探讨心超和心电图在高血压性心脏病诊断中的临床价值

目的研究分析心脏B超以及心电图应用在高血压性心脏病临床诊断中的价值。方法抽取48例高血压性心脏病患者,将其按照每组24例划分为对照组和观察组,对照组通过心电图进行临床检查诊断,观察组则实施心脏B超检查诊断。结果观察组取得的诊断准确率为68.2%,显著高于对照组的38.7%(P0.05)。结论针对高血压性心脏病患者,采用心脏B超手段进行临床检查能够发挥良好的诊断效果,诊断准确性明显高于采用心电图检查。     

临床护士工作压力源调查分析及对策

目的通过研究临床护士的工作压力源，为探索减轻临床护士压力的方法和途径提供理论依据。方法采用护士压力源量表，利用随机分层抽样的方法，对我院内、外、妇、儿，四大临床科室共102名护士进行调查。结果临床护士在五个维度的压力源中，护理专业及工作方面的得分高于时间分配及工作量、病人护理、管理及人际关系、环境及设备方面，差异具有统计学意义（P〈0．01）。结论针对临床护士最突出的压力源特点，护士自身、医院和社会应采取有效对策，预防或减轻护士工作压力，以促进护士的身心健康及个人综合素质的普遍提升，不断提高护理质量。     

弹射式单兵快速骨髓腔输液器在急危重患者抢救中的应用

目的验证骨髓腔输液在急危重症患者抢救中的应用效果。方法对2014年1-3月来我院急诊的15例危重患者,在90s内未成功建立外周静脉通道时,进行了骨髓腔穿刺并输液,做好全程护理。结果 15例患者穿刺成功率为100%,均未发生相关并发症。结论骨髓腔输液快速便捷,操作简单易行,能作为急危重症患者抢救输液通道建立的操作方法。     

腹腔镜下与开腹子宫肌瘤剔除术的临床效果与并发症对比分析

目的:通过对比分析的方法探讨腹腔镜与开腹手术在子宫肌瘤剔除术中的临床效果与并发症情况。方法:选取2013年3月至2014年6月子宫肌瘤患者共156例,随机分为对照组和研究组,每组各78例。其中对照组采用传统开腹手术进行治疗,研究组采用腹腔镜手术的治疗方法,对比两组患者的临床治疗效果和并发症情况。结果:两组患者的手术时间无显著差异(P0.05),术中出血量、住院时间及术后排气时间情况研究组均明显优于对照组(P0.05);研究组患者的并发症发生率明显低于对照组(P0.05)。结论:腹腔镜用于治疗子宫肌瘤具有良好的临床治疗效果,能够减少治疗对患者造成的创伤,提高患者治疗体验并能有效降低并发症发病率,值得在临床上进行推广。     

Omentin-1 attenuates adipose tissue inflammation via restoration of TXNIP/NLRP3 signaling in high-fat diet-induced obese mice

Omentin-1 is an adipokine expressed by the adipose tissue and is reduced in obesity. This study was designed to calculate the protective efficiency and mechanism of omentin-1 against inflammation of the adipose tissue in obese mice. A transgenic mouse model with omentin-1 protein overexpression was established by crossing omentin-1 transgenic mice with Fabp4-Cre mice. Obesity was induced in the mice by feeding them a high-fat diet for 10 weeks. Fabp4-Cre-mediated overexpression of omentin-1 significantly increased serum omentin-1 level, serum anti-inflammatory factor levels, and expression of M2-specific mRNAs; inhibited body weight and adipose tissue weight gain; improved glucose tolerance, insulin tolerance, and insulin sensitivity; decreased serum levels of insulin and proinflammatory factors, adipocyte size, and expression of M1-specific mRNAs; suppressed macrophage infiltration; downregulated expression of proinflammatory factors; upregulated expression of anti-inflammatory factors; and inhibited thioredoxin-interacting protein (TXNIP)/NOD-like receptor 3 (NLRP3) signaling in the adipose tissue of obese mice. An NLRP3 inhibitor (20 mg/kg MCC950) exhibited the same effects as overexpression of omentin-1. Pretreatment with omentin-1 inhibited lipopolysaccharide-induced inflammation via TXNIP/NLRP3 signaling in RAW 264.7 macrophages. These findings suggest that omentin-1 suppresses adipose tissue inflammation in obese mice, at least partly, via inhibiting the TXNIP/NLRP3 signaling pathway.     

