玻璃酸钠与Kenacort-A联合治疗膝骨关节炎合并滑膜炎临床观察

目的探讨玻璃酸钠(SH)联合肾上腺皮质激素类药Kenacort-A关节腔内注射治疗膝骨关节炎(OA)合并滑膜炎(SY)的临床疗效。方法选膝OA合并SY患者205例,随机分为单纯用药组(100例)和联合用药组(105例),单纯用药组给予SH关节腔内注射,联合用药组给予AH+Kenacor-A关节腔内注射。结果联合用药组的起效时间及疗效明显优于单纯用药组。结论SH联合Kenacort-A治疗膝OA合并SY,疗效快,可提高临床治疗效果。     

消定膏治疗膝关节创伤性滑膜炎的临床疗效

目的:观察消定膏治疗膝关节创伤性滑膜炎的疗效.方法:将80例膝关节创伤性滑膜炎患者随机分为治疗组(40例)和对照组(40例).治疗组采用消定膏外搽患处,48小时换药1次,4次为1个疗程;对照组采用双氯芬酸乳胶剂4 g外搽患处,4次/d,20 min/次,1个疗程后观察2组患者的疗效和不良反应.结果:2种方法的止痛效果间...     

膝关节慢性滑膜炎的CT研究

目的；探讨膝关节慢性滑膜炎CT表现为分型。方法：回顾性分析关节镜或手术证实或手术证实的89例和随访证实的178例膝关节慢性滑膜炎。结果：根据CT表现将滑膜炎分为4型：皱壁增生型153例（197关节），积液型60例（89关节），单纯囊肿型19例（19关节），混合型35例（50关节）。40岁以上患者膝关节均伴有不同程度的骨质增生、关节退行性变，退行性变的程度与滑膜炎的类型无相关性。结论：CT检查诊断膝关节慢性滑膜炎是较为可靠的方法，可直观关节内皱襞增生、积液以及囊肿形成的征象。积液型要与感染性关节炎鉴别。     

针刀配合中药内服治疗慢性膝关节滑膜炎62例

通过针刀配合中药内服治疗62例慢性膝关节滑膜炎,取得良好效果,总有效率达到95.16%,达到标本兼治的目的。     

Power Doppler sonography in the diagnosis of hemophilic synovitis – a promising tool

Summary. Background: Recurrent hemarthroses in hemophilia results in synovitis and joint arthropathy. Primary prophylaxis when universally instituted at current doses can prevent joint deterioration but is expensive. Alternatively, the selective implementation of prophylaxis would require a more sensitive tool for detecting synovitis than possible with clinical surveillance or plain radiographs. Magnetic resonance imaging (MRI) is such a tool and is utilized for the evaluation of hemophilic joint disease (HJD). However, it is expensive, and requires sedation in younger children precluding its utility for monitoring of synovitis. Ultrasonography (USG) with power Doppler (USG‐PDS) has been utilized to detect and quantitate synovial vascularity in other arthritides and could provide an equally effective but less costly tool for HJD, particularly in children who would not require sedation. Objectives: To determine whether USG‐PDS is comparable to MRI in the evaluation of hemophilic synovitis. Patients: A prospective cohort of 31 subjects including 33 joints (knees, elbows, ankles) underwent dynamic contrast enhanced (DCE)‐MRI and USG‐PDS. Results: USG‐PDS measurements of synovial thickness(r = 0.70, P < 0.0001) and synovial vascularity (r = 0.73, P < 0.0001) correlated strongly with those obtained with DCE‐MRI. A cutoff of PDS intensity of 1.3 decibels (dB) per mm² was found to yield a sensitivity of 100% and a specificity of 94.1% in 17 joints with/without a history of hemarthroses. Pettersson radiographic scores correlated significantly with synovial thickness in adults but not children. Conclusions: Our data suggest that USG‐PDS may be an inexpensive and easily implemented imaging tool for detecting hemophilic synovitis and could be useful in tailoring effective prophylaxis.     

The treatment of intra-articular synovitis by the use of chemical and radioactive substances

As the Chairperson of the session relating the intra-articular use of chemical and radioactive substances it would seem appropriate to give credit to those who contributed to the recent supplement of our Journal Haemophilia. I have extracted key sentences and concepts from the contributed articles. All the papers can be found in Haemophilia, Volume 7, Supplement 2, July 2001. The title, authors and page numbers are provided [1].     

Mechanistic immunological based classification of rheumatoid arthritis

The classical autoimmunity paradigm in rheumatoid arthritis (RA) is strongly supported by immunogenetics suggesting follicular helper T-cell responses driving high titre specific autoantibodies that pre-dates disease onset. Using the immunological disease continuum model of inflammation against self with “pure” adaptive and innate immune disease at opposite boundaries, we propose a novel immune mechanistic classification describing the heterogeneity within RA. Mutations or SNPs in autoinflammatory genes including MEFV and NOD2 are linked to seronegative RA phenotypes including some so called palindromic RA cases. However, just as innate and adaptive immunity are closely functionally integrated, some ACPA+ RA cases have superimposed “autoinflammatory” features including abrupt onset attacks, severe attacks, self-limiting attacks, relevant autoinflammatory mutations or SNPs and therapeutic responses to autoinflammatory pathway therapies including colchicine and IL-1 pathway blockade. An emergent feature from this classification that non-destructive RA phenotypes, both innate and adaptive, have disease epicentres situated in the extracapsular tissues. This mixed innate and adaptive immunopathogenesis may be the key to understanding severe disease flares, resistant disease subsets that are unresponsive to standard therapy and for therapies that target the autoinflammatory component of disease that are not currently considered by expert therapeutic recommendations.     

血友病性慢性滑膜炎的物理治疗

目的探讨运用物理治疗的方法治疗血友病性慢性滑膜炎。方法10例诊断为血友病性慢性滑膜炎的患者接受为期4周的综合物理治疗,比较治疗前后疼痛、关节肿胀程度和肌肉萎缩程度的变化。结果疼痛、关节肿胀治疗前后相比有显著差异(P<0.01),肌肉萎缩治疗前后差异不显著(P>0.05)。结论综合物理治疗对血友病性慢性滑膜炎的疼痛和关节肿胀有显著缓解作用,而肌肉萎缩的改善需要更长时间的训练。     

Intramuscular diffuse-type giant cell tumor within the hamstring muscle

Diffuse-type giant cell tumor (D-TGCT) is known as a synonym for pigmented villonodular synovitis (PVS), a condition usually found in the large joints. We report an extremely rare case of D-TGCT which was located within the hamstring muscle. The lesion was an incidental finding in a 62-year-old man who underwent positron emission tomography (PET) as part of a staging evaluation for gastric cancer. The lesion was resected. There has been neither metastasis nor recurrence during the 6-month period since resection. This case demonstrates that PVS/D-TGCT may have a high SUV on PET imaging, and for this reason PET may be useful for detecting both the tumor and any recurrence.     

Foreign-body reaction to the Artelon CMC joint spacer: case report

The Artelon CMC spacer (Small Bone Innovations, Inc., Morrisville, PA) is a relatively new device that was developed for the treatment of basal joint arthritis. It is composed of a biodegradable polycaprolactone-based polyurethane urea that acts to resurface the distal part of the trapezium and stabilize the trapeziometacarpal joint by augmenting the joint capsule. This is a case report of a foreign-body tissue reaction to the Artelon CMC spacer.