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111.
骨感染病人TNF-α、IL-6和C反应蛋白的检测及临床意义 总被引:1,自引:0,他引:1
①目的 探讨骨感染病人肿瘤坏死因子α(TNF α)、白细胞介素 6 (IL 6 )和C反应蛋白 (CRP)水平的变化及意义。②方法 采用双抗体夹心ELISA法测定 30例骨感染病人及 2 5例正常人的血清TNF α、IL 6水平 ,采用散射比浊法测定CRP水平。③结果 骨感染病人血清中TNF α、IL 6及CRP含量均处于高水平状态 ,与健康人比较 ,差异有显著性 (t=2 .2 6~ 10 .6 7,P <0 .0 5、0 .0 1)。④结论 TNF α、IL 6及CRP是预测骨感染病人病情危重的重要指标之一 ,对临床有一定指导意义 相似文献
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Patrick Terheyden Jürgen C. Becker Christa Lurz George J. Kahaly Eva‐B. Brcker 《Journal der Deutschen Dermatologischen Gesellschaft》2003,1(1):30-35
Background: Scleromyxoedema is a rare disease of unknown aetiology that is characterized by deposition of mucin and sclerotic induration of the skin; it is associated with paraproteinaemia. Patients suffer from progressive disability due to immobilization and cosmetic disfigurement. Treatment of scleromyxoedema is a therapeutic challenge. The antimalarial hydroxychloroquine has a rapid and reliable effect in reticular erythematous mucinosis. Patients and methods: Four consecutive patients (two women, two men; median age: 50 years) with scleromyxoedema, three of them with IgG λ paraprotein, were treated with hydroxychloroquine. Treatment was initiated with 600 mg p. o. for 10 days, followed by 400 mg for at least 4 weeks, and 200 mg thereafter. Results: Complete remission of skin manifestations was achieved in one patient, whereas three patients achieved a partial remission of 61+, 5 and 25 months' duration. Notably, three patients felt increased mobility and reduced firmness of skin during the first week of treatment, which was reflected in a rapid reduction in dermal thickness. In one patient, dysphagia was reverted as evidenced by normalization of oesophageal clearance. Paraproteinaemia was not influenced at all. Side effects included one case of electroretinogram abnormalities after 19 months of therapy and one case of leucopenia after 3 months. Conclusion: Hydroxychloroquine is an effective form of therapy for scleromyxoedema, leading to rapid and prolonged alleviation of symptoms. 相似文献
115.
琼脂糖胶/聚苯乙烯磺酸微囊化胰B细胞株MIN6作为人工生物胰的实验研究 总被引:1,自引:0,他引:1
应用琼脂糖胶/聚苯乙烯磺酸微囊化胰B细胞林MIN6作为人工生物胰进行大鼠皮下异种移植。结果表明,在不应用任何免疫抑制剂的情况下,大鼠皮下异种移植一周后,重新取出的微囊仍保持光滑完整的球状,其内MIN6细胞仍清晰可见,囊周无明显纤维化及粘着。胰岛素释放试验结果显示,低糖浓度刺激时胰岛素的释放量为19.20±1.35μU·10microbead-1/h;高糖浓度刺激时胰岛素的释放量达到51.47±3.80μU·100microbeads-1/h,约为低糖浓度时的2.7倍,与低糖浓度时比较其差异有高度显著性(P<0.001)。提示琼脂糖胶/聚苯乙烯磺酸微囊化胰B细胞林MIN6作为人工生物胰,既能保护移植物膜B细胞株MIN6免受排斥反应,也能维护膝B细胞株MIN6对糖刺激的有效的胰岛素分泌反应性。 相似文献
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Fentanyl and the interleukin-6 response to surgery 总被引:12,自引:0,他引:12
It has been suggested that large doses of opioids may suppress the interleukin-6 response to surgery. We examined the effects of the supplementation of inhalational anaesthesia with either 3 or 15 μg.kg−1 fentanyl on the circulating interleukin-6, interleukin-8, C-reactive protein, cortisol and glucose concentrations in 16 patients undergoing pelvic surgery. In both groups, surgery evoked the expected glucose, cortisol and interleukin-6 response but no increase in interleukin-8 was detected. There were no significant differences between the two groups. We conclude that the supplementation of inhalational anaesthesia with conventional doses of opioids does not modify the cytokine response to surgery. 相似文献
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Soluble CD14 but not interleukin-6 is a new marker for clinical activity in atopic dermatitis 总被引:4,自引:0,他引:4
Summary Levels of soluble IL-2 receptors, IL-6, soluble CD23, soluble CD14 and ECP (eosinophilic cationic protein) were measured as markers of T-cell, B-cell, monocyte and eosinophilic leucocyte activation in 26 patients with atopic dermatitis (AD) on admission to (A) and at discharge from (D) the Department of Dermatology in Zurich. The serum levels of sIL-2R, IL-6, sCD23, sCD14 and ECP were significantly elevated in AD patients in comparison with the normal values of healthy donors. A significant decrease in sIL-2R (p=0.0093) and in sCD14 (p=0.0134) levels was demonstrated between A and D, correlating with the improvement in the skin intensity score (SIS). In addition, a significant correlation of the sCD14 levels and the SIS at A was demonstrated (p=0.0415). These results also incriminate monocytes in the pathogenesis of AD, indicating that, besides sIL-2R and ECP, SCD14 could also be a possible marker for the disease activity. 相似文献
120.
目的研究重庆市新生儿黄疸儿G6PD三种常见基因突变与其临床表现特点之间的关系。初步估计其基因突变频率并探讨其临床意义和遗传学特征。方法应用突变特异性扩增系统(ARMS)法,检测54例重庆市新生儿黄疸儿的G6PD基因突变类型。结果检出G1388A突变39例(72%),G1376T突变8例(15%),未定型者7例(13%)。未检出G95A。结论本研究首次对重庆市新生儿黄疸儿进行G1388A、G1376T和A95G突变检测。提示G1388A和G1376T为重庆市新生儿黄疸儿G6PD缺乏症基因突变的主要类型。ARMS法是一种简便、快速、经济的检测G6PD已知基因突变的方法。本研究发现这两种突变类型仅见于中国人和华裔人群,具有遗传学及临床意义。 相似文献