A protease inhibitor attenuates gastric erosions and microcirculatory disturbance in the early period after thermal injury in rats

The effects of camostat mesilate, a synthetic serine protease inhibitor on gastric microcirculation and active oxygen species generated by leucocytes from the gastric and jugular veins in the early period after thermal injury were assessed. Male Wistar rats were anaesthetized and a 30% full skin-thickness dorsal burn was inflicted. Camostat mesilate (100 mg/kg) was dissolved in distilled water and administered orally to rats 40 min before thermal injury (the camostat group). The control animals (the vehicle group) were administered distilled water orally. Rolling leucocytes as well as Monastral blue B deposits in venules were observed using in vivo microscopy. Active oxygen species were measured by chemiluminescence. Camostat mesilate decreased the total length of gastric erosion, venular deposits of Monastral blue B, and rolling of leucocytes in venules, and relatively increased luminol-dependent chemiluminescence activity generated by zymosan-stimulated leucocytes 15 min after thermal injury. These results suggest that serine proteases are involved in the formation of gastric erosions and gastric microcirculatory disturbance in the early period after thermal injury.     

Gene therapy of amyotrophic lateral sclerosis

Two-year experiments were performed to evaluate the neurotrophic effect of hypoxia-inducible factors (vascular endothelial growth factor and angiogenin) expressed in recombinant human adenoviruses in amyotrophic lateral sclerosis. Randomized placebo-controlled trial demonstrated safety and good tolerability of the recombinant antiviral drugs. The life span of patients under conditions of hypoxia increased after treatment with the test drug, which was probably related to improved resistance of motoneurons. The presence of virus-neutralizing antibodies decreases the effectiveness of adenoviral vectors, which necessitates differential approach to the selection of patients and continuous monitoring of gene therapy. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 4, pp. 467–470, April, 2008     

多功能红外治疗仪治疗宫颈糜烂86例疗效观察

目的　探讨多功能红外治疗宫颈糜烂的疗效。方法　将 171例宫颈糜烂患者随机分为两组 ,治疗组用多功能红外治疗仪探头点状光凝子宫颈 ,每点 2～ 3秒 ,对照组用CO2 激光治疗。结果　治疗组治愈 84例 ,占 97.67% ,对照组治愈 73例 ,占 85.88% ,两组疗效比较P <0 .0 5。结论　采用多功能红外治疗仪治疗宫颈糜烂疗效明显优于对照组。     

中西医结合治疗宫颈糜烂50例观察

目的：观察恒和坤净栓联合波姆红外光治疗宫项糜烂的疗效。方法：中西医结合组50例用恒和坤净检与波姆红外光治力仪联合治疗；对照组50例，单用波姆红外光治疗仪治疗。结果：中西医结合组痊愈率82％，对照组痊愈率40％。结论：中西医结合疗效较好，优于单用西医治疗。     

MEBO配合微波治疗宫颈糜烂疗效观察

目的探讨美宝湿润烧伤膏(MEBO)配合微波治疗宫颈糜烂的效果。方法2005年10月～2007年6月,173例宫颈糜烂患者随机分为A、B两组,月经干净后3～7天,均采用WNZ普通型微波治疗仪治疗,微波输出功率为50W。A组(89例)单纯采用微波治疗,B组(84例)先用微波治疗,治疗后创面局部涂抹MEBO,2个月内避免盆浴,4个月内禁止性生活。结果A、B两组中,轻度糜烂Ⅰ°组单纯采用微波治疗有效率94.7%,合用MEBO有效率100%,两组无明显差异,而痊愈率A组为71.0%,B组加用MEBO高达86.8%,经x2检验P<0.05,差异有显著性。在Ⅱ°、Ⅲ°单纯微波治疗中,A组有效率分别为62.2%和42.9%,痊愈率分别为16.2%和0%,B组经加用MEBO,其有效率分别为100%和85.7%,痊愈率分别为75%和35.7%,经x2检验P<0.01,差异有高度显著性。结论MEBO配合微波治疗可明显提高宫颈糜烂临床治疗效果。     

