Mechanisms for regulation of gastrin and somatostatin release from isolated rat stomach during gastric distention

AIM: To investigate the intragastric mechanisms forregulation of gastric neuroendocrine functions during gastricdistention in isolated vascularly perfused rat stomach.METHODS: Isolated vascularly perfused rat stomach wasprepared, then the gastric lumen was distended with either5,10 or 15 ml pH7 isotonic saline during a period of 20 min.During the distention, the axonal blocker tetrodotoxin (TTX),the cholinergic antagonist atropine, or the putativesomatostatin-antagonist cyclo [7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)] were applied by vascular perfusion. Thereleases of gastrin and somatostatin were then examinedby radioimmunoassay.RESULTS: The graded gastricdistention caused a significantvolume-dependent decrease in gastrin secretion [-183±75 (5ml), -385±86 (10 ml) and -440±85 (15 ml) pg/20 min] and asignificant increase of somatostatin secretion [260±102 (5 ml),608±148 (10 ml) and 943±316 (15 ml) pg/20 min]. In responseto 10 ml distention, the infusion of either axonal blocker TTX(10-6 M) or cholinergic blocker atropine (10-7 M) had a similaraffect. They both attenuated the decrease of gastrin releaseby approximately 50 %, and attenuated the increase ofsomatostatin release by approximately 40 %. The infusion ofsomatostatin-antagonist cyclo [7-aminoheptanoyl-Phe-D-Trp-Lys-Thr (Bzl)] (10-6M) attenuated the decrease of gastrin releaseby about 60 %. Furthermore, combined infusion of thesomatostatin-antagonist and atropine completely abolisheddistention-induced inhibition of gastrin release.CONCLUSION: The present data suggest that distention ofisolated rat stomach stimulates somatostatin release viacholinergic and non-cholinergic TTX-insensitive pathways. Bothsomatostatin and intrinsic cholinergic pathways are responsiblefor distention-induced inhibition of gastrin release.     

胃胀舒合剂对功能性消化不良大鼠胃排空及血浆胃肠激素水平的影响

[目的]观察胃胀舒合剂对功能性消化不良（FD）大鼠胃排空和胃肠激素的影响，探讨其可能的作用机制。[方法]采用不规则进食加稀盐酸喂养以及劳倦过度的复合因素制作大鼠FD模型。随机分成胃胀舒合剂高、低剂量（高、低剂量）组、多潘立酮组、正常对照（正常）组、模型对照（模型）组共5组，连续给药14d后，放免法检测血浆胃动素（MOT）和生长抑素（SS）水平，以酚红法观察胃排空。[结果]与正常组相比，模型组胃排空和血浆MOT水平显著降低，SS显著升高（均P〈0．05），与模型组相比，高、低剂量及多潘立酮组胃排空和血浆MOT显著升高，SS显著降低（均P〈0．05）。[结论]胃胀舒合剂具有促进内源性MOT及抑制SS释放和促进胃排空作用，是其治疗FD机制之一。     

老胃胀,最好去查胃镜

难得星期天在家休息，打开电视正在播演员岳红胃癌术后康复情况。对于岳红大家都应该很熟悉，大约是在20世纪80年代中期，她在一个小品中表演的农村的卖“花生仁”姑娘和另外一个姑娘在卖摊前羞涩地谈自己在部队当兵的对象，惟妙惟肖地表演使全国的观众耳目一新。当时她还是北京电影学院的学生，这个小品是她的功课，在电视上播出后在全国引起了轰动，我对小品的认识就是从她开始的。[编者按]     

反复腹痛胃胀 祸起十二指肠

73岁的李大爷,27多年来反复出现心窝部饱胀、疼痛,曾在多家医院行胃镜检查,报告为十二指肠球炎,经对症治疗,时好时坏,苦不堪言。     

江杨清效方治验——连苏胃胀饮

1 连苏胃胀饮 组 成:黄连6 g,连翘12 g,紫苏梗10 g,陈皮10 g,香附10 g,炒枳壳10 g,白豆蔻6 g,炒麦芽15 g,莱菔子15 g,法半夏10 g. 功 效:清胃除胀,行气消导. 主 治:多种慢性胃炎和消化不良以及精神情绪因素所致的胃脘胀满、反酸烧心,饭后为甚,屡用胃动力西药乏效者(肝胃气郁化热...     

论消积导滞法在慢性萎缩性胃炎治疗中的重要性

近现代医家认为慢性萎缩性胃炎多由脾胃虚弱、胃阴亏虚,兼夹寒凝、热郁、气滞、血瘀、湿阻、食滞等因素诱发而成,主要临床表现可见胃脘疼痛、痞满饱胀、嗳气、嘈杂、食欲不振等。笔者认为,在治疗本病时,若患者以食欲不振为主诉者,或纳呆食少,或食后饱胀,皆可以消积导滞法为基本大法,以保和丸为基础方,再进一步辨证分型,或兼以健脾益气,或兼以滋养胃阴,或兼以疏肝和胃,或兼以破瘀散结,或兼以通腑泻热等法,随证加减,灵活遣方用药。     

协和中医临床诊治经验荟萃（4）乏力、胃胀、恶心、肝功能异常

1病例摘要某女,68岁,已婚。因“乏力、胃胀、恶心、肝功能异常1月余”于2005年11月2日入院。     

针刺双侧足三里治疗胃胀30例临床观察

胃胀为中医病名,胀病之一,主证胀满、胃脘痛。《灵枢.胀论》:胃胀者,胀满,胃脘痛,鼻闻焦臭,妨于食,大便难。目前治疗主要是加强胃动力,但长期服用会造成人体的依赖性;由于药物是化学合成,对人体存在着副作用。针刺     

生脉饮合益胃汤治疗气阴两虚型胃胀30例

目的观察生脉饮合益胃汤加减治疗运动员气阴两虚型胃胀的临床疗效。方法对30例气阴两虚型胃胀患者采用益气养阴和胃法进行治疗,并观察临床疗效。结果30例患者中优知例,占86．7％,良4例,占13．3％,总有效率100％。结论生脉饮加益胃汤加减治疗运动员气阴两虚型胃胀疗效确切。     

胃胀六年无食欲 健脾消滞胃口行

十一黄金周来临之际,秋天的果实摆满了货架．苹果有红红的富士、半红半绿的国光、黄色的元帅,还有紫色的葡萄、橙色的柑橘……琳i良满目,