Implicaciones bioéticas y médico-legales del uso de la fotografía en dermatología

Photographs are necessary in the clinical practice of dermatology, but there are ethical implications to consider. Moreover, dermatologists must be aware of and comply with certain legal requirements affecting the use of photographs. The main ethical principles are respect for patient autonomy and the physician's obligation to do no harm. The law differentiates between 2 bases for protection: one concerns the photographed person's rights over the image and the other protects personal data. Recent legislation places restrictions on taking photographs and exhibiting them. Photographs taken to be stored with a medical history have not been called into question, but the physician is recommended to inform the patient that they exist. When a photograph is exhibited for the purpose of teaching or illustrating concepts, it is necessary to determine whether or not the patient can be identified. If the answer is yes, the patient must give explicit permission. Caution should be exercised when publishing medical photographs on social media.     

Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling

Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin with antioxidant and anti-inflammatory properties. In this study, we explored the role and action mechanism of C3G in high glucose (HG)-induced damage of human nucleus pulposus cells (HNPCs). Cell viability was assessed by CCK-8 assay. TUNEL assay was performed for detecting apoptotic rate. Western blot was performed to determine the expression levels of cl-caspase-3, caspase-3, Bax, Bim, collagen II, aggrecan, MMP-3, MMP-13, and ADAMTS5. Reactive oxygen species (ROS) generation was analyzed using DCFH-DA staining. The Nrf2 was knocked down or overexpressed in HNPCs through transfection with si-Nrf2 or pcDNA3.0-Nrf2. C3G treatment (12.5, 25, and 50 μM) improved cell viability of HNPCs under HG condition. HG-induced cell apoptosis of HNPCs was attenuated by C3G with decreased apoptotic rate and relative levels of cl-caspase-3/caspase-3, Bax, and Bim. C3G treatment caused significant increase in expression levels of collagen II and aggrecan and decrease in the relative levels of MMP-3, MMP-13, and ADAMTS5. After treatment with C3G, ROS generation in HNPCs was markedly reduced. Treatment with N-acetylcysteine (NAC) reversed HG-induced cell apoptosis and extracellular matrix (ECM) degradation. C3G treatment induced the expression of Nrf2 and HO-1 in HG-induced HNPCs. Moreover, knockdown of Nrf2 reversed the inhibitory effect of C3G on ROS production. Summarily, C3G exerted a protective effect on ROS-mediated cellular damage in HNPCs under HG condition, which was attributed to the induction of the Nrf2/HO-1 signaling pathway.     

外固定架应用于创伤骨科治疗的临床疗效刍议

目的：对创伤骨科治疗中外固定架的应用效果进行研究。方法整群选取该医院2013年1月-2014年8月收治的创伤骨科患者164例，采用常规内固定的82例患者纳入对照组，利用外固定架治疗的82例划入观察组，对比分析两组患者切口长度、术中出血量、手术时间、治疗有效率以及并发症发生率。结果比较两组患者切口长度、术中出血量、手术时间，观察组都少于对照组。对比两组患者治疗有效率情况，观察组优、良、可、差分别为29例、36例、12例、5例，治疗有效为79.27%(65/82)，对照组优、良、可、差分别为19例、29例、22例、12例，治疗有效率为58.54%(48/82)。对比两组患者并发症发生率，观察组4.8%(4/82)低于对照组10.98%(9/82)，差异有统计学意义(P<0.05)。结论外固定架的引入，对提升创伤骨科治疗效果可起到突出作用，治疗有效率明显提高，可在临床实践中进行推广。     

BLB种植系统临床应用10年效果评价

目的评价BLB种植系统在国内应用10年以上的临床应用效果。方法搜集国内相关文献,运用寿命表法计算种植体的累积存留率。结果符合纳入标准的文献共16篇,有效植入数目为2677枚,最长随访时间为11年,BLB种植系统临床应用5年、10年的累积存留率分别为94.66%和91.16%。结论 BLB种植系统临床应用效果可靠,长期成功率较高,适应证广泛,是一种较理想的种植系统。