奥平栓联合微波治疗宫颈糜烂的临床体会

目的:探索不同类型宫颈糜烂患者适宜的治疗方法。方法:2004年10月至2008年5月我院将729例宫颈糜烂患者(单纯型140例,颗粒型235例,乳头型354例)随机分成3组,分别采用奥平栓、微波进行治疗,观察和比较其疗效和副反应。结果:奥平栓对单纯型宫颈糜烂的治疗率显著优于颗粒型和乳头型(P<0.05,P<0.01);微波对单纯型宫颈糜烂的治疗率显著优于颗粒型及乳头型(P<0.01),奥平栓加微波对颗粒型治愈率同其他两组差异无显著性意义(P>0.05),而对乳头型宫颈糜烂的治愈率在3种疗法中最高(P<0.01)。副反应以奥平栓最少。结论:单纯型及乳头型宫颈糜烂以奥平栓加微波治疗效果最佳。     

致康胶囊治疗宫颈糜烂微波术后阴道出血121例

目的:观察和评价致康胶囊对宫颈糜烂微波治疗后阴道出血和排液的临床疗效。方法:治疗组61例宫颈局部使用致康胶囊药粉(三七、人参、黄连、白及、血竭等),对照组60例宫颈局部使用云南白药,两组疗程均为3~5d。结果:两组对宫颈糜烂微波治疗后阴道出血的总有效率分别为95.00%、93.33%,疗效无显著性差异(P>0.05);两组对宫颈糜烂微波治疗后阴道排液的有效率分别为83.56%、55.00%,疗效有显著性差异(P<0.05)。结论:致康胶囊能减少宫颈糜烂微波治疗后阴道出血和排液,有促进组织修复、消肿生肌的功效。     

珍珠散协同爱宝疗治疗重度宫颈糜烂的临床疗效与药物经济学研究

目的观察中药珍珠散协同爱宝疗浓缩液治疗重度宫颈糜烂临床疗效和药物经济学效益。方法将有生育要求的Ⅲ度宫颈糜烂患者111例随机分为治疗组和对照组,治疗组用中药珍珠散联合爱宝疗浓缩液治疗,对照组则单用爱宝疗浓缩液治疗,均每3d治疗一次。45d后,比较两组疗效、疗程及治疗费用。结果治疗组治愈率明显高于对照组(67.9%vs36.4%),差异有统计学意义(P<0.05)。治疗组费用明显低于对照组[(371.6±138.4)vs(483.6±36.6)]元(P<0.01)。治疗组治疗时间比对照组显著缩短[(32.4±12.1)vs(44.0±3.3)]d(P<0.01)。治疗组中提前结束治疗患者多于对照组(35/56vs6/55,P<0.05)。治疗组与对照组均未见副作用发生。结论珍珠散协同爱宝疗浓缩液治疗重度宫颈糜烂疗效好,药物经济学效益高,值得临床推广。     

Anti-Corrosion Performance of Migratory Corrosion Inhibitors on Reinforced Concrete Exposed to Varying Degrees of Chloride Erosion

This study investigated the anti-corrosion performance of commercial amino alcohol migratory corrosion inhibitors (MCIs) on concrete that underwent varying degrees of chloride erosion. Electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PD), scanning electron microscopy, and energy dispersive spectroscopy (SEM-EDS) analyses were performed to study the anti-corrosion performance and mechanism of the MCIs on the steel bars. The results indicated that the corrosion resistance of the steel bars in concrete was significantly improved by coating with the MCIs, and the earlier the specimens were coated with the MCIs, the higher the anti-corrosion efficiency. The anti-corrosion efficiency was 55.35% when the MCIs coating was applied before chloride erosion; however, the anti-corrosion efficiency decreased to 3.40% when the MCIs coating was applied after the ninth drying–wetting cycle. The improvement in corrosion resistance of the steel bar in concrete coated with MCIs was due to the protective MCIs-molecule film that formed on the steel bar surfaces, and the oxidative dissolution of iron at the anode was effectively inhibited by the MCIs coating.