Surveillance interval of endoscopic examinations for colorectal cancer screening

Background: There have been a few evidence‐based studies concerning the relationship between the length of the surveillance interval of colonoscopic examinations and the risk of colorectal cancer (CRC). The aim of the present study was to assess the appropriate interval between endoscopic examinations for CRC screening in a retrospective cohort study. Methods: The cohort included subjects in whom cancer was not detected at the initial endoscopic examination and in whom endoscopic examination(s) was subsequently performed one or more times. The results of the endoscopic examinations performed in the mass screening for CRC between November 1983 and March 1999 were analyzed. The study end point was the detection of CRC and the detection rates of cancer were assessed among those who underwent examinations at various intervals between successive endoscopic examinations. Results: Among the 117 636 cohort subjects, 63 invasive cancer cases and 112 mucosal cancer cases were found. The odds ratio (OR) for invasive cancer was not significantly elevated even when the interval between successive examinations was over 5 years. The OR for mucosal or invasive cancer was significantly elevated among the subjects in whom the interval between successive examinations was over 5 years (OR, 1.71; 95% confidence interval (CI), 1.07–2.73), than among those in whom the interval was 1 year. Conclusions: Since prolongation of the interval between endoscopic examinations of up to 5 years did not result in any change in the cancer risk among persons who are at average risk for CRC, 5 years may be an adequate interval between endoscopic examinations in the mass screening for CRC.     

车间金属汞卫生标准的研究

本文报道了四个地区五个工厂(1979～1988年)汞作业点18539次汞蒸气浓度的测定,和227名连续接汞十年的工人进行动态健康监护的结果,证实汞接触水平与尿汞量之间,以及神衰症侯群、汞毒性细小震颤、口腔炎和精神症状与汞接触水平之间均存在剂量反应关系。汞接触十年,当接触水平低于0.01mg/m~3时,无中毒病例发生;接触水平≤0.03mg/m~3,汞中毒为1.9%,神衰症侯群为22.2%,震颤为3.7%,口腔炎为9.3%;接触水平≤).06mg/m~3,汞中毒为17.4%,神衰症侯群,口腔炎和震颤各为39.1%、21.7%和15.2%。根据我国现有防汞技术设施水平,结合国情,以保护接触汞的95%人群不发生中毒,建议汞的卫生标准由原0.01mg/m~3修订为0.03mg/m~3。     

膀胱癌患者外周血树突状细胞免疫状态变化及其临床意义

目的探讨膀胱癌患者外周血中树突状细胞（DC）的免疫功能状态变化及其与膀胱癌发生的关系。方法检测15例临床确诊的中晚期膀胱癌患者外周血DC表面CD1a、CD83表达水平及免疫诱导T淋巴细胞增殖的能力，并与10名健康成人比较。结果膀胱癌患者DC表面CDla及CD83表达水平（分别为57．4±1．6，72．1±1．1）明显低于正常对照组（64．9±1．4，80．6±1．2，P〈0．05）；其体外诱导T细胞增殖的能力亦明显低于正常对照组（P〈0．05）。结论膀胱癌患者DC存在免疫功能缺陷可能是膀胱癌逃避宿主免疫监视的重要原因之一。     

实验性硅沉着病大鼠血清铜蓝蛋白活性动态观察

目的　观察硅沉着病病变过程中血清铜蓝蛋白 (ceruloplasm in,Cp)的动态变化。方法　通过建立大鼠硅沉着病模型 ,并分别于早期和病后给药治疗 ,测定不同时期血清 Cp活性。结果　血清 Cp活性随病变进展而增高 ,病后治疗到 180 d与开始给药时相近 ,预防治疗组染尘后前 6 0 d升高 ,原因有待研究 ;鼠龄与体重对其未见相关影响。结论　各期硅沉着病血清 Cp含量与病情进展有平行趋向     

Delphi在24小时动态心电监护系统软件分析中的应用

在回放式２４ｈ 动态心电监护系统中，需要对大量的数据进行处理和分析，从而实现对心电信号的检测，分类，心律失常分析，心律变异分析，报表打印功能。本文介绍了利用面向对象的Ｄｅｌｐｈｉ 开发工具和其内置数据库引擎（ＢＤＥ） 来实现上述功能，并介绍了利用Ｄｅｌｐｈｉ 来进行心电信号波形浏览控件研制，使之可成为生物医学虚拟仪器中的医学信号波形浏览控件。     

Acceptability of Internet adverse event self-reporting for pandemic and seasonal influenza immunization among health care workers

This study assessed the acceptability and feasibility of Internet self-reporting for adverse events following pandemic and seasonal influenza immunization among 270 health care workers at a tertiary care children's and women's hospital in fall 2009. Participants responded to an online questionnaire 72 h after vaccine receipt. Non-responders were sent a reminder email 8–10 days after vaccine receipt, followed by a telephone call for those who did not respond online. The overall online response rate was high (88%). Participants rated the online self-report easy to use and would be willing to use it again. The high response rate and acceptability of the online report method suggest that web-based self-reporting for adverse event following immunization (AEFI) has the potential for rapid assessments of AEFI in mass or new immunization programs.