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991.
Sergio Crosby Doanh Tran David Cocke El-Shazly M. Duraia Gary W. Beall 《Materials》2014,7(10):7048-7058
Hydrotalcites have many important applications in catalysis, wastewater treatment, gene delivery and polymer stabilization, all depending on preparation history and treatment scenarios. In catalysis and polymer stabilization, thermal decomposition is of great importance. Hydrotalcites form easily with atmospheric carbon dioxide and often interfere with the study of other anion containing systems, particularly if formed at room temperature. The dehydroxylation and decomposition of carbonate occurs simultaneously, making it difficult to distinguish the dehydroxylation mechanisms directly. To date, the majority of work on understanding the decomposition mechanism has utilized hydrotalcite precipitated at room temperature. In this study, evolved gas analysis combined with thermal analysis has been used to show that CO2 contamination is problematic in materials being formed at RT that are poorly crystalline. This has led to some dispute as to the nature of the dehydroxylation mechanism. In this paper, data for the thermal decomposition of the chloride form of hydrotalcite are reported. In addition, carbonate-free hydrotalcites have been synthesized with different charge densities and at different growth temperatures. This combination of parameters has allowed a better understanding of the mechanism of dehydroxylation and the role that isomorphous substitution plays in these mechanisms to be delineated. In addition, the effect of anion type on thermal stability is also reported. A stepwise dehydroxylation model is proposed that is mediated by the level of aluminum substitution. 相似文献
992.
993.
《Acta biomaterialia》2014,10(8):3557-3562
In the present study, the structure of two allogeneic and three xenogeneic bone blocks, which are used in dental and orthopedic surgery, were histologically analyzed. The ultimate goal was to assess whether the components postulated by the manufacturer can be identified after applying conventional histological and histochemical staining techniques. Three samples of each material, i.e. allogeneic material-1 and -2 as well as xenogeneic material-1, -2 and -3, were obtained commercially. After decalcification and standardized embedding processes, conventional histological staining was performed in order to detect inorganic matrix, cellular or organic matrix components. Allogeneic material-1 showed trabecular bone-like structures, which were free of cellular components as well as of organic matrix. The allogeneic material-2 showed trabecular bone structures, in which connective tissue and cellular remnants were embedded. Additionally, some connective tissue, which resembled fat-like tissue, was found within this material. The xenogeneic material-1 showed trabecular bone-like structures and contained organic components comparable to that demonstrated for the allogeneic material-2. The xenogeneic material-2 showed trabecular bone structures with single cells located in lacunae. The xenogeneic material-3 also showed trabecular structures. Neither cellular nor organic matrix components were found within this material. According to the data of the present study, the allogeneic material-1 and the xenogeneic material-3 were the only investigated materials for which the obtained histological data were in accordance with the manufactureŕs advertised information. The remaining three materials showed discrepancies—although the manufacturers of all five bone substitute materials stated that their blocks were free of organic/cellular remnants. These data are of great clinical and material science interest. It seems that even patented processing techniques are not always able to deliver reproducible materials. Although the manufacturers of all five bone blocks stated that their blocks were free of organic/cellular remnants, our histological analysis revealed that three out of five bone blocks did contain such remnants. Such specimens might be able to induce an immune response within the recipient. 相似文献
994.
995.
