首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3171篇
  免费   200篇
  国内免费   46篇
耳鼻咽喉   40篇
儿科学   383篇
妇产科学   17篇
基础医学   310篇
口腔科学   3篇
临床医学   357篇
内科学   309篇
皮肤病学   9篇
神经病学   450篇
特种医学   59篇
外科学   186篇
综合类   397篇
预防医学   491篇
眼科学   27篇
药学   236篇
  1篇
中国医学   29篇
肿瘤学   113篇
  2024年   3篇
  2023年   35篇
  2022年   89篇
  2021年   122篇
  2020年   96篇
  2019年   80篇
  2018年   90篇
  2017年   90篇
  2016年   107篇
  2015年   118篇
  2014年   187篇
  2013年   236篇
  2012年   186篇
  2011年   190篇
  2010年   133篇
  2009年   135篇
  2008年   156篇
  2007年   147篇
  2006年   148篇
  2005年   121篇
  2004年   92篇
  2003年   72篇
  2002年   60篇
  2001年   70篇
  2000年   59篇
  1999年   36篇
  1998年   49篇
  1997年   50篇
  1996年   39篇
  1995年   38篇
  1994年   38篇
  1993年   40篇
  1992年   22篇
  1991年   24篇
  1990年   32篇
  1989年   28篇
  1988年   20篇
  1987年   24篇
  1986年   16篇
  1985年   25篇
  1984年   25篇
  1983年   18篇
  1982年   20篇
  1981年   9篇
  1980年   15篇
  1979年   6篇
  1978年   6篇
  1977年   3篇
  1973年   4篇
  1970年   2篇
排序方式: 共有3417条查询结果,搜索用时 15 毫秒
11.
Cerebrospinal fluid (CSF) concentration-time curves of rifampicin and fusidic acid were studied in a patient with post-operative meningitis caused by Staphylococcus epidermidis. The patient was treated with this combination of antimicrobial agents because of a severe hypersensitivity reaction to vancomycin. Peak CSF concentrations of rifampicin exceeded the MIC by > 60-fold, while those of fusidic acid just reached the MIC. CSF concentrations of fusidic acid were relatively stable within the range reported for patients with uninflamed meninges, but serum levels were surprisingly low. An increase in the metabolism of fusidic acid induced by rifampicin cannot be excluded.  相似文献   
12.
Free amino acid concentrations of CSF were measured in bacterial meningitis, aseptic meningitis, meningoradiculitis Garin-Bujadoux-Bannwarth, multiple sclerosis, carcinomatous meningitis, and controls. Almost all CSF amino acids were highly elevated in bacterial but not in aseptic meningitis, meningoradiculitis Garin-Bujadoux-Bannwarth or carcinomatous meningitis thus providing a laboratory tool for their differential diagnosis. In carcinomatous meningitis the amino acid pattern indicates metabolic activity of tumor cells. Minimal alterations were found in multiple sclerosis which have no diagnostic value.  相似文献   
13.
①目的 探讨静脉注射大剂量人体丙种球蛋白 (IVIG)对儿童重症病毒性脑炎 (SVE)预后的影响。②方法 将 5 6例SVE病儿随机分为常规组 (n =2 2 ,给予抗病毒、降颅压、止惊、冬眠疗法、加压氧和糖皮质激素等常规治疗 )和IVIG组 (n =34,在常规治疗基础上尽量在 7d内给予IVIG ,剂量为每天 4 0 0~ 6 0 0mg/kg体质量 ,共2~ 3d) ,比较两组病儿治疗后的近期和远期预后 ,测定两组治疗前后血浆白细胞介素 6 (IL 6 )、肿瘤坏死因子 α(TNF α)水平并与对照组进行比较。③结果 与常规组比较 ,IVIG组治疗过程中呼吸衰竭、消化道出血、院内感染的发生率和病死率明显降低 (χ2 =6 .5 10~ 13.86 0 ,P <0 .0 5 ,0 .0 1) ;病后遗留脑性瘫痪者明显减少 (χ2 =4 .0 2 7,P <0 .0 5 ) ;病后 3,6 ,12个月IVIG组除瘫痪外 ,癫痫、脑影像学损害、脑电图和脑干听觉诱发电位异常者均明显减少 (χ2 =6 .4 5 1~ 4 5 .5 81,P <0 .0 5 ,0 .0 1) ;病后 6 ,12个月IVIG组的言语智商和总智商较常规组明显高 (t =2 .0 81~ 3.4 13,P <0 .0 5 ,0 .0 1)。IVIG组在病后 3,6个月时血浆IL 6 (15 .1,7.5ng/L)和TNF α(2 0 .4 ,11.8ng/L)水平较对照组 (4.2 ,8.5ng/L)明显升高 (z =- 3.337~ - 3.899,P <0 .0 1) ,但病后 12个月时血浆IL 6和TNF   相似文献   
14.
