全文获取类型
收费全文 | 9193篇 |
免费 | 760篇 |
国内免费 | 290篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 169篇 |
妇产科学 | 61篇 |
基础医学 | 1019篇 |
口腔科学 | 343篇 |
临床医学 | 703篇 |
内科学 | 1306篇 |
皮肤病学 | 166篇 |
神经病学 | 1147篇 |
特种医学 | 1648篇 |
外科学 | 630篇 |
综合类 | 640篇 |
预防医学 | 215篇 |
眼科学 | 61篇 |
药学 | 1412篇 |
中国医学 | 455篇 |
肿瘤学 | 246篇 |
出版年
2024年 | 12篇 |
2023年 | 103篇 |
2022年 | 345篇 |
2021年 | 455篇 |
2020年 | 230篇 |
2019年 | 274篇 |
2018年 | 306篇 |
2017年 | 311篇 |
2016年 | 350篇 |
2015年 | 403篇 |
2014年 | 627篇 |
2013年 | 599篇 |
2012年 | 568篇 |
2011年 | 673篇 |
2010年 | 568篇 |
2009年 | 531篇 |
2008年 | 522篇 |
2007年 | 437篇 |
2006年 | 390篇 |
2005年 | 404篇 |
2004年 | 302篇 |
2003年 | 261篇 |
2002年 | 210篇 |
2001年 | 178篇 |
2000年 | 135篇 |
1999年 | 113篇 |
1998年 | 103篇 |
1997年 | 112篇 |
1996年 | 110篇 |
1995年 | 114篇 |
1994年 | 115篇 |
1993年 | 95篇 |
1992年 | 59篇 |
1991年 | 34篇 |
1990年 | 38篇 |
1989年 | 22篇 |
1988年 | 22篇 |
1987年 | 18篇 |
1986年 | 12篇 |
1985年 | 22篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 9篇 |
1981年 | 9篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
81.
82.
83.
Reliability of erector spinae oxygenation and blood volume responses using near-infrared spectroscopy in healthy males 总被引:1,自引:1,他引:1
The purpose of this investigation was to (1) describe the trends in oxygenation (OXY) and blood volume (BV) of the right and left paraspinal muscles during the Biering-Sorensen muscle endurance (BSME) test using near infrared spectroscopy (NIRS), and (2) assess the test-retest reliability of OXY and BV changes during the BSME in healthy males. Seventeen healthy males [age=28.4 (9.8) years, height=1.75 (0.05) m, body mass=82.7 (9.1) kg; mean (SD)] completed two BSME trials within 1 week. NIRS probes were placed bilaterally at lumbar 3. The test was performed with the subject in the prone position using the following protocol: 2 min baseline, BSME, and 4 min recovery. The delta and range values of OXY and BV were used for analysis. Acceptable intra-class correlations were observed for endurance time and all the NIRS variables at the point of fatigue and at each 10% segment of the BSME during the two trials. Bland-Altman plots confirmed the reproducibility of the bilateral NIRS responses of the paravertebral muscles. The BV responses were more reliable than the OXY responses during the two trials. The OXY and BV responses of the paravertebral muscles during static contractions can be measured reliably using NIRS. Future studies should focus primarily on BV for analysis. 相似文献
84.
Masayuki Takeda Yasushi Katayama Toshiki Tsutsui Hitoshi Takahashi Kazuhide Saito Shotaro Sato Tatsuhiko Yuasa Takeo Kuwabara 《Urological research》1993,21(3):193-197
Summary
31P nuclear magnetic resonance (NMR) spectroscopy of the in situ rat kidney was performed by a surface coil method, and the effects of ischemia and furosemide infusion were assessed.31P NMR spectra of the kidney subjected to 30 min of ischemia returned completely to the pre-ischemic level after 60 min of reperfusion. But the31P NMR spectra after 60 min of ischemia did not recover, even after 120 min of reperfusion. Levels of -ATP and inorganic phosphate (Pi) decreased and the chemical shift of Pi increased after intravenous infusion of furosemide. This increase in chemical shift might signal an alkalotic change in intracellular pH. Furosemide infusion prior to ischemia is thought to protect the kidney from injury induced by 60 min of warm ischemia. The chemical shift of Pi returned to the pre-ischemic level earlier than -ATP and Pi. In conclusion, according to the findings of31P NMR spectroscopy, furosemide infusion prior to ischemia may be effective in protecting the kidney against ischemic injury. But the change in Pi peak and the causes of the dissociation of Pi and -ATP should be examined further. 相似文献
85.
Kurata M 《Journal of anesthesia》1993,7(3):325-333
31P and 23Na nuclear magnetic resonance (NMR) spectroscopy was employed to study the dynamic changes in intracellular high-energy phosphates and sodium during 15min of forebrain ischemia and recirculation in in vivo rat brain. In the presence of the shift reagent Dysprosium triethylenetetramine-N,N,N,N,N,N-hexaacetic and [Dy(TTHA)], the sodium peak separated into two peaks, unshifted and shifted. During 15min of ischemia, the unshifted sodium peak decreased and the shifted sodium peak increased. With recirculation, the unshifted and the shifted sodium peaks returned to the preischemia level within 10min, but the shifted one increased during 30–60min. Intracellular high-energy phosphates and intracellular pH (pHi) decreased during 15min of ischemia and returned to the preischemia levels within 20min of recirculation. We conclude that the decrease in unshifted sodium peak during ischemia is due to the decrease in subarachnoid sodium and the cellular influx of interstitial sodium would be minimum. The increase in shifted sodium peak during ischemia is considered to be due to the dilatation of cerebral blood vessels and the increase in interstitial sodium which was transported from subarachnoid space.(Kurata M: 31P and 23Na nuclear magnetic resonance study on forebrain ischemia in rats with shift reagent Dy(TTHA). J Anesth 7: 325–333, 1993) 相似文献
86.