《Injury》2018,49(10):1732-1738
IntroductionIn the current study, we sought to determine if serum concentrations of MMPs correlate with bone regeneration occurring during the course of the Masquelet-therapy and to identify if MMPs may serve as early biomarkers reflecting successful bone regeneration and tissue remodeling.Material and methodsThis study was designed as a prospective clinical observer study. We compared serum samples over the time of treatment, as a matched-pair analysis, from 10 patients who were treated successfully with the Masquelet-therapy (Responder) with 10 patients who did not respond to the Masquelet-therapy (Non-Responder). The quantitative measurement was performed with Luminex Performance Human High Sensitivity Assays according to manufacturer’s instructions. The lab technician performing the Luminex assays was blinded to both patient data and clinical outcome.ResultsAnalysis of the expression pattern of MMP-2, -8 and -9 showed significant differences between groups. Two days after the first step of the Masquelet therapy Responder showed peak values of MMP-8 and MMP-9 that where significantly higher (p = 0.003 and p = 0.042, respectively) than in Non-Responder. In contrast serum levels of MMP-2 were lower after the first step of the Masquelet therapy in the Non-Responder group. The ratio of MMP-9 and MMP-2 was significantly higher in the Responder group two days after step I (p = 0.031) as well as 4 weeks after step II (p = 0.030).ConclusionThe findings of the current study emphasize the potential role of MMPs as biomarkers in bone remodeling. In particular, a distinct expression of MMP-2 correlates with successful bone regeneration, whereas initial overexpression of MMP-2 serum levels might identify patients that have a higher risk for a poor outcome of the Masquelet-therapy. Furthermore, we were able to introduce the serum analysis of the ratio of MMP-9 and MMP-2 as promising novel modality for early prediction of the outcome of the Masquelet therapy. Further analysis of this ratio over time subsequent to the second step might serve as an early indicator of a favorable response to the induced membrane technique. 相似文献
996.
《Journal of cranio-maxillo-facial surgery》2014,42(4):333-339
AimsThe purpose of this study was to evaluate the expression of proteins that participate in the osteoinduction stage (VEGF, BMP2 and CBFA1) of the process of bone regeneration of defects created in rat calvariae and filled with autogenous bone block grafts.Materials and methods10 adult male rats (Rattus norvegicus albinus, Wistar) were used, who received two bone defects measuring 5 mm each in the calvariae. The bone defects constituted two experimental groups (n = 10): Control Group (CONT) (defects filled with a coagulum); Graft Group (GR) (defects filled with autogenous bone removed from the contralateral defect). The animals were submitted to euthanasia at 7 and 30 days post-operatively.ResultsQuantitative analysis demonstrated significantly greater bone formation in Group GR, but the presence of the studied proteins was significantly greater in the CONT Group in both time intervals of observation.ConclusionIt was not possible in this study in cortical bone block groups to detect the osteoinductive proteins in a significant amount during the repair process. 相似文献
997.
Mark Sak Neb Duric Peter Littrup Lisa Bey-Knight Haythem Ali Patricia Vallieres Mark E. Sherman Gretchen L. Gierach 《Ultrasound in medicine & biology》2017,43(1):91-103
A population of 165 women with negative mammographic screens also received an ultrasound tomography (UST) examination at the Karmanos Cancer Institute in Detroit, MI. Standard statistical techniques were employed to measure the associations between the various mammographic- and UST-related density measures and various participant characteristics such as age, weight and height. The mammographic percent density (MPD) was found to have similar strength associations with UST mean sound speed (Spearman coefficient, rs = 0.722, p < 0.001) and UST median sound speed (rs = 0.737, p < 0.001). Both were stronger than the associations between MPD with two separate measures of UST percent density, a k-means (rs = 0.568, p < 0.001) or a threshold (rs = 0.715, p < 0.001) measure. Segmentation of the UST sound speed images into dense and non-dense volumes showed weak to moderate associations with the mammographically equivalent measures. Relationships were found to be inversely and weakly associated between age and the UST mean sound speed (rs = ?0.239, p = 0.002), UST median sound speed (rs = ?0.226, p = 0.004) and MPD (rs = ?0.204, p = 0.008). Relationships were found to be inversely and moderately associated between body mass index (BMI) and the UST mean sound speed (rs = ?0.429, p < 0.001), UST median sound speed (rs = ?0.447, p < 0.001) and MPD (rs = ?0.489, p < 0.001). The results confirm and strengthen findings presented in previous work indicating that UST sound speed imaging yields viable markers of breast density in a manner consistent with mammography, the current clinical standard. These results lay the groundwork for further studies to assess the role of sound speed imaging in risk prediction. 相似文献
998.