Intracranial pressure (ICP) monitored shortly after admission over a period of 1 h in 31 children with tuberculous meningitis (TBM) was significantly higher (median 22.5 mm Hg, range 8.4–50.9 mmHg) in 19 children with laboratory evidence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) than in 12 children without such evidence (median 16.2 mmHg, range 5.8–42.5 mmHg; P = 0.027). Neither plasma nor cerebrospinal fluid arginine vasopressin (AVP) was related to ICP (r = 0.33 and 0.13 respectively). Mean arterial pressure (MAP) was measured in 23 children and a moderate correlation was found with plasma AVP (r = 0.62; P = 0.0019). In TBM, plasma AVP may be secreted as a response to raised ICP in an effort to raise MAP and maintain cerebral perfusion pressure. In this setting excess fluid may be inappropriately retained, leading to hyponatremia and hypo-osmolemia.  相似文献   
15.
本告从23例临床上诊断为病毒性脑膜炎患者的脑脊液、血液中分离出柯萨奇B组病毒2株,未定型病毒1株,用所分离到的病毒与该患者恢复期血清做中和抗体测定均4倍或4倍以上升高,可以确定分离出的病毒与脑膜炎患者是相关的。同时检测57例脑膜炎患者恢复期血清中的柯萨奇B组病毒中和抗体,4倍或4倍以上升高者19例(33.3%)。40例健康人血清中柯萨奇B组病毒抗体阳性的(1:64)1例,两者差异显著(P<0.01)。结果表明,测定恢复期血清中和抗体结合临床对肠道病毒性脑膜炎的病因学诊断有一定的参考价值。  相似文献   
16.
国产氟康唑对小鼠隐球菌病的疗效   总被引:1,自引:1,他引:0  
以5×103cfu/鼠的新型隐球菌给小鼠脑室感染(ic)1h后,分别口服氟康唑(Flu)5和10mg/(kg·d)或酮康唑(Ket)50和100mg/(kg·d),bid×9d。对ic小鼠连续观察40天的存活率和平均存活时间,Ful分别为50%~70%和8~15天,Ket是30%~40%和5~9天。由小鼠侧尾静脉注射106cfu/鼠新型隐球菌3天后产生的全身感染,分别给小鼠口服Flu2.5~10mg/(kg·d)或Ket25~100mg/(kg·d),bid×9d。感染24、28和32天的PD50Flu是2.7、3.5和6.7mg/kg,Ket为28.4、70.4和83mg/kg;Flu和Ket的平均存活时间分别是23~34天和20~31天。在上述两种实验模型中分离脑和肺做细菌培养,Flu均与对照和50mg/(kg·d)的Ket比较,对ic10天及静脉注射感染13天的小鼠,口服5和10mg/(kg·d)或2.5~10mg/(kg·d)Flu均显著抑制新型隐球菌生长。  相似文献   
17.
