全文获取类型
收费全文 | 67881篇 |
免费 | 5643篇 |
国内免费 | 1598篇 |
专业分类
耳鼻咽喉 | 433篇 |
儿科学 | 1110篇 |
妇产科学 | 913篇 |
基础医学 | 5193篇 |
口腔科学 | 1614篇 |
临床医学 | 8116篇 |
内科学 | 7279篇 |
皮肤病学 | 1208篇 |
神经病学 | 1805篇 |
特种医学 | 4005篇 |
外科学 | 8123篇 |
综合类 | 10168篇 |
现状与发展 | 10篇 |
一般理论 | 4篇 |
预防医学 | 7095篇 |
眼科学 | 945篇 |
药学 | 4466篇 |
36篇 | |
中国医学 | 2120篇 |
肿瘤学 | 10479篇 |
出版年
2024年 | 191篇 |
2023年 | 1108篇 |
2022年 | 2652篇 |
2021年 | 3106篇 |
2020年 | 2933篇 |
2019年 | 2223篇 |
2018年 | 2360篇 |
2017年 | 2251篇 |
2016年 | 2525篇 |
2015年 | 2431篇 |
2014年 | 4935篇 |
2013年 | 4831篇 |
2012年 | 4343篇 |
2011年 | 4653篇 |
2010年 | 3684篇 |
2009年 | 3778篇 |
2008年 | 3767篇 |
2007年 | 3629篇 |
2006年 | 2999篇 |
2005年 | 2492篇 |
2004年 | 1999篇 |
2003年 | 1688篇 |
2002年 | 1420篇 |
2001年 | 1333篇 |
2000年 | 1111篇 |
1999年 | 860篇 |
1998年 | 809篇 |
1997年 | 703篇 |
1996年 | 472篇 |
1995年 | 575篇 |
1994年 | 497篇 |
1993年 | 323篇 |
1992年 | 326篇 |
1991年 | 288篇 |
1990年 | 222篇 |
1989年 | 248篇 |
1988年 | 203篇 |
1987年 | 195篇 |
1986年 | 148篇 |
1985年 | 165篇 |
1984年 | 114篇 |
1983年 | 62篇 |
1982年 | 88篇 |
1981年 | 75篇 |
1980年 | 71篇 |
1979年 | 63篇 |
1978年 | 38篇 |
1977年 | 35篇 |
1976年 | 30篇 |
1975年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
Diabetes mellitus(DM) negatively affects the development and progression of chronic liver diseases(CLD) of various etiologies. Concurrent DM and CLD are also associated with worse clinical outcomes with respect to mortality, the occurrence of hepatic decompensation, and the development of hepatocellular carcinoma(HCC). Unfortunately, early diagnosis and optimal treatment of DM can be challenging, due to the lack of established clinical guidelines as well as the medical complexity of this patient population. We conducted an exploratory review of relevant literature to provide an up-to-date review for internists and hepatologists caring for this patient population. We reviewed the epidemiological and pathophysiological associations between DM and CLD, the impact of insulin resistance on the progression and manifestations of CLD, the pathogenesis of hepatogenic diabetes, as well as the practical challenges in diagnosis and monitoring of DM in this patient population. We also reviewed the latest clinical evidence on various pharmacological antihyperglycemic therapies with an emphasis on liver disease-related clinical outcomes. Finally, we proposed an algorithm for managing DM in patients with CLD and discussed the clinical and research questions that remain to be addressed. 相似文献
52.
53.
《Clinical breast cancer》2020,20(6):454-461
BackgroundCoronavirus disease 2019 (COVID-19) has put a strain on regular healthcare worldwide. In the Netherlands, the national screening programs, including for breast cancer, were halted temporarily. This posed a challenge to breast cancer care, because ∼40% of cases are detected through national screening. Therefore, the aim of the present study was to evaluate the effects of the COVID-19 pandemic on the surgical care of patients with breast cancer in the Netherlands.Materials and MethodsThe present multicenter retrospective cohort study investigated the effects of COVID-19 on patients with breast cancer who had undergone surgery from March 9 to May 17, 2020. The primary endpoints were the number of surgical procedures performed during the study period, tumor characteristics, surgery type, and route of referral. The secondary endpoint was the incidence of postoperative complications during the study period.ResultsA total of 217 consecutive patients with breast cancer requiring surgery were included. We found an overall decrease in the number of patients with breast cancer who were undergoing surgery. The most significant decline was seen in surgery for T1-T2 and N0 tumors. A decline in the number of referrals from both the national screening program and general practitioners was observed. The incidence of postoperative complications remained stable during the study period.ConclusionsThe temporary halt of the national screening program for breast cancer resulted in fewer surgical procedures during the study period and a pronounced decrease in surgery of the lower tumor stages. 相似文献
54.
