In order to determine whether dopamine plays a role in the control of neuropituitary function in pregnant women during labour, blood levels of nicotine (NSN)- and estrogen (ESN)-stimulated neurophysins were measured in 119 women treated orally with placebo (n = 59, control group) or 5 mg bromocriptine, a potent dopaminergic receptor agonist (n = 60, experimental group). Serum samples were taken before drug ingestion (basal sample) and at delivery. The serum basal concentrations of NSN and ESN were similar in both groups of pregnant women in labour. At delivery, serum ESN levels were similar in all women regardless of the treatment, whereas NSN concentrations were significantly lower in the bromocriptine-treated women than in those who were given placebo.In additional experiments the effect of 5 mg bromocriptine on the serum concentrations of NSN and ESN was tested for 6 hours after drug ingestion in 10 healthy, non-pregnant women and in 8 women in the 3rd trimester of pregnancy. Bromocriptine did not modify the circulating levels of NSN and ESN in either of these 2 groups of women.Since NSN and ESN are thought to be associated with vasopressin and oxytocin, respectively, these results indicate that in non-pregnant women and in pregnant women during late pregnancy dopaminergic stimulation with a dopaminergic receptor agonist does not inhibit the release of either vasopressin or oxytocin during rest. In contrast, dopaminergic receptor stimulation appears to play an inhibitory role in the regulation of vasopressin, but not oxytocin secretion in pregnant women in labour. 相似文献
We describe the longest-known continuous use of clomiphene citrate ever reported in a human. As a result of a pharmacy error, a woman took 50 mg/day clomiphene citrate for three months. The prolonged use of this medication resulted in ovarian hyperstimulation and unilateral oophorectomy for torsion. 相似文献
Objective: To investigate the efficacy of clomiphene citrate (CC) on normally ovulatory women who complained of infertility.
Design: A randomized study.
Setting: University Hospital.
Patient(s): Thirty-three normally ovulatory women with unexplained infertility.
Intervention(s): Eighteen women received CC at a 50-mg dosage. Fifteen women received no ovulation-induction drugs.
Main Outcome Measures: The pregnancy rate (PR) per patient, the PR per cycle, and the cumulative pregnancy rate.
Result(s): Seven patients in the CC group stopped taking CC, and observations were terminated because of antiestrogenic effects. The pregnancy rate (PR) per patient and the PR per cycle were significantly decreased (P < 0.005) in the CC group (4 of 18 [22.2%] and 4 of 66 [6.1%], respectively) than in the spontaneous group (11 of 15 [73.3%] and 11 of 52 [21.2%], respectively). Kaplan-Meier tests showed that the cumulative pregnancy rate in the CC group was significantly lower than in the spontaneous group (P <0.05). Five of seven patients who had stopped taking CC became pregnant in spontaneous cycles.
Conclusion(s): Administration of CC to normally ovulatory women is not efficacious in terms of increasing the pregnancy rate. 相似文献
Electroencephalographic (EEG) responses were recorded from preoptic, posterior hypothalamus and fronto-parietal cortical areas in mature male rats. Observations were made through stereotaxically implanted electrodes before and after an injection of clomiphene citrate (CC) in a dosage of 4 mg at varying time intervals in the same animal. The immediate response to CC injection was the occurrence of slow waves in preoptic, which later appeared in posterior hypothalamus. Slowing from posterior hypothalamus was very conspicuous, consisting of occasional high voltage rolling waves intermingled with low voltage fast components ending in discharges of long duration. Intermittent bursts of slow waves were observed as a regular feature from preoptic. By the end of two and a half hr, EEG activity of posterior hypothalamus was similar to that of preoptic. These EEG changes have been discussed with reference to hypothalamic control mechanisms for the secretion of gonadotrophins and libido display in the presence of CC. 相似文献