陕西省黄陵县克山病家庭的流行病学调查分析

目的 探讨陕西省黄陵县克山病家庭的克山病患病聚集性。方法 随机抽取陕西省黄陵县店头镇及下属各乡的52户克山病家庭，对患者及亲属进行一般情况、临床表现、病程等疾病相关流行病学调查及分析。结果 黄陵县克山病亲属的克山病检出率（12．30％）明显高于2002年陕西省克山病的检出率（3．66％，χ^2=37.55，P〈0．01），也明显高于以往当地一般人群的检出率（6．37％，χ^2=13.11，P〈0.01）。家庭检出率在6个村都明显高于2002年的各村人群检出率。结论 调查发现克山病存在家庭聚集性。     

不同录取批次护理本科生学习投入情况的比较研究

目的了解以高考第一批次和第三批次录取的护理本科生学习投入的差异,为探索制定差异化的人才培养方案提供参考。方法应用学习投入问卷对中国医科大学以第一批次本科分数线录取的142名护理本科生和以第三批次本科生分数线录取的196名护理本科生进行调查。结果第一批次和第三批次的护理本科护生的学习投入问卷的评分分别为(57.86±15.27)分和(49.11±1.06)分,差异有统计学意义(P0.05)。护理本科生学习投入程度可归为四类,其中1类学生在学习投入程度最高,2类和3类居中,4类最低,第一批次护理本科生1~4类的比例分别为26.06%、32.39%、34.51%、6.34%,第三批次护理本科生学习投入1~4类的比例分别为10.20%、32.65%、40.82%、16.33%,护理本科生各学习投入类别间差异有统计学意义(P均0.05)。结论不同批次护理本科生的学习投入程度存在差异,教育工作者应结合学生的学习特点,展开有针对性的教育。     

Grid topologies for the self-organizing map

The original Self-Organizing Feature Map (SOFM) has been extended in many ways to suit different goals and application domains. However, the topologies of the map lattice that we can found in literature are nearly always square or, more rarely, hexagonal. In this paper we study alternative grid topologies, which are derived from the geometrical theory of tessellations. Experimental results are presented for unsupervised clustering, color image segmentation and classification tasks, which show that the differences among the topologies are statistically significant in most cases, and that the optimal topology depends on the problem at hand. A theoretical interpretation of these results is also developed.     

集束化护理提高小耳畸形患者再造耳清洁度的效果观察

目的 探索集束化护理提高小耳畸形清洁度的临床效果.方法 2019年1月成立品管圈小组,通过对再造耳清洁度的现况调查,分析影响清洁度的因素,设定目标、拟定对策并实施.结果 开展品管圈活动后,再造耳的清洁度得分由53分上升到81分,目标达成率为105％,进步率为53％.小组成员从解决问题的能力、积极性、品管圈手法掌握程度、...     

ICP: A novel approach to predict prognosis of prostate cancer with inner-class clustering of gene expression data

Prostate cancer has heterogeneous characteristics. For that reason, even if tumors appear histologically similar to each other, there are many cases in which they are actually different, based on their gene expression levels. A single tumor may have multiple expression levels with both high-risk cancer genes and low-risk cancer genes. We can produce more useful models for stratifying prostate cancers into high-risk cancer and low-risk cancer categories by considering the range in each class through inner-class clustering. In this paper, we attempt to classify cancers into high-risk (aggressive) prostate cancer and low-risk (non-aggressive) prostate cancer using ICP (Inner-class Clustering and Prediction). Our model classified more efficiently than the models of the algorithms used for comparison. After discovering a number of genes linked to prostate cancer from the gene pairs used in our classification, we discovered that the proposed method can be used to find new unknown genes and gene pairs which distinguish between high-risk cancer and low-risk cancer.     

