全文获取类型
收费全文 | 38898篇 |
免费 | 2596篇 |
国内免费 | 550篇 |
专业分类
耳鼻咽喉 | 227篇 |
儿科学 | 1503篇 |
妇产科学 | 410篇 |
基础医学 | 5936篇 |
口腔科学 | 213篇 |
临床医学 | 2795篇 |
内科学 | 3804篇 |
皮肤病学 | 2060篇 |
神经病学 | 1105篇 |
特种医学 | 455篇 |
外科学 | 1530篇 |
综合类 | 3845篇 |
预防医学 | 4280篇 |
眼科学 | 231篇 |
药学 | 10773篇 |
13篇 | |
中国医学 | 645篇 |
肿瘤学 | 2219篇 |
出版年
2024年 | 66篇 |
2023年 | 418篇 |
2022年 | 1057篇 |
2021年 | 1402篇 |
2020年 | 1140篇 |
2019年 | 1134篇 |
2018年 | 1140篇 |
2017年 | 1096篇 |
2016年 | 1164篇 |
2015年 | 1313篇 |
2014年 | 2636篇 |
2013年 | 3257篇 |
2012年 | 2557篇 |
2011年 | 2925篇 |
2010年 | 2129篇 |
2009年 | 2065篇 |
2008年 | 2084篇 |
2007年 | 1969篇 |
2006年 | 1638篇 |
2005年 | 1390篇 |
2004年 | 1149篇 |
2003年 | 995篇 |
2002年 | 809篇 |
2001年 | 719篇 |
2000年 | 612篇 |
1999年 | 638篇 |
1998年 | 456篇 |
1997年 | 461篇 |
1996年 | 376篇 |
1995年 | 334篇 |
1994年 | 315篇 |
1993年 | 228篇 |
1992年 | 212篇 |
1991年 | 167篇 |
1990年 | 155篇 |
1989年 | 124篇 |
1988年 | 175篇 |
1987年 | 163篇 |
1986年 | 146篇 |
1985年 | 166篇 |
1984年 | 175篇 |
1983年 | 101篇 |
1982年 | 108篇 |
1981年 | 75篇 |
1980年 | 93篇 |
1979年 | 79篇 |
1978年 | 76篇 |
1977年 | 64篇 |
1976年 | 71篇 |
1975年 | 71篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
31.
32.
含左氧氟沙星及卷曲霉素方案治疗耐多药肺结核近期疗效分析 总被引:21,自引:0,他引:21
目的 观察和评价含左氧氟沙星和卷曲霉素联合化疗方案在耐多药肺结核 (MDR PTB)治疗中的疗效。方法 将 177例MDR PTB患者分为治疗组 88例和对照组 89例。化疗方案 :治疗组以左氧氟沙星和卷曲霉素为主 ,联合利福喷汀、异烟肼、对氨基水杨酸钠、吡嗪酰胺 ;对照组用链霉素、乙胺丁醇 ,联用药物同治疗组 ,疗程均为 2 1个月。结果 共有 16 1例患者完成化疗疗程 ,治疗组 82例 ,痰菌阴转率 83% ;对照组 79例 ,痰菌阴转率 5 8% ;痰菌阴转率治疗组明显高于对照组 (P <0 0 1) ;治疗组病灶显效率 5 0 % ,空洞闭合率 6 3% ,治疗组优于对照组 (P <0 0 1) ;治疗组的药物不良反应率为 31% ,对照组为 35 % ,两组比较差异无显著性 (P >0 0 5 )。结论 含左氧氟沙星和卷曲霉素的方案治疗MDR PTB ,有助于痰菌阴转和病变吸收好转 ,药物不良反应低 ,值得在临床上推广应用 相似文献
33.
34.
James H. McKerrow 《Perspectives in Drug Discovery and Design》1995,2(3):437-444
Summary Papain family cysteine proteases function primarily intracellularly in higher eukaryotes, but are often extracellular proteases in protozoan helminths. The utility of this class of enzymes is reflected in the diversity of functions they perform in both parasite life cycles and the pathogenesis of parasitic diseases. Examples include secretion of proteases into the gut of parasitic worms for hemoglobin degradation, release from the surface of nematodes to degrade cuticular proteins during molting, and facilitating excystment of protozoa. 相似文献
35.
103例角膜溃疡的病因和病原及药物敏感试验的统计分析 总被引:7,自引:0,他引:7
对1995年1—12月间我院门诊103例角膜溃疡的病因、病原和药物敏感试验进行统计分析。病因:外伤59例(57.28%),继发感染34例(33.01%),原因不明8例(7.77%),戴接触镜2例(1.94%)。病原:真菌35例(33.98%),绿脓杆菌18例(17.48%),金黄色葡萄球菌15例(14.56%),表皮葡萄球菌9例(8.74%),淋球菌2例(1.94%)。对19例真菌性角膜溃疡同时进行细菌培养,有7例为混合感染,占36.84%。对几种主要检出菌的药物敏感试验表明:它们对普通抗菌素均可产生一定的耐药性 相似文献
36.
Oral allergy syndrome induced by spinach 总被引:1,自引:1,他引:0
I. Sanchez F. Rodriguez J. L. Garcia-Abujeta L. Fernandez D. Quiñones D. Martin-Gil 《Allergy》1997,52(12):1245-1246
37.
