医学生抑郁情绪与家庭及生活事件的相关性研究

目的 探讨医学专业大学生抑郁情绪与家庭及生活事件的相关性，为早期干预提供科学理论依据。方法 采用自拟量表对482名医学专业在校大学生调查，并做影响因素分析。结果 大学生无抑郁或极轻微192人占39．8％；轻度209人占43．4％；中度58人占12％；重度23人占4．8％。生源地、父亲文化程度、专业满意度、人际关系的敏感、学习压力的大小、丧失因子、受惩罚因子和健康适应因子对大学生抑郁情绪的产生有显著影响，而性别、家庭类型和经济情况对医学专业大学生抑郁情绪产生关系不大（P〉0．05）。结论 要重视学生中存在的抑郁情绪问题，采取积极有效措施帮助学生消除抑郁情绪。     

我国大陆恶性高热病例的分析

目的 分析我国大陆恶性高热（MH）病例的临床资料，探讨诊断和治疗中应注意的问题。方法 检索中国生物医学文献数据库，收集1978年1月至2004年3月报道的MH病例34例，分析其流行病学特征、发病特点、临床表现、治疗及转归。结果 我国大陆报道的MH病例以青少年居多，男性多于女性，集中在口腔科手术（尤其是唇腭裂修补术）、骨科手术和小儿外科手术（尤其是先天畸形矫治术），典型的临床表现为突然发生的高碳酸血症、体温急剧升高和骨骼肌僵直等。诊断上主要是根据临床表现，尚未建立骨骼肌体外收缩试验方法，治疗上主要是对症处理，缺乏特效药物（丹曲林）。结论 近几年我国大陆MH病例逐渐增加，应加强对MH发病机制的研究，尽快建立MH的实验诊断标准，增强预防、诊断和治疗MH的能力。     

Differential role for the striatum and cerebellum in response to novel movements using a motor learning paradigm.

The aim of this pilot study was to examine the role of the striatum and cerebellum in the adaptation to a novel movement within a sequence of practiced movements using a motor learning paradigm. The performance of patients in the early or advanced stages of Parkinson's disease (PD) and of patients with damage to the cerebellum (CE) was compared, respectively to a group of aged and young matched controls on an adapted version of the Mirror-Tracing Test. In this task, subjects were required to trace a series of complex figures in two conditions: (1) a Practiced condition, in which the figures were composed of the juxtaposition of three simple designs that were extensively practiced before; and (2) a Mixed condition in which triads were created by replacing the last simple figure of the triads in the Practiced condition by a new simple figure that had never been traced individually before. Results showed that all clinical groups were slower than controls at tracing the Practiced triads. Most interestingly, however, only patients in the advanced stages of PD showed increased completion time to trace the triads in the Mixed condition. This suggests that a bilateral striatal dysfunction affects the ability to adapt to a novel motion within a sequence of practiced movements. Although exploratory, these results support a functional dissociation between the striatum and cerebellum in acquiring visuomotor skilled behaviors.     

Evaluation of the influence of the aqueous phase bioconstituent environment on the F-19 T1 of perfluorocarbon blood substitute emulsions

Oxygen-sensitive F-19 magnetic resonance imaging of perfluorocarbon compounds requires that fluorocarbon T1 changes correlate with the local Po₂ and not with the composition of the surrounding aqueous phase. The influence of various bioconstituents and paramagnetic ions within the aqueous phase on the F-19 fluorocarbon phase T1 for PFC emulsions was evaluated at 0.14 and 0.66 T. T1 was measured for FC-43, perflubron, and a fluorinated surfactant. Controlled variables introduced in the aqueous phase included annex solution constituents, blood, pH changes, and Gd-DTPA. For a constant Po₂, the F-19 T1s were independent of the emulsion constituents, blood concentration, and pH. For FC-43 and perflubron, F-19 T1 was independent of the Gd-DTPA concentration, while the aqueous phase T1 decreased by more than an order of magnitude. XMO-10 (smallest emulsion particle size) showed a slight decrease in F-19 T1 with increasing Gd-DTPA concentration at 0.66 T.     

38例视网膜母细胞瘤的临床和误诊分析

目的 探讨视网膜母细胞瘤（retinoblastoma，RB）的临床特征、病理分类和误诊原因，尽可能减少错误的临床诊治。方法 对我科于1999-2004年间收集的38例临床诊断为视网膜母细胞瘤（retinoblastoma，RB）的病例资料进行回顾性分析。结果在38例疑似病例中，34例病理诊断为视网膜母细胞瘤，4例为Coats病。结论掌握相关的影像学知识和综合分析疑难病例的临床资料将有助于视网膜母细胞瘤的正确诊断和处理。     

Design and conduct of occupational epidemiology studies: III. Design aspects of case-control studies

Currently available approaches for the design of occupational case-control studies are reviewed. An accompanying paper reviews methods of analysis. We commence by drawing a distinction between cohort-based and registry-based studies. Methods for selecting cases and controls are then reviewed, including cumulative incidence and incidence density sampling, matching, sources of controls, and issues in control selection. Finally, the advantages and disadvantages of the case-control approach are summarized.     

CT导向下经皮射频消融术治疗肾上腺恶性肿瘤

目的对29例肾上腺肿瘤患者行射频消融（RFA）治疗，研究其近期局部治疗效果、不良反应和副作用。方法肾上腺肿瘤患者共29例，病灶总数31个，其中直径≤2．0cm的病灶共5个，2．1-4．0cm者18个，4．1-6．0cm者5个，≥6．1cm者3个，经RFA治疗1个月后行螺旋CT双期增强扫描评价肿瘤治疗效果。结果上述病灶经消融治疗后达到完全坏死者分别为5个、18个、3个、2个。患者无严重并发症出现。结论RFA治疗安全可靠，副作用小，是治疗肾上腺恶性肿瘤的有效方法之一。     

MR频谱检测乳酸的脉冲序列优化研究

目的通过改变一系列脉冲序列参数，以利于乳酸的最佳检测与定量分析。方法制作含乳酸玻璃模型。改变一系列的MR脉冲序列参数，应用点解析频谱序列(point resolved spectroscopy，PRESS)和激励回波序列(stimulated echo acquisition，STEAM)获得乳酸模型的相应频谱。另外，对12例脑病变患者和2例健康志愿者进行磁共振频谱检查，测量出每个波峰的峰高，并绘出序列变化曲线图。结果STEAM各波峰的峰向与PRESS序列一致，但STEAM各峰高均低于同等条件的PRESS峰。随着TE时间的延长，用乳酸模型测出的乳酸峰的峰高一序列曲线图呈波浪状变化，正向双峰在TE=26、270ms时共振波幅达到最大绝对值，负向双峰在TE=135～160ms之间达到最大绝对值。脑病变患者和健康志愿者的扫描结果表明，乳酸峰在优化的序列高于非优化的序列。结论优化的脉冲序列更有利于乳酸的检测与定量分析。     

自杀行为及其干预的研究进展

自杀已经成为一个世界范围内的重大公共卫生问题。中国的自杀特征具有独特性。自杀行为的发生往往是内在因素与外部因素相互作用的结果，它与社会学、心理学、伦理学、生物学、精神病学等各方面密切相关。自杀原因虽然错综复杂，但我们要提高意识，认识到自杀是一种可以预防的公共卫生问题。