性别比平衡是社会发展的稳定因素,由于重男轻女而人为地出生性别比过高,导致性别比失衡,进而使某些职业出现性别结构性缺员、婚姻挤压、失婚、婚外恋、买卖婚姻、卖淫嫖娼等社会弊病严重,而其根本原因在于历史传统和现实社会的经济、文化、道德、习俗、法律等因素形成的男尊女卑的价值取向。我们的出路只能是在科学发展观指导下,发展经济、健全法制、完善社会保障、强化男女平等的宣传教育,标本兼治,恢复人口性别比平衡。