引人入胜宝岛游

大陆游客台湾游的开放给我们揭开了宝岛台湾的神秘面纱，只能在电视上看到的美丽景色、无数次在书本上读到的特色名吃、听到耳朵生茧的城市地名……这下子终于可以身临其境地感受一把了。那么，哪些地方是我们的宝岛之行所不可不去的呢？     

医海拾贝

嚼槟榔让女性面临心脏病的危险。中国台湾的一项人群研究发现，男性嚼槟榔的比例高于女性（分别为31％和2．4％），但心脏病患病率在两者间无显著差异（American Journal of Clinical Nutrition 2007；85：1229-35，www．ajcn．org）。每日嚼槟榔的次数与心脏病的患病率独立相关；女性每13嚼10个槟榔的关联比值比为1．37（95％CI1．1～1．6，P=0．003）。     

槟榔 御瘴舒心的佳果

槟榔，是一种棕榈科常绿乔木，树干直而高耸，顶端羽状复叶，花呈银白色，果实就是槟榔，呈长椭圆形。原产于东南垭和澳洲热带地方。我国早在2000年前，就有移栽，目前主要分布海南岛、台湾省和云南、广西等少数民族聚居的地区。     

洋蓟叶提取物的生物活性研究

洋蓟别名朝鲜蓟、菊蓟、菜蓟、法国百合、荷花百合,学名Cynara scolymus L.,为菊科菜蓟属多年生草本植物,原产地中海沿岸,目前欧美和非洲部分地区种植较多。19世纪由法国传入我国上海,目前我国在上海、浙江、湖南、云南等地有栽培,在台湾省有较大面积种植。洋蓟有较高营养价值,是一种保健蔬菜,常制成罐头,每100g花苞可食部分中含蛋白质2.8g、脂肪0.2g、糖9.9g、VA160NP单位、VB10.06mg、VB20.08mg、VC11mg、钙51mg,还含有菜蓟黄酮化合物及天门冬酰胺等对人体有益成分。洋蓟叶提取物(artichoke leaves extract,ALE)具有较高药用价值,在…     

与朱丹玩转全台湾与朱丹玩转全台湾

流火的七月,当红女主播、Lumi胶原蛋白代言人朱丹,携手《瑞丽》、《ELLE》、《VOGUE》、《昕薇》、《米娜》、《新浪》、《网易》、《腾讯》等24位时尚美容教主赴约“Lumi营养美容台湾行”。从名流汇集的台北市到美丽的高雄港,从原著居民集聚的“世外桃源”屏东县,再到拥有“台湾的马尔代夫”之称的垦丁。     

中华医学会第十次全国医学信息学术会议纪要

中华医学会第十次全国医学信息学术会议于2004年11月8日～12日在海南省海口市召开。来自全国21个省、直辖市、自治区、特区（包括台湾省和澳门特区）、解放军系统以及美国的148名代表参加了会议。开幕式由分会副主任委员徐一新教授主持。中华医学会副会长、分会名誉主任委员肖梓仁教授代表中华医学会总会和医学信息学分会致开幕词,分会主学信息学分会致欢迎词。海南医学会秘书长符永健教授代表海南医学会致欢迎词。会议具体内容如下。[编者按]     

第五届海峡护理论坛在台北成功召开

<正>2014年11月1³日,第五届海峡护理论坛在美丽的宝岛台湾省台北市隆重召开。以中华护理学会副理事长姜小鹰教授为团长的91名大陆护理界代表参加了此次盛会。大会由护理师护士公会台湾联合会指导,台湾海峡两岸医事交流协会主办,台湾护理管理学会承办,福建省护理学会等协办。台湾海峡两岸医事交流协会理事长黄松雄、护理师护士公会台湾联合会理事长卢美秀代表台方致欢迎词,中华护理学会副理事长、     

Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese

AIM: Single nucleotide polymorphisms (SNPs) of uridinediphosphoglucuro -nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this gene for Taiwan Chinese. METHODS: We collected blood samples from 112 healthy adults and 505 subjects carrying different genotypes of UGT1A1, and determined the promoter area and the entire sequence of UGT1A7 exon 1 by polymerase chain reaction. We designed appropriate primers and restriction enzymes to detect variant UGT1A7 genotypes found in the study subjects. RESULTS: Six SNPs at nucleotides 33, 387, 391, 392, 622, and 756 within the coding region of UGT1A7 exon 1 were found. The incidence of UGT1A7*l/*2 (N129R131W208/ K129K131W208) was predominant (35.7%) while that of UGT1A7 *3/*3 (K129K131R208/K129K131R208) was the least (2.7%). The allele frequency of UGT1A7*3, which exists in a considerable proportion of Caucasians (0.361) and Japanese (0.255), was identified only to be 0.152 in our study subjects. A novel variation at nucleotide -57 in the upstream was found, which was associated with SNPs at nucleotides 33, 387, 391, 392, and 622 in one of the variant haplotypes. The nucleotide changes at positions 387, 391, 392 and 756 were in linkage in another variant haplotype. The allele frequency of UGT1A7*3 was 0.018, 0.158, 0.242, 0.433, and 0.920 in subjects carrying wild, A(TA)6TAA/A(TA)7TAA, A(TA)7TAA/A(TA)7TAA, 211G/211A, and 211A/211A variants of UGT1A1 gene, respectively. By using natural or mutagenesis primers, we successfully detected the variations at nucleotides -57, 33, 387, and 622 with the restriction enzymes HpyCH4 Ⅳ, TaqⅠ, AflⅡ, and Rsa Ⅰ, respectively. CONCLUSION: The results indicate that the allele frequencies of UGT1A7 gene in Taiwan Chinese are different from those in Caucasians and Japanese. Carriage of the nucleotide 211- variant UGT1A gene is highly associated with UGT1A7*3. The restriction-enzymedigestion method for the determination of nucleotides-57 (or 33, or 622) and 387 can rapidly identify genotypes of UGT1A7 in an individual.     

Peanut consumption and reduced risk of colorectal cancer in women： A prospective study in Taiwan

AIM: To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS: In 1990-1992, residents (12026 men and 11917 women aged 30 to 65 years) in 7 townships, Taiwan, were interviewed and recruited into a cancer-screening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS: During the study period, 107 new colorectal cancer cases (68 men and 39 women) were confirmed. The multivariate Cox's proportional hazard model showed that the relative risk (RR) of peanut consumption was 0.73 [95% confidence interval (CI) =0.44-1.21] for men and 0.42 (95% CI =0.21-0.84) for women. However, frequent intake of pickled foodstuffs was harmful for women (RR = 2.15, 95% CI =0.99-4.65). The risk of colorectal cancer was also elevated among cigarette smokers but not significant (P<0.05). CONCLUSION: This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake.     

Expression and prognostic role of molecular markers in 99 KIT-positive gastric stromal tumors in Taiwanese

AIM:To elucidate the prognostic role and relationship ofthree molecular markers such as tumor suppressor genep53,proliferating cell nuclear antigen(PCNA)and Ki-67in gastric stromal tumor.METHODS:A total of 108 surgically resected gastricsmooth muscle tumor specimens were collected fromJanuary 1987 to December 1999.Immunohistochemicalstudies were performed on the paraffin sections of 99of 108 CD117-positive tumors with antibodies of p53,PCNA,and Ki-67.Immunoreactivity of three molecularmarkers was recorded by labeling index(LI,%)and wasanalyzed for clinicopathologic and survival correlation.RESULTS:Of the 99 cases,immunostaining revealedthat 52 patients(52.5%)had p53,and 37 patients(37.3%)had Ki-67 immunoreactivity(defined as>10%of LI).All patients(100%)had PCNA immunoreactivityranging from 12% to 93% of LI,divided into high orlow by median.Statistics revealed that LI of threemarkers positively correlate to each other(P<0.01)and to microscopic tumor mitotic counts(P<0.001).By combination,patients with≥2 markers(positiveor high)in tumors had early tumor recurrence(P<0.001)and unfavorable outcome(P<0.001).Univariate analysis indicated that patients with tumorsize>5 cm(P=0.003),tumor mitosis>5/50 HPF(P<0.001),p53 immunoreacUvity(P=0.001),Ki-67 immunoreactivity(P=0.026),high PCNA LI(P=0.015)and male gender(P=0.036)were six predictors for earlydisease recurrence.Subsequent multivariate analysisrevealed that mitotic counts,tumor size,and p53immunoreactivity were three independent prognosticfactors for both disease free and overall survival ofpatients.By combination of three independent prognosticfactors for grouping,we found higher tumor recurrencerate(P<0.001)and shorter survival(P<0.001)existed ingroups with increasing factors.CONCLUSION:We first provide the prognostic valueand linkage of three molecular markers in GISTs.Thecombination of three factors(p53,tumor size,andtumor mitosis)provides a more powerful prediction ofprognosis than any single factor does.