医用粘胶相关性皮肤损伤的文献计量学分析

目的: 应用文献计量学方法,分析国内外医用粘胶相关性皮肤损伤（Medical adhesive-related skin injuries,MARSI）文献的研究主题和热点。方法: 检索Cochrane Library、PubMed、EMbase、Web of science、sinoMed、CNKI、Wanfang、VIP等数据库MARSI相关文献,检索时限为建库至2019年5月。采用SPSS 22.0 软件进行文献计量分析,利用gCLUTO统计对国内外高频主题词进行聚类分析。结果: 共纳入论文103篇,其中外文文献占总文献量的27.18%,中文文献占总文献量的72.82%。聚类分析将国内外高频主题词聚为4大类,依次为皮肤损伤及损伤类型、相关危险因素、风险评估及风险管理、护理干预措施。结论: MARSI仍是国内外研究的热点,其发病机制研究仍处于探索阶段,目前尚缺乏有效的预防策略,研究领域较局限。在今后的研究中,应加强MARSI预防的研究、注重多学科合作。     

结直肠癌术后无病与术后转移证候特点及演变规律系统评价

[主要目的]分析结直肠癌术后无病与术后转移证候特点及演变规律,为临床治疗提供依据。[资料来源]2009年3月至2011年5月辽宁中医药大学附属医院住院结直肠癌术后患者。[选择文献量及依据]第一诊断为结直肠癌,术后患者,病理诊断明确;中医四诊资料全面;同一患者多次入院证候发生明显变化时,重复纳入,共116例住院结直肠癌术后患者原始病历。[数据提炼规则及应用方法]对四诊资料(乏力,纳差,腹痛,腹胀,大便干,便溏,消瘦,恶心,呕吐,失眠,口干苦,咳嗽,肝区不适,尿频,尿少,舌质暗,舌红,苔腻,苔白,苔黄,少苔,脉沉,脉细,脉弦,脉滑等)量化,有记为1,无记为0。用Microsoft Excel软件建立数据库统计,以证候出现频次排列,按术后是否发生转移分析。[数据综合得出结果与结论]结直肠癌术后术后无病与术后转移多有乏力、纳差、苔白、脉沉、腹胀等肝郁脾虚,术后无病脾虚为主,术后转移肝郁突出,并多有咳嗽。结直肠癌术后术后无病治宜健脾益气兼疏肝、调节情志等;术后转移治宜重在疏肝解郁、健脾益气、宣肺止咳等。     

Techniques for clustering gene expression data

Many clustering techniques have been proposed for the analysis of gene expression data obtained from microarray experiments. However, choice of suitable method(s) for a given experimental dataset is not straightforward. Common approaches do not translate well and fail to take account of the data profile. This review paper surveys state of the art applications which recognise these limitations and addresses them. As such, it provides a framework for the evaluation of clustering in gene expression analyses. The nature of microarray data is discussed briefly. Selected examples are presented for clustering methods considered.     

一起不明原因急性肾小球肾炎流行调查

[目的]探讨急性肾小球肾炎的流行特征,分析病例在学校聚集发生的高危因素,为制定针对性防制措施提供依据。[方法]在医疗机构和学校搜寻病例,在发生聚集性肾炎病例的3所学校采用统一的调查表病例对照研究。对部分病例学生进行血清学检测和细菌培养。[结果]2005年7～11月,在2个相邻县共发病89例,死亡2例,病死率为2.2%,3所村小学发炎病例罹患率为7.2%,男性49例(55%),女性40例(45%),年龄从3～17岁,平均(10±3.3)岁。病例抗“O”检测阳性率为63.0%(17/27)、血清补体下降率100%(6/6),咽拭子培养β溶血性链球菌阳性率为66.7%(4/6)。各年级发病、是否住校和男女生发病差异无统计学意义。疾病发生与浮肿前上呼吸道感染明显相关(χ2=15.7,P﹤0.01),学生用手直接擦课桌是可能的危险因素(OR=2.3,95%CI:1.1～4.9)。本次急性肾小球肾炎流行范围较广,有明显的学校、年龄和家庭聚集性。[结论]该次急性肾小球肾炎的发病与咽部β溶血性链球菌感染有关。及时对上呼吸道感染学生的早期治疗,养成良好的卫生习惯,是预防链球菌感染后肾炎疫情的关键。