Summary Reported in this paper is the first case of isolation ofPseudalle-Scheria boydii from cerebral spinal fluid of a boy with meningitis in China. Morphology and culture were observed by light microscopy, electron scanning microscopy and transmission electron microscopy. In addition, mycelium antigen prepared by SDS-PAGE was compared with that of the other strain of Scedosporium apiospermum. Both of the strains showed more than 40 peptide lines. Their molecular weight was very similar. On the CS-930 Dual-Wavelength TLC Scanner the peaks of both antigens showed to lie in nearly the same position. It could be concluded thatPseudallescheria boydii andScedosporium apiospermum belong to the same genus, but they are of different strains and reproductive phases.  相似文献   
18.
The first case of AIDS patient in the northern part of Thailand was reported in 1987 (Vithayasai et al., 1996), marking the outbreak of an epidemic. In our experience, the neurological involvement in AIDS patients seems to have changed in pattern and incidence during the last 8 years. We have conducted a retrospective study to review the incidence of AIDS-defining diseases in the patients admitted to Chiang Mai University Hospital, Thailand during the period September 2001 to August 2002. There were 155 AIDS patients admitted during this specified period, 118 of which were male and 37 female, aged between 16 and 60. The incidence of neurological complications was 50.3 per 100 person-years, in which central nervous system involvement account for 46.5 per 100 person-years and peripheral nervous system involvement account for 3.8 per 100 person-years. The incidence of cryptococcal meningitis appeared to be decreasing since 1994 whereas the incidence of cerebral toxoplasmosis appeared to be increasing. The incidence of cryptococcal meningitis, cerebral toxoplasmosis and cytomegalovirus (CMV) infection was 18.0, 14.8 and 7.0 per 100 person-years, respectively. Other common non-neurological AIDS-defining illnesses in northern Thailand include pulmonary tuberculosis (15.4 per 100 person-years), extra-pulmonary tuberculosis (9.6 per 100 person-years), and disseminated penicilliosis (12.2 per 100 person-years). In this way and summarizing, in northern Thailand, the three most common neurological involvements before the era of highly active anti-retroviral therapy are cryptococcal meningitis, cerebral toxoplasmosis and CMV infection. The incidence of cryptococcal meningitis appeared to be decreasing whereas the incidence of cerebral toxoplasmosis seemed to be increasing.  相似文献   
19.
We report a case of primary diffuse leptomeningeal gliomatosis (PDLG) followed up with serial magnetic resonance images (MRI). A 45‐year‐old man manifested with bilateral abducens nerve palsy and meningisms. Repeated MRI revealed diffuse leptomeningeal enhancement throughout the central nervous system without intra‐axial mass accompanied with the dilatation of ventricles and focally enlarged cerebral sulci. Brain biopsies showed a leptomeningeal gliomatosis. The MRI findings described here would contribute to the diagnosis of PDLG among other common diseases diffusely spreading along the leptomeningeal structures.  相似文献   
20.
小儿病毒性脑膜炎病原诊断与临床分析   总被引:9,自引:1,他引:8  
应用酶联免疫吸附(ELISA)方法,对88例临床诊断病毒性脑膜炎患儿急性期及恢复期脑脊液进行了单纯疱疹病毒(HSV-I、HSV-Ⅱ)、柯萨奇B组病毒(CoxBV)、埃可病毒(ECHO)、EB病毒(EBV)、腺病毒(AdV)及流感病毒(IFV)特异性IgM抗体检测。结果表明:HSV、CoxBV、ECHO、EBV、AdV、IFV病毒感染率分别为9.09%、18.18%、22.72%、3.41%、4.54%、5.68%;HSV及EBV感染致残率及病死率分别为87.5%(7/8)和100%(3/3)。提示脑脊液中病毒特异性IgM抗体检测可作为早期病原诊断的指标之一;CoxBV及ECH病毒是本地区小儿中枢神经系统病毒感染的主要病毒;HSV及EBV感染致残率及病死率较其它病毒高,预后不良;早期阿昔洛韦治疗,可大大降低病死率。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号