M. Wensing A. H. Penninks† S. L. Hefle‡ J. H. Akkerdaas§ R. van Ree§ S. J. Koppelman† C. A. F. M. Bruijnzeel-Koomen A. C. Knulst 《Clinical and experimental allergy》2002,32(12):1757-1762
BACKGROUND: The risk for allergic reactions depends on the sensitivity of individuals and the quantities of offending food ingested. The sensitivity varies among allergic individuals, as does the threshold dose of a food allergen capable of inducing an allergic reaction. OBJECTIVE: This study aimed at determining the distribution of minimum provoking doses of hazelnut in a hazelnut-allergic population. METHODS: Thirty-one patients with a history of hazelnut-related allergic symptoms, a positive skin prick test to hazelnut and/or an elevated specific IgE level, were included. Double-blind, placebo-controlled food challenges (DBPCFC) were performed with seven increasing doses of dried hazelnut (1 mg to 1 g hazelnut protein) randomly interspersed with seven placebo doses. RESULTS: Twenty-nine patients had a positive challenge. Itching of the oral cavity and/or lips was the first symptom in all cases. Additional gastrointestinal symptoms were reported in five patients and difficulty in swallowing in one patient. Lip swelling was observed in two patients, followed by generalized urticaria in one of these. Threshold doses for eliciting subjective reactions varied from a dose of 1 mg up to 100 mg hazelnut protein (equivalent to 6.4-640 mg hazelnut meal). Extrapolation of the dose-response curve showed that 50% of our hazelnut-allergic population will suffer from an allergic reaction after ingestion of 6 mg (95% CI, 2-11 mg) of hazelnut protein. Objective symptoms were observed in two patients after 1 and 1,000 mg, respectively. CONCLUSION: DBPCFCs demonstrated threshold doses in half of the hazelnut-allergic patients similar to doses previously described to be hidden in consumer products. This stresses the need for careful labelling and strategies to prevent and detect contamination of food products with hazelnut residues. 相似文献
38.
B. Tutluolu S. At A. N. Anakkaya E. Altu G. A. Tosun M. Yaman 《Clinical and experimental allergy》2002,32(8):1170-1173
OBJECTIVE: This study aimed to investigate the rate of occupational sensitization to horse hair in grooms and whether occupational exposure to horse hair increases respiratory and allergic symptoms and affects lung function in grooms or not. METHODS: This is a cross-sectional study. Two hundred grooms were randomly selected among 1000 grooms working in Veliefendi Hippodrome of Istanbul. One hundred and twenty-five subjects agreed to enter the study. Ninety-two workers who worked in the different parts of this hippodrome enrolled as the control group. A detailed questionnaire including respiratory and allergic symptoms was filled in, physical examination, skin prick tests and pulmonary function tests were performed. RESULTS: Sensitization to horse hair was 12.8% in grooms and 4.3% in controls. The difference was statistically significant (P = 0.0035). Asthma was found in 14.4% of the grooms and 5.4% of the controls, allergic rhinitis in 42.4% of the grooms and 18.4% of the controls, allergic conjunctivitis in 35.2% of the grooms and 15.2% of the controls, and allergic skin diseases in 32.8% of the grooms and 13% of the controls. The differences were statistically significant (P = 0.043, P = 0.0002, P = 0.001 and P = 0.0008, respectively). The means of FEV1, FEV1/FVC and FVC parameters were significantly lower in the groom group (P = 0.006, P = 0.001 and P = 0.003, respectively). In the multivariate analysis, being in the groom group and working years were found to be predictive factors for impairments of lung function (P < 0.001 and P = 0.002, respectively). CONCLUSION: Occupational exposure to horse increases the sensitization to horse hair, induces asthma and allergic symptoms and also impairs lung functions. 相似文献
39.
Cocaine-treated rats acquired a preference for cocaine-associated contextual stimuli (CS) relative to saline-injected control rats. However, when animals were given repeated tests for conditioned place preference intermittent between conditioning trials, they displayed an attenuation in strength of conditioning. This attenuation was not due to pharmacologic tolerance (Experiment 1), but rather reflected a disruption in learning due to exposure to the CS alone (Experiment 2). Like other examples of classical conditioning, the strength of the conditioned response (CR) as assessed by the conditioned place preference model may be influenced by partial reinforcement. 相似文献
40.
铁制剂治疗缺铁性贫血的随机对照临床研究 总被引:6,自引:0,他引:6
目的 了解硫酸铁控释片、琥珀酸亚铁、多糖铁复合物治疗缺铁性贫血的疗效及不良反应。方法 将105例不诊于血液科门诊的缺铁性贫血患者,按照入选标准,以随机区组的方法随机分入3个治疗组,分别予以硫酸业铁控释片(福乃得,500mg,每日1次)、琥珀酸业铁(速力菲,,0.1g,每日3次)、多糖铁复合物(力蜚能,0.15g,每日2次)治疗8周,每1-2周随访1次,随访血常规、网织红细胞计数及药物的不良反尖。治疗前及治疗结束检查血清铁、总铁结合力、血清铁蛋白等有关铁参数。结果与结论 以血红蛋白和血清铁蛋白恢复正常作为完全缓解的标准,硫酸亚铁控释片、琥珀酸亚铁、多糖铁复合物3种药治疗8周,缺铁性贫血的完全缓解率分别为74%、76%、40%(P=0.004),总的有效率分别为81%、89%、76%(P>0.05)。主要的不良反应为胃肠道反应,3种药中以多糖铁复合物的不良反应最少,其次为琥珀酸亚铁,硫酸铁控释片的不良反应最常见,但大多数能够耐受。 相似文献