Jonas G. Miller Mahnoor Hyat Susan B. Perlman Ronald J. Wong Gary M. Shaw David K. Stevenson Ian H. Gotlib 《Developmental psychobiology》2023,65(1):e22351
Exposure to adversity is a well-documented risk factor for cognitive, behavioral, and mental health problems. In fact, the consequences of adversity may be intergenerational. A growing body of research suggests that maternal exposures to adversity, including those prior to childbirth, are associated with offspring biobehavioral development. In a sample of 36 mothers and their preschool-age children (mean child age = 4.21 ± 0.92 years), we used functional near-infrared spectroscopy to replicate and extend this work to include brain activation during inhibitory control in young children. We found that measures of maternal exposure to adversity, including cumulative, childhood, and preconception exposures, were significantly and positively associated with activation in the right frontopolar prefrontal cortex (PFC) and in the left temporal and parietal clusters during inhibitory control. In addition, and consistent with previous findings, children's increased negative affect and decreased effortful control were associated with increased right PFC activation during inhibitory control. These findings provide preliminary evidence that maternal and dispositional risk factors are linked to alterations in PFC functioning during the preschool years. Children of mothers with a history of exposure to adversity, as well as children who are less temperamentally regulated, may require increased neural resources to meet the cognitive demands of inhibitory control. 相似文献
87.
88.
Photoacoustic Fourier transform infrared (PA-FT-IR) depth profiling spectra of the enamel of an intact human tooth are obtained in a completely nondestructive fashion. The compositional and structural changes in the tissue are probed from the enamel surface to a depth of about 200 m. These changes reflect the state of tissue development. The subsurface carbonate gradient in the enamel could be observed over the range of about 10–100 m. The carbonate-to-phosphate ratio increases in the depth profile. The depth profile also reveals changes in the substitutional distribution of carbonate ions. Type A carbonates (hydroxyl substituted) increase relative to type B carbonates (phosphate substituted) with increasing thermal diffusion length. In addition to the changes in the carbonate ion distribution and content, the PA-FT-IR depth profile clearly indicates a dramatic increase in the protein content relative to the phosphate content with increased depth. The changes in the carbonate content and distribution, along with the changes in the protein content, may be responsible for the changes observed in the apatitic structure in the depth profile of the enamel. 相似文献
89.
Durrer Carlo Irache Juan Manuel Puisieux Francis Duchêne Dominique Ponchel Gilles 《Pharmaceutical research》1994,11(5):674-679
A Fourier transform infrared spectroscopy/attenuated total reflection technique for direct quantification of adsorbed poly(styrene) latexes on rat intestinal mucosa was developed for deposited latex amounts up to 1.5 g/m2. The method agreed well with another dosage assay of adsorbed particles by turbidimetry after denaturation of the mucus. Adsorption kinetics were made under static conditions at latex concentrations of 4 g/L in physiological saline. Ninety percent of equilibrium was reached after 10 min for a particle size of 230 nm, 20 min for a size of 320 nm, and 30 min for a size of 670 nm. The plateaus were between 0.6 and 0.9 g/m2 (adsorbed mass per apparent surface of mucosa). The first phase of the kinetics was theoretically approached by a diffusion model in the suspension medium. Mucosa from rat jejunum and ileum could be considered as a homogeneous biological model for latex adsorption. 相似文献
90.
B. Barbiroli R. Medori H. -J. Tritschler T. Klopstock P. Seibel H. Reichmann S. Iotti R. Lodi P. Zaniol 《Journal of neurology》1995,242(7):472-477
A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid. Before treatment a decreased phosphocreatine (PCr) content was found in the occipital lobes, accompanied by normal inorganic phosphate (Pi) level and cytosolic pH. Based on these findings, we found a high cytosolic adenosine diphosphate concentration [ADP] and high relative rate of energy metabolism together with a low phosphorylation potential. Muscle MRS showed an abnormal work-energy cost transfer function and a low rate of PCr recovery during the post-exercise period. All of these findings indicated a deficit of mitochondrial function in both brain and muscle. Treatment with 600 mg lipoic acid daily for 1 month resulted in a 55% increase of brain [PCr], 72% increase of phosphorylation potential, and a decrease of calculated [ADP] and rate of energy metabolism. After 7 months of treatment MRS data and mitochondrial function had improved further. Treatment with lipoate also led to a 64% increase in the initial slope of the work-energy cost transfer function in the working calf muscle and worsened the rate of PCr resynthesis during recovery. The patient reported subjective improvement of general conditions and muscle performance after therapy. Our results indicate that treatment with lipoate caused a relevant increase in levels of energy available in brain and skeletal muscle during exercise. 相似文献