55.
56.
57.
Owen Ngalamika Gongping Liang Ming Zhao Xinhai Yu Yang Yang Heng Yin 《Immunological investigations》2015,44(2):126-136
Immune dysregulation is a cardinal feature of autoimmune diseases and chronic microbial infections. In particular, regulatory T cells are downregulated in autoimmune diseases while upregulated in chronic microbial infections. FOXP3 is the master regulator of Treg development. Treg-specific demethylated region (TSDR) is a highly conserved locus on the FOXP3 gene that is fully demethylated in natural Tregs but methylated in effector T cells. In our study, we used high resolution melt-polymerase chain reaction (HRM-PCR) to determine the FOXP3 TSDR methylation status in autoimmune diseases and chronic microbial infections. We found that FOXP3 TSDR to have the highest mean melting temperature (highly methylated) in active SLE patients compared to all the other groups (p?<?0.001). The psoriasis group also had a significantly high mean melting temperature (78.62?±?0.20) when compared with the inactive SLE group (78.49?±?0.29, p?<?0.05) and control group (78.44?±?0.25, p?<?0.01). There was no significant difference in melting temperature between inactive SLE and healthy controls. Disease activity in SLE was directly associated with methylation of the FOXP3 TSDR. On the other hand, patients with chronic microbial infections had significantly lower FOXP3 TSDR mean melting temperature (demethylated) when compared with healthy controls (78.28?±?0.21 vs 78.44?±?0.25, p?<?0.05). Our results suggest that the use of HRM-PCR to detect FOXP3 TSDR methylation status is a reliable and easy method to predict natural regulatory T cell levels in peripheral blood in different disease conditions. Determining FOXP3 TSDR methylation status can be a useful tool in diagnosis, and monitoring the severity of autoimmune diseases and chronic microbial infections. 相似文献
58.
Maggie L. Westfal David C. Chang Cassandra M. Kelleher 《Journal of pediatric surgery》2019,54(1):140-144
Purpose
The purpose of this study was to evaluate trends in demographics and outcomes of pediatric breast cancer in a United States population-based cohort.Methods
The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify all pediatric patients with malignant breast tumors between 1973 and 2014. Analysis was performed using Stata Statistical Software version 13.1. Associations between categorical variables were made using X2 test. Log-rank test was used for univariate survival analysis. Kaplan–Meier analysis investigated five-year survival rates across several variables. Adjusted analysis was performed using a Cox Proportional-Hazards regression.Results
134 patients with breast malignancies were identified. Carcinoma was the most prevalent histology (48.5%), followed by fibroepithelial tumors (FETs) (35.1%), and sarcoma (14.2%). FETs were twice as common in black compared to nonblack patients (56.3% vs. 29.0%, p?<?0.01). Analyzing histology by stage revealed that 100% of FETs were early stage disease (p?<?0.0001). 46.7% of the tumors tested were ER/PR negative, more than twice as many compared to the published adult estimate of 20.0%. Unadjusted survival analysis revealed worse survival for patients with adenocarcinoma/sarcomas, advanced stage, and high grade disease, without a survival difference between races.Conclusion
Breast cancer remains a rare malignancy among pediatric patients. Although black patients were found to have more noncarcinomatous tumors with less advanced disease, this did not confer a survival advantage.Type of study
Retrospective cohort study.Level of evidence
Level III. 相似文献59.
60.
Eitaro Ito Akihiro Takai Yoshinori Imai Hiromi Otani Yoshihiro Onishi Yosuke Yamamoto Kohei Ogawa Taiji Tohyama Shunichi Fukuhara Yasutsugu Takada 《Surgery》2019,165(2):353-359