JNK信号通路在小鼠术后肠麻痹发病机制中的作用

目的 探讨JNK信号通路在小鼠术后肠麻痹（POI）发病机制中的作用。方法 将野生型C57/BL6小鼠（WT）及同品系的JNK-/-小鼠均随机分成假手术组（Sham组，n=6）和肠麻痹组（POI组，n=6）。采用经典小肠操作方法诱导POI模型，术后24h给小鼠碳末灌胃，20min后麻醉小鼠，开腹取小肠评估肠动力，取回肠评估组织学改变，检测髓过氧化物酶（MPO）、IL-1β、IL-6水平及Claudin-2蛋白表达。结果 与Sham组小鼠相比，无论WT或JNK-/-小鼠其POI组的小肠排推率（分别为21%与33%）均明显降低（P=0.034及P=0.045，均P<0.05），小肠组织MPO活性水平（分别为0.608U/g与0.433U/g）明显升高（均P<0.05）；与WT小鼠POI组比较，JNK-/-小鼠POI组的小肠运动功能及其组织病理变化有所改善，炎症介质如MPO、IL-1β及IL-6水平均有明显降低（均P<0.05），小肠Claudin-2蛋白表达也降低（P<0.01）。结论 JNK基因敲除减轻小鼠肠道炎症反应、改善POI，表明JNK信号通路参与POI的发病过程。     

Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency

An adult female patient was diagnosed with arginase 1 deficiency (ARG1-D) at 4 years of age, and had been managed with protein restriction combined with sodium benzoate therapy. Though the treatment was successful in ameliorating hyperammonemia, hyperargininemia persisted. After being under control with a strict restriction of dietary protein, severe fall of serum albumin levels appeared and her condition became strikingly worsened. However, after sodium phenylbutyrate (NaPB) therapy was initiated, the clinical condition and metabolic stability was greatly improved.Current management of ARG1-D is aimed at lowering plasma arginine levels. The nitrogen scavengers, such as NaPB can excrete the waste nitrogen not through the urea cycle but via the alternative pathway. The removal of nitrogen via alternative pathway lowers the flux of arginine in the urea cycle. Thereby, the clinical complications due to insufficient amount of protein intake can be prevented. Thus, NaPB therapy can be expected as a useful therapeutic option, particularly in patients with ARG1-D.     

L’adolescent aux diagnostics multiples ou le trouble dissociatif de l’identité à l’adolescence

ObjectiveTo evoke the notion of dissociative identity disorder in adolescence requires a nuance so many questions arise among others on the relevance of the juxtaposition of a complex disorder fluctuating at an age group marked by transition. In other words, is it appropriate to speak of dissociation of identity or multiple personality at this specific time of existence? It should also be noted that this diagnosis is controversial both because there is no consensus on definitions such as personality or identity and because some cultures take into account the possibility of possession to explain these tables without reference to pathology.MethodsTo illustrate our point, we will draw on the situation of a young person admitted to our institutional therapy centre located in a general hospital. The structure accommodates young people aged between fourteen and twenty for six to nine months. As we have also developed, these are usually directed in the course of ambulatory and/or residential therapeutic follow-ups, after experiencing moments of crisis or decompensation. The evaluation then carried out consolidates the prospect of a medium-term stay in a psychotherapeutic centre before considering a possible reintegration into daily life and activities. This clinical case illustrating the path of a teenager in prey to the tumults of wobbling of his identity causing confusion and uncertainty in the chief of the professionals encountered. The difficult situation experienced by this young person and his family questions on the one hand the relevance, the very basis of the diagnosis at this time of existence and on the other the notion of dissociative identity disorder in adolescence.ResultsThe dissociative identity disorder meets a number of criteria, the first of which is identity disturbance characterized by several distinct personality states. Clinically, we first observe a discontinuity in the integration of consciousness, of self-meaning. Registers of affects and sensory-motor functioning (perception, representation of the body) are also concerned. There are then disturbances of the agentivity (motor control, behaviors). In some cases, non-epileptogenic seizures and other conversive manifestations may be at the forefront of these complex clinical tables. The dissociative disorder of identity is also noticed by memory failures (dissociative amnesia) concerning the recall of daily events, personal information, which do not correspond to ordinary forgetfulness. This then leads to signs of impairment of social, professional or other relational functioning. Being an interruption in the tranquility of growth, adolescence is characterized by extreme conflicting positions, changing, fluctuating that give this period of life its appearance of tumult and crisis without being able to speak of frank psychic disturbances. Differential diagnosis between teen upheaval and true pathology is a difficult task.ConclusionsConsequently, we think it is important to pay attention to the diachronic and synchronic litters of what the young person in question is deploying. In order to do so, we advocate repeated clinical interviews with the patient and his or her entourage beside rigorous anamnesis. Time is an important element, the time of observation and encounter. Let us avoid precipitation without adopting an attitude of fatalism or even laxity, recalling that, for Winnicott, there is only one remedy for adolescence and only one; it is the passing time and gradual maturation processes that ultimately lead to the appearance of the adult person. Accompany a dissociative identity disorder, proven or suspected, includes the mobilization of a partnership envelope involving experienced institutional structures ready for the necessary clinical flexibility allowing continuous therapeutic adjustment.