CLINICAL OBSERVATION ON TREATMENT OF STUBBORN HICCUP BY ACUPUNCTURE WITH DIFFERENT NEEDLE RETAINING TIME

Hiccupmayinfluence patients’dailylifeandworktodifferentdegrees.Thelightcasecanrecoverspontaneously ,buttheseriousonere sultingfromvariousacuteandchronicdiseasesmaykeepfordays,months,even years,nomatterdayornight,attackingintermittently .Acupuncturecantreatsuchsymptomeffectively ,butitisstilleasytoreoccurparticularlyinpa tientswithweakconstitution .Weacquiredsatis fiedtherapeuticresultthrough prolongingnee dle retainingin 45casesofstubbornhiccuppa tients.Followingisthereport.1　CLINICALDA…     

血管紧张素Ⅱ对人精子顶体反应的影响

目的 :探讨血管紧张素 (angiotensin ,Ang )对人精子顶体反应的影响及其可能机制。方法 :检测不同浓度 Ang 诱发的人精子顶体反应率和 Ang 引起的精子胞内钙离子的变化 ,以及血管紧张素受体 AT1拮抗剂 Losartan对其的抑制作用。结果 :Ang 在 1 0 nmol/L和 1 0 0 nmol/L时均可显著增加人精子顶体反应率 ,并引起精子胞内钙离子短暂快速升高 ,Losartan可以明显抑制这些过程。结论 :Ang 可以诱发人精子顶体反应 ,这一作用可能经 AT1受体介导 ,通过引起精子胞内钙离子升高而实现。     

前路Halm-Zielke器械治疗脊柱侧凸

目的　应用Halm Zielke双棒系统前路手术矫正脊柱侧凸。方法　 1999年 6月～ 2 0 0 0年 11月应用Halm Zielke系统治疗胸腰段和腰段特发性脊柱侧凸 10例 ,皆为女性 ,年龄 12 .5～ 18.4岁 ,平均 15 .7岁 ,全部病例均获随访。结果　术前侧凸Cobb’s角平均 5 7.1°,术后 14 .2° ,矫正率为75 .1%。旋转畸形 (Nash Moe法 )术前平均 2 .3° ,术后 0 .6° ,平均矫正 1.7°。除 1例轻度泌尿道感染外 ,无脊髓神经等其他并发症。结论　前路Halm Zielke手术矫正脊柱侧凸疗效确切 ,植入物稳定性好 ,并发症少 ,术后无须支架外固定     

温通针法减轻脑缺血损伤的实验研究——对脑缺血再灌注大鼠脑组织Ca及Mg元素含量的影响

目的观察温通针法治疗脑缺血的作用机理.方法用改良的四血管结扎法造成大鼠脑缺血及再灌注模型,观察脑组织Ca及Mg元素、脑组织含水量的变化及温通针法的干预效应.结果脑缺血再灌注后再灌组脑组织Ca元素及含水量显著增高(P<0.01),而Mg元素含量显著降低(P<0.01),用温通针法治疗后脑组织含水量、Ca元素含量明显降低(P<0.01),Mg元素明显升高(P<0.01).结论提示该针法具有明显减轻脑水肿,使再灌注脑组织Ca元素含量降低,Mg元素含量升高,从而减轻再灌注损伤的作用.     

我国红豆杉资源及可持续利用对策

本文阐述了我国红豆杉属植物的分布，紫杉醇含量和我国红杉资源状况，并对红豆杉资源的可持续利用问题进行了探讨。     

Cost and Utilization Impact of a Clinical Pathway for Patients Undergoing Pancreaticoduodenectomy

Background: When implemented in several common surgical procedures, clinical pathways have been reported to reduce costs and resource utilization, while maintaining or improving patient care. However, there is little data to support their use in more complex surgery. The objective of this study was to determine the effects of clinical pathway implementation in patients undergoing elective pancreaticoduodenectomy (PD) on cost and resource utilization.Methods: Outcome data from before and after the development of a clinical pathway were analyzed. The clinical pathway standardized the preoperative outpatient care, critical care, and postoperative floor care of patients who underwent PD. An independent department determined total costs for each patient, which included all hospital and physician costs, in a blinded review. Outcomes that were examined included perioperative mortality, postoperative morbidity, length of stay, readmissions, and postoperative clinic visits.Results: From January, 1996 to December, 1998, 148 consecutive patients underwent PD or total pancreatectomy; 68 before pathway development (PrePath) and 80 after pathway implementation (PostPath). There were no significant differences in patient demographics, comorbid conditions, underlying diagnosis, or use of neoadjuvant therapy between the two groups. Mean total costs were significantly reduced in PostPath patients compared with PrePath patients ($36,627 vs. $47,515; P = .003). Similarly, mean length of hospital stay was also significantly reduced in PostPath patients (13.5 vs. 16.4 days; P = .001). The total cost differences could not be attributed solely to differences in room and board costs. Cost and length-of-stay differences remained when outliers were excluded from the analysis. Despite these findings, there were no significant differences between PrePath and PostPath patients in terms of perioperative mortality (3% vs. 1%), readmissions within 1 month of discharge (15% vs. 11%), or mean number of clinic visits within 90 days of discharge (3.3 vs. 3.4 visits).Conclusions: The establishment of a clinical pathway for PD patients dramatically reduced costs and resource utilization without any apparent detrimental effect on quality of patient care. These findings support the implementation of clinical pathways for PD patients, as well as investigation into pathway care for other complex surgical procedures.     

