卫生专业技术资格人机对话考试B／S模式初探

利用网络技术实现无纸化考试,是近年来计算机领域的一个研究热点,而基于浏览器/服务器模式的在线考试系统是现代考试系统的发展趋势.文章以卫生专业技术资格人机对话考试为例,在分析了现有客户端/服务器模式系统不足的基础上,结合计算机网络技术的发展和素质教育要求,提出了基于3层体系(浏览器/服务器)结构的在线考试系统.     

基于B／S模式的大学英语等级考试报名系统的设计与实现

分析了大学英语等级考试新规定下的报名流程,提出了新系统所应该具备的功能需求,并在此基础上讨论了系统实现中的关键技术问题及其解决方法.     

Health related quality of life in patients with neuroendocrine tumors compared with the general Norwegian population

Purpose  Health related quality of life (HRQoL) was characterized among patients with neuroendocrine tumor (NET) and compared with the general Norwegian population. Methods  A cross sectional, comparative design was chosen, and the samples comprised 196 NET patients and 5,258 individuals from the general Norwegian population. We used Chi-square cross tab calculations to evaluate sociodemographic characteristics, T-tests for independent samples and Analysis of Variance (ANOVA) in order to compare HRQoL (SF-36) scores across a range of background variables. Furthermore, T-tests were used to analyze differences in HRQoL scores between the samples. Results  NET patients demonstrated significantly lower on all HRQoL subscales when compared with the general population with the lowest values on general health, physical limitation and vitality. Individuals above 70 years reported lower scores on physical functioning and physical limitations compared with those who were younger. Individuals with higher levels of education reported increased physical functioning compared with those with less education and full-time or part-time workers described higher physical functioning and less physical limitations compared with those who were retired. Conclusions  All SF-36 HRQoL scores were significantly lower among the NET patients when compared with the general population. Assistance from health personnel to NET patients should focus on those domains.     

基于.NET的标准化卫生机构信息管理系统的设计与实现

利用电子政务可以有效地提高政府的工作效率,减少政府办公支出,降低行政运营成本。其中,功能齐全、安全可靠的信息管理系统是实施政务信息化的有力保证。系统开发应用于标准化基层卫生机构信息管理工作中,发挥了较好的作用。     

用ASP技术实现国际疾病编码（ICD10）网络查询系统

目的：用微软的ASP技术来开发Web数据库应用程序,增强网络数据库在医疗方面的应用。方法：对ASP技术作了简单的说明,并就如何利用ASP连接数据库给出了具体的使用方法。结果：解决了医院和疗养院查询新版ICD10疾病编码的问题,保证了医务人员录入疾病编码的正确性。结论：普及了医务人员利用计算机开发Web数据库的程序和方法．提高了医务人员的工作效率。     

．NET框架TC／S结构社区慢病信息管理系统设计与实现

随着社会的发展。非传染性慢性疾病日趋增多,慢性病防治已刻不容缓,目前社区卫生服务逐渐成为慢病综合防治的最佳平台。实现对慢病患者信息的管理可以提高社区服务中心慢病服务的质量,加快分析和预测慢病发展的规律,为最终采取有效防治措施提供科学依据。主要研究基于．NET平台三层C／S结构的社区患慢病者信息系统。旨在提高社区工作人员和疾控中心的工作效率。     

某油田三元复合驱产能建设项目职业病危害预评价

目的识别、分析某油田三元复合驱产能建设项目拟采取的职业病防护设施是否符合要求及该建设项目的可行性。方法选择与该建设项目类似的类比现场进行类比调查,采用类比法与定量分级法相结合进行评价。结果该项目属职业病危害一般的建设项目;选址、总平面布置、生产工艺及设备布局合理,建筑物卫生学、拟采取的职业病防护设施设计、卫生辅助用室设施配置等符合国家卫生标准;该项目生产过程中可能产生的职业病危害因素有其他粉尘、非甲烷总烃、氢氧化钠、噪声和工频电场等。结论该建设项目拟采取的职业病防护设施基本符合国家职业卫生标准和卫生要求,从职业病预防角度考虑,该建设项目是可行的.     

An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females

The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05+/-3.07 years, mean+/-SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F=5.43, p=0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F=11.06, p=0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females.     

Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain

Irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (DAT), serotonin (SERT) and norepinephrine (NET). The present study characterizes the properties of the novel phenylisothiocyanate tropane HD-205, synthesized from the highly potent 2-napthyl tropane analog WF-23. In radioligand binding studies in brain membranes, direct IC(50) values of HD-205 were 4.1, 14 and 280nM at DAT, SERT and NET, respectively. Wash-resistant binding was characterized by preincubation of HD-205 with brain membranes, followed by extensive washing before performing transporter radioligand binding. Results for HD-205 showed wash-resistant IC(50) values of 191, 230 and 840nM at DAT, SERT and NET, respectively. Saturation binding studies with [(125)I]RTI-55 in membranes pretreated with 100nM HD-205 showed that HD-205 significantly decreased the B(max) but not K(D) of DAT and SERT binding. To further characterize its irreversible binding, an iodinated analog of HD-205, HD-244, was prepared from a trimethylsilyl precursor. The direct IC(50) of HD-244 at DAT was 20nM. [(125)I]HD-244 was synthesized with chloramine-T, purified on HPLC, reacted with rat striatal membranes, and proteins were separated by SDS-PAGE. Results showed several non-specific labeled bands, but only a single specific band of radioactivity co-migrating with an immunoreactive DAT band at approx. 80 kilodaltons was detected, suggesting that [(125)I]HD-244 covalently labeled DAT protein in striatal membranes. These results demonstrate that phenylisothiocyanate analogs of WF-23 can be used as potential ligands to map distinct binding sites of cocaine analogs at DAT.