FRAX and mandibular sparse trabeculation as fracture predictors: a longitudinal study from 1980 to 2002 下载免费PDF全文
Valter Sundh Dominique Hange Margareta Ahlqwist Magnus Hakeberg Lauren Lissner Grethe Jonasson 《European journal of oral sciences》2017,125(2):135-140
The fracture assessment tool (FRAX) is widely used for predicting fractures, but better methods are needed. The aim of this study was to determine whether visual assessments of mandibular trabecular bone could improve FRAX predictions. Three age‐cohorts of women were examined twice – 499 women in 1980/1981 and 412 women in 1992/1993; 397 participated in both examinations. Information on 10‐yr fracture events was available, and bone trabeculation was assessed in radiographs as ‘dense’, ‘mixed’, or ‘sparse’. Fracture assessment tool values, without bone mineral density (BMD), were calculated twice. Both sparse trabeculation and FRAX >15% were associated with a twofold higher risk for future fracture in the younger group and with a three‐ to fourfold higher risk for future fracture in the older group. For those with both FRAX >15% and sparse trabeculation, the relative risk (RR) for a fracture in the next 10 yr was 5.9 (95% CI: 3.5–9.8) in the younger group and 22.7 (95% CI: 5.6–92) in the older group. If either FRAX >15% or sparse trabeculation was present, the RR was 2.6 (95% CI: 1.7–4.1) in the younger group and 15.7 (95% CI: 3.9–6.4) in the older group. We concluded that FRAX >15%, without BMD measurements, was an effective fracture predictor, and mandibular sparse trabeculation had a substantial additive effect. Together, FRAX plus mandibular sparse trabeculation predicts major osteoporotic fractures to approximately the same extent as does FRAX with BMD measurements. 相似文献
999.
目的荧光标记法观察比较4种表面处理方式种植体周围骨矿化沉积率的差异。方法微创拔除4只Beagle犬双侧下颌4颗前磨牙,待拔牙创愈合3个月后,植入奥齿泰种植体40颗,其中机械形态表面(ma-chined morphology,MM)组4颗,喷砂加酸蚀(sand blasted with alumina and acid etched,SA)组、可吸收性研磨介质(resorbable blasting media,RBM)组和生物化学喷砂酸蚀组(biochemistry sand blasted with alumina and acid etched,Bio-SA)组各12颗,愈合3个月,处死前13、14 d和3、4 d分别注射盐酸四环素和钙黄绿素,制取标本并置于70%酒精固定,采用塑料包埋技术制作骨磨片,荧光显微镜下观察,测量骨矿化沉积率。结果螺纹间及远离螺纹区域新骨矿化沉积率在4组间的差异均没有统计学意义(P>0.05);单独比较每组种植体螺纹间及远离区域骨矿化沉积率的差异性,RBM组及SA组组内差异没有统计学意义(P>0.05),而MM组和Bio-SA组组内差异具有统计学意义(P<0.05)。结论采用塑料包埋技术,通过荧光标记法能成功观察到新骨矿化沉积的情况;种植体植入3个月后,4种不同粗糙程度的种植体螺纹间及远离螺纹区域骨矿化沉积率没有差异性,而经机械形态表面处理的种植体和生物化学喷砂酸蚀处理的种植体,螺纹间骨矿化沉积比远离螺纹区域快。 相似文献
1000.
目的 研究影响包头地区人群骨密度的相关因素。方法 采用病例-对照研究方法。收集来自包头医学院第一附属医院进行健康体检的596例女性和230例男性流行病学资料,用双能X线吸收仪对研究对象进行骨扫描,按骨密度检测值分为正常对照组和骨质疏松及骨量流失组。采用 Logistic回归法分析影响骨密度的相关因素。结果 经Logistic回归分析,饮酒是女性发生骨质疏松的危险因素,吸烟、饮酒是男性发生骨质疏松的危险因素。补钙是人群保护因素。结论 包头地区 男、女性通过补钙均可预防骨质疏松;饮酒与女性骨量流失及骨质疏松显著相关,吸烟、饮酒与男性骨量流失及骨质疏松显著相关。 相似文献