Facilitated stimulus-response associative learning and long-term memory in mice lacking the NTAN1 amidase of the N-end rule pathway

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Inactivation of the NTAN1 gene encoding the asparagine-specific N-terminal amidase in mice results in impaired spatial memory [26]. The studies described here were designed to further characterize the effects upon learning and memory of inactivating the NTAN1 gene. NTAN1-deficient mice were found to be better than wild-type mice on black-white and horizontal-vertical discrimination learning. They were also better at 8-week Morris maze retention testing when a reversal trial was not included in the testing procedures. In all three tasks NTAN1-deficient mice appeared to use a strong win-stay strategy. It is concluded that inactivating the asparagine-specific branch of the N-end rule pathway in mice results in impaired spatial learning with concomitant compensatory restructuring of the nervous system in favor of non-spatial (stimulus-response) learning.     

2004～2006年医院抗菌药物的临床应用分析

目的：了解我院抗菌药物的应用情况和趋势，为临床合理用药提供参考。方法：对2004～2006年医院抗菌药物的品种、销售金额、限定日用量、用药频度、限定日费用进行统计分析。结果：2004～2006年每年抗菌药金额占西药总金额的份额分别为37.64%、34.06%、24.64%，构成比逐年下降；其中头孢菌素类零售金额各年均超过全年抗菌零售金额的50%，占主导地位；DDDs前10名药品中头孢菌素种类呈逐年上升趋势，大多数药物的治疗日费用（DDC）呈逐年降低的趋势。结论：抗菌药物使用基本合理，但仍存在用药过度、集中的问题。应严格执行《抗菌药物临床应用指导原则》，提倡安全、合理、有效、经济地应用抗菌药物。     

自拟活血降脂汤治疗高脂血症的临床观察

目的：观察自拟活血降脂汤治疗高脂血症的临床疗效。方法：将100例高脂血症患者随机分为对照组与治疗组，治疗组60例应用活血降脂汤，对照组40例以血脂康胶囊治疗。两组患者治疗12W后观察临床疗效、血脂[总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）]、载脂蛋白（ApoA-I、ApoB）及安全性指标。结果：两组患者治疗后，治疗组总有效率为90．0％，对照组为85．0％；两组总有效率比较，无显著性差异（P〉0．05）。在降低TG、ApoB和升高ApoA—I方面治疗组优于对照纽，两组比较有显著性差异（P〈0．05，P〈0．01）。两组中医证候疗效及治疗前后症状积分比较，有显著性差异（P〈0．01）。结论：活血降脂汤能明显改善血脂代谢，是一种疗效确切、应用安全的降血脂汤剂。     

反义ClC-3寡核苷酸对thapsigargin触发 的Ca2+ 运动的影响

 【目的】 研究反义ClC-3寡核苷酸对Thapsigargin (TG)触发的Ca2+ 运动的影响。【方法】 在PC12 细胞中转染反义ClC-3寡核苷酸,利用生物荧光影像分析系统测定胞浆Ca2+ 技术探讨ClC-3寡核苷酸对TG触发的Ca2+ 运动的影响。【结果】 与对照组相比,反义寡核苷酸转染对TG触发的PC12细胞静息[Ca2+]i的Ratio值和Ca2+ 释放量的Ratio值无显著影响(P>0.05)?但使Ca2+ 内流量明显升高(P<0.05)?Ca2+ 池操纵性Ca2+ 通道(store-operated Ca2+ channels, SOCC)阻断剂SK&;F96365可以浓度依赖的抑制TG触发的PC12细胞Ca2+ 内流,但与随义?正义寡核苷酸转染组相比, SK&;F96365对反义转染组细胞Ca2+ 内流的抑制作用明显增强(P<0.05)。【结论】 ClC-3蛋白参与TG触发的Ca2+ 池操纵的Ca2+ 内流(store-operated Ca2+ entry,SOCE),但对细胞静息钙水平及钙释放过程没有影响。