脑血管病生物样本库建设标准研究

目的 开发适合我国脑血管病精准医学研究的生物样本库建设及管理标准,为建设可开发共享的脑血管病生物样本库提供技术保障.方法 参考国际大型生物样本库建设经验,基于国际标准化组织等机构的标准化思路,形成我国脑血管病生物样本库建设标准框架,从场地设施、设备、操作规程、数据标准、信息化等多个维度,对样本库的建设提出技术要求.结果...     

论反垄断法对知识产权滥用行为的规制

知识经济时代,知识产权滥用导致的垄断问题成为市场垄断的重要方面,尤其是跨国公司滥用知识产权谋求垄断利益,已经给我国经济安全带来威胁。我国第一部《反垄断法》已颁布施行,但这部“经济宪法”对有关知识产权滥用的反垄断问题没有作出细致的规定。知识产权与反垄断法的关系及知识产权滥用的反垄断法后果是基本的理论问题,而理论与操作中的关键问题都是“知识产权滥用”的界定,这些有待于相关细则的出台。     

沙特工程承包市场开发的几点体会

结合作者在沙特乙烯项目中的工作,重点介绍了开拓沙特工程承包市场需要注意和借鉴的五个方面。     

关于奥运志愿者精神对党建教育意义的探析——让学生在参与中发现、实现自身的价值

奥运志愿者精神是北京奥运会的宝贵精神遗产。充分发挥奥运志愿者精神的社会教育作用,有利于提升当代大学生的奉献精神,激发其创新能力;同时,奥运志愿者精神也是培育大学生党员的重要载体。     

基于Matlab距骨快速图像分割与动画生成的算法

背景：骨科手术导航是利用计算机和机器视觉技术,使医师在计算机屏幕的指导下完成接骨手术。为了后续定位工作的开展,首先必须基于CT图像序列在计算机上对下肢骨进行图像分割、三维重建和动画显示,并对其位姿进行测量。 目的：在计算机上快速自动地实现距骨图像的分割、三维可视化及动画显示,为建立新型的足部手术导航系统搭建计算机显示平台。 方法：基于足部CT图像序列,提出下列算法并采用Matlab编程实现：①基于最大熵原则对足部图像进行阈值分割以提取其中所有足部骨骼。②将形态学算法与Live-wire算法相结合快速自动地从该足部骨骼图像中分割出距骨。③利用移动立方体法对距骨表面进行三维重建。④采用图形学函数生成与显示距骨旋转的动画场景。 结果与结论：实验结果表明,上述算法准确度高且以较少的时间在普通 PC机上实现了距骨的三维可视化工作,可应用于足部手术导航的计算机显示平台中。     

Early filiform needle acupuncture for poststroke depression: a meta-analysis of 17 randomized controlled clinical trials

OBJECTIVE: To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL: We retrieved data from the Chinese National Knowledge Infrastructure(1979–2012), Wanfang(1980–2012), VIP(1989–2012), Chinese Biomedical Literature(1975–2012), PubMed(1966–2012), Ovid Lww(–2012), and Cochrane Library(–2012) Database using the internet. SELECTION CRITERIA: Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the included articles scored at least 4 points on the Jadad scale. Exclusion criteria: other acupuncture therapies as treatment group, not stroke-induced depression patients, score 4 points, non-randomized controlled trials, or animal trials. MAIN OUTCOME MEASURES: These were the Hamilton Depression Scale scores, clinical effective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS: A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with filiform needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval(CI): 1.03–1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale(17 items) scores were lower than in the antidepressant drug group(mean difference =-2.34, 95%CI:-3.46 to-1.22, P 0.000,1). At 4 weeks, Hamilton Depression Scale(24 items) scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 articles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION: Early filiform needle acupuncture for poststroke depression can perfectly control depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs.     

疼痛科的建设与管理

疼痛学科是一门新兴的医学边缘性学科,就其管理而言,既有医学经典学科的共性,同时又具有一些特殊性。作者结合该院疼痛科的发展历程,认识到：多专业合作;稳定的人才队伍;人才梯队形成和人才培养;硬件设施的逐渐完善;重视学科科研教学;加强质量控制是搞好本学科建设和管理的关键性工作。     

Economical impact of plasma fractionation project in Iran on affordability of plasma-derived medicines

In Iran all transfusion services are concentrated under authority of one public and centralized transfusion organization which has created the opportunity of using plasma produced in its blood centers for fractionation. In 2008 voluntary and non remunerated Iranian donors donated 1.8 million units of blood. This indicates a 25/1000 donation index. After responding to the needs for fresh plasma and cryoprecipitate each year about 150000 L of recovered plasma are reserved for fractionation. In an attempt to improve both blood safety profile and availability and affordability of plasma derived medicines, Iran's national transfusion service has entered into a contract fractionation agreement for surplus of plasma produced from donated blood by voluntary non remunerated donors. In order to ensure safety of product produced, Iran has chosen to collaborate with international fractionators based in highly regulated countries. The main objective of this study was to evaluate the impact of contract plasma fractionation on the affordability of the plasma derived medicines in Iran. During 2006–2008, Iran's contract fractionation project was able to produce 46%, 18% and 6% of IVIG, Albumin and FVIII consumed in Iran's market, respectively. In contrary to IVIG and Albumin, due to fairly high consumption of FVIII in Iran, the role of fractionation project in meeting the needs to FVIII was not substantial. However, Iran's experience has shown that contract plasma fractionation, through direct and indirect effects on price of plasma derived medicines, could substantially improve availability and affordability of such products in national health care system.     

Le Toucher et la Paralysie : le rôle du toucher dans la construction de Soi et la relation à l’Autre

To touch, to be touched… The subject invites to reflexion when one is valid. What is the case for a person with cerebral palsy? How does she touch? What does she feel when she is being touched, massaged? The article refers, in a more global way, to the question of Touch, linked with our sensibility and our sensory experiences in our first relationships and our self-construction. It gives voice to persons suffering from cerebral palsy in the way of testimonies on their feelings of touch. What does it represent for them? How do they speak of their experiences? Their words questions our practices and our relationship to the other person in therapeutic touch and well-being touch, as well as their implications and complementarities.