四逆加黄连方联合无创正压通气对急诊心力衰竭血清NT-proBNP、Galectin-3、CK-MB及氧动力学指标的影响

目的 观察四逆加黄连方联合无创正压通气用于急性心力衰竭患者疗效的影响,及其对患者Galectin-3、NT-proBNP、CK-MB及氧动力学指标的影响.方法 选取2017年1月—2020年5月于邯郸明仁医院治疗的急性心力衰竭患者162例,按照随机数字表法分为对照组和观察组,每组81例.对照组患者给予无创呼吸机辅助通气...     

急性脑梗死始发状态阴虚阳亢证与血浆内皮素的关系探讨

目的 探讨中风病阴虚阳亢证与血浆内皮素（ET）水平的关系,以从微观角度寻求中风病证候的辨证依据。方法 应用证候辨证量化诊断方法对151例经CT或MRI确诊为缺血性中风始发态的患者进行量化评分,将其分为阴虚阳亢证和非阴虚阳亢证两组,同时用放射免疫分析（RIA）法测定本病患者及60例健康体检者的血浆ET含节,并进行对照。结果 两组ET含量均升高,与健康人组比较具有显著差异;阴虚阳亢证组ET含量较非阴虚阳亢证组高,两组比较有统计学意义。结论缺血性中风阴虚阳亢证与ET有密切关系,可作为该病早期微观辨证分型参考指标之一。     

"心寄窍于耳"研究进展

通过对近10年来有关“心寄窍于耳”的临床报道、实验研究及生理病理等方面进行了归纳、整理、分析,综述“心寄窍于耳”的研究进展,对“心寄窍于耳”的理论进行了较为科学的探讨,旨在论证“心寄窍于耳”理论的科学性,深入探求心与耳的关系。     

Combined Hyperactive Dysfunction Syndrome of the Cranial Nerves

Objective

Combined hyperative dysfunction syndrome (HDS) defined as the combination of HDSs such as trigeminal neuralgia (TN), hemifacial spasm (HFS) and glossopharyngeal neuralgia (GPN), which may or may not occur simultaneously on one or both sides. We reviewed patients with combined HDS and demonstrated their demographic characteristics by comparing them with those of patients with a single HDS.

Methods

Between October 1994 and February 2006, we retrospectively studied a series of 1,720 patients who suffered from HDS and found 51 patients with combined HDSs. We analyzed several independent variables in order to evaluate the prevalence and etiologic factors of combined HDS.

Results

The combined HDS group accounted for 51 of 1,720 (2.97%) patients with HDS; 27 cases of bilateral HFS, 10 cases of bilateral TN and 14 cases of HFS with TN. Their mean age was 52.1 years (range, 26-79 years). There were 5 men and 46 women. Seven patients had synchronous and 44 patients metachronous onset of HDSs. By comparison of combined and single HDS groups, we found that age and hypertension were closely associated with the prevalence of combined HDS (p < 0.05).

Conclusion

This study revealed that combined HDS was very rare. Hypertension and age might be the most important causative factors to evoke combined HDS.     

温阳降浊汤在肾功能不全患者手术前的应用

目的：分析温阳降浊汤在慢性肾功能不全普通外科患者手术前的作用。方法：对18例患者应用温阳降浊汤进行术前准备,与同期未用温阳降浊汤的病例对比,并分析两组Cr、BUN、Ccr、24h蛋白定量等差异。结果：温阳降浊汤组较对照组在术前肾功能改善方面作用明显,也明显缩短了术后住院时间（P〈0.001）,减少了住院费用（P〈0.001）。结论：温阳降浊汤在用于慢性肾功能不全患者的术前准备中具有显著作用。     

Enhanced apomorphine sensitivity and increased binding of dopamine D2 receptors in nucleus accumbens in prepubertal rats after neonatal blockade of the dopamine D3 receptors by (+)-S14297

The role of dopamine (DA) D3 receptors is controversial in early developmental stages of specially locomotor activity. Past studies have only tested behavioral changes induced by neonatal administration of nonselective dopamine antagonist such as haloperidol or sulpiride in adult rats. We investigated the role of neonatal blockade of DA D3 receptors at (postnatal day, P1 to P12) using the DA D3 receptor antagonist (+)-S14297 on paradigms related to DA behaviors including locomotor activity in novel environment and after administration of the DA nonspecific agonists d-amphetamine, and apomorphine. Additionally, autoradiographic studies were performed to correlate behavioral alterations with DA D1-like, D2-like, and D3 receptors. All studies were performed at two critical ages, prepubertal (P35) and postpubertal (P60). The quantitative autoradiogaphic study revealed increases in the expression of DA D2-like receptor expression in the nucleus accumbens (NAcc) in prepubertal animals that received the DA D3 antagonist (+)-S14297 at neonatal age. In addition, novel environment and apomorphine administration (0.5 mg/kg, s.c.), induced increases of locomotor activity in prepubertal animals that received the DA D3 antagonist (+)-S14297. Autoradiographic and behavioral results suggest that blockade of DA D3 receptors after birth may mediate different neurodevelopmental aspects of the dopaminergic pathway before and after puberty.     

滋水清肝饮加减治疗围绝经期综合征32例

目的:观察滋水清肝饮对围绝经期的临床疗效。方法:按照评分标准将42例患者分为轻度组、中度组和重度组;采用口服滋水清肝饮加减治疗,30d为1个疗程,观察2个疗程后进行比较。结果:重度组治疗前后积分有显著性差异(P<0.01)。结论:滋水清肝饮治疗重度围绝经期效果显著。     

慢性特发性血小板减少性紫癜“治从气阴”

对于慢性特发性血小板减少性紫癜（CITP）的中医理解和治疗目前仍呈百家争鸣之态。通过挖掘总结文献资料和临床实践经验,从＂气阴之辨＂、＂脏腑之辨＂、＂经络之辨＂对CITP治当从＂气阴＂进行了系统阐述。旨在进一步明确对CITP的中医认识,进而指导临床,提高疗效。     

宫颈病变患者HPV基因亚型转阴情况的研究

目的探讨宫颈病变患者HPV基因亚型转阴情况。方法对2010年5月1日至2011年8月30日于济宁医学院附属医院就诊的3224例患者进行HPV分型检测。结果 3224例样本中,检出HPV阳性者892例,其中高危型HPV（16、52、58、53、31、66、68、33、39、18、56、59、45、51、35）676例,低危型HPV（6、11、44、CP8304）216例。高危型HPV16（23.1%）及HPV52（13.1%）感染率较高。通过对复查患者进行统计,发现低危型HPV11转阴率（87.3%）较高,高危型HPV16和52（67.7%,67.4%）次之,HPV58（43.5%）较低。结论鲁西南地区人群HPV感染亚型除16、58、11外,亚型52也较常见。低危型HPV11感染的转阴率较高,且高危型HPV感染也存在一定的转阴率。     

杨洪涛运用麻黄桂枝各半汤治疗慢性肾功能衰竭瘙痒症经验

肺脾肾三脏功能失司,津液代谢异常,致使水湿浊毒内聚,不能从水道排出,脾肾阴阳衰惫,湿浊毒邪浸淫肌肤则致皮肤瘙痒。治疗宜发汗散邪,调和营卫,治当小发其汗,桂枝麻黄各半汤由麻黄汤与桂枝汤各取三分之一合并而成,旨在使桂枝汤调和营卫而不留邪,麻黄汤解表发汗而不伤正。