六神曲质量标准研究

目的：建立六神曲的质量标准。方法：通过全国六神曲处方组成、药物剂量配比、发酵工艺和成品质量研究进行分析。结果：各地标准六神曲药物组成、剂量配比出入较大,发酵工艺不尽相同,成品的质量控制仅凭感官判断,质量较难控制。结论：制定统一的国家标准,确保六神曲临床疗效。     

替代对照品法在镇静安神类药物HPLC快速检验方法中的应用

目的 采用替代对照品法建立镇静安神类药物氯氮卓、马来酸咪达唑仑、硝西泮、艾司唑仑、奥沙西泮、劳拉西泮和阿普唑仑的高效液相色谱快速检验方法。方法 采用Agilent ZORBAX Eclipse Plus C₈色谱柱(4.6 mm×150 mm,5 μm),流动相：0.01 mol·L^-1磷酸二氢钾溶液(pH 2.5)-(甲醇-乙腈1∶1)(57∶43),流速：1.0 mL·min^-1,柱温：30 ℃。采用相对容量因子和紫外光谱相似度双指标进行定性;采用相对校正因子法进行定量分析。结果 在确定的色谱条件下,氯氮?、咪达唑仑、硝西泮、艾司唑仑、奥沙西泮、劳拉西泮和阿普唑仑完全分离;采用紫外光谱相似度和相对容量因子进行定性,结果准确可靠;采用替代对照品法,计算药物的相对校正因子进行含量测定,能有效减少对照品的使用,加快高效液相色谱分析速度。结论 该方法快速、简便、可靠,适用于快速检验镇静安神类药物。     

核磁共振波谱法测定安立生坦对照品的含量

摘 要 目的： 建立测定安立生坦对照品含量的方法。 方法: 采用核磁共振波谱法,使用Bruker AscendTM 400超导核磁共振谱仪,以氘代DMSO为溶剂,在脉冲宽度10.0 μs, 延迟时间5 s和扫描次数16的条件下采集试样氢谱。结果:以化学位移分别为6.16 ppm和6.28 ppm的安立生坦和顺丁烯二酸的氢质子峰作为定量峰,其峰面积比与其质量比的线性回归方程为Y=0.140 7X+0.034 8,相关系数为0.999 4,含量测定重复性试验的RSD为0.2%（n=6）。测得安立生坦对照品的绝对含量为99.9%。结论: 分析结果表明,在没有对照品的情况下,该方法可行,且具有快速、准确、简便的优点。     

Development of Diagnostic Reference Levels Using a Real-Time Radiation Dose Monitoring System at a Cardiovascular Center in Korea

Digital cardiovascular angiography accounts for a major portion of the radiation dose among the examinations performed at cardiovascular centres. However, dose-related information is neither monitored nor recorded systemically. This report concerns the construction of a radiation dose monitoring system based on digital imaging and communications in medicine (DICOM) data and its use at the cardiovascular centre of the University Hospitals in Korea. The dose information was analysed according to DICOM standards for a series of procedures, and the formulation of diagnostic reference levels (DRLs) at our cardiovascular centre represents the first of its kind in Korea. We determined a dose area product (DAP) DRL for coronary angiography of 75.6 Gy cm² and a fluoroscopic time DRL of 318.0 s. The DAP DRL for percutaneous transluminal coronary intervention was 213.3 Gy cm², and the DRL for fluoroscopic time was 1207.5 s.     

Effect of choice of reference equation on analysis of pulmonary function in cystic fibrosis patients

Pulmonary function is an important measure of disease severity and prognosis in cystic fibrosis (CF). It is generally expressed as a percentage of a predicted value, calculated using regression equations derived from a reference population. A number of reference equations are in widespread use. The purposes of this study were to determine: 1) the extent to which, for a given absolute FEV(1) value, percent of predicted (PPFEV(1)) values vary when derived by different reference equations; and 2) whether these differences affect conclusions of longitudinal and cross-sectional analyses. Subjects were all Caucasians 6-18 years old in the 1990 Cystic Fibrosis Foundation Registry. We found clinically important discrepancies in PPFEV(1) when calculated by the methods of Dockery et al. [Am Rev Respir Dis 1983;128:405-412] and Wang et al. [Pediatr Pulmonol 1993;15:75-78] as compared to Knudson et al. [Am Rev Respir Dis 1983;127:725-734] or Polgar and Promadhat [Pulmonary Function Testing in Children 1971; Philadelphia: W.B. Saunders]. In longitudinal analyses, the choice of reference equation resulted in varying apparent rates of decline in FEV(1). For example, among subjects ages 12-14 years in 1990, the decline in PPFEV(1) from 1990-1995 varied between 2-11%, depending on the choice of reference equation. In cross-sectional analyses, the choice of reference equation affected the distribution of subjects classified as having mild, moderate, or severe lung disease. CF physicians should be aware of the impact of choice of reference equation in both clinical care and research.     

鼻内镜下眶下壁骨折修复方式及材料应用研究进展

眼眶骨折是指外力撞击眼部引起面中部多发骨折的外伤,按骨折性质大致可分为：爆裂性眶壁骨折、复合性眶壁骨折、复杂性眶壁骨折;按部位可分为眶下壁骨折、眶内侧壁骨折、眶下壁和眶内侧壁联合骨折,其中以眶下壁骨折最为常见。随着医学技术的进步与发展,手术修复是目前治疗眶下壁骨折最理想的方法,利用鼻内镜联合传统入路或直接经鼻腔入路手术具有可直视眶壁骨折的部位、直接评估伤情及制定手术方案等优势。本文针对眶下壁骨折的诊断、辅助检查、手术指征、鼻内镜修复眼眶骨折的手术术式、术式的优点和缺点及各种修复材料的特点等内容作一综述。     

特应性皮炎临床特点与诊断标准探讨

目的：探讨特应性皮炎的临床特点与诊断标准。方法选择特应性皮炎患者638例,均符合 HR 的相关诊断,统计所有患者对于康田标准的符合率,观察其遗传过敏情况、伴随体征以及嗜酸性粒细胞、血清 IgE情况。结果经过 HR 确诊为特应性皮炎的638例患者中符合康田标准者618例,总符合率为96.87％,符合率随着年龄段的增长而增高。在过敏史中个人过敏史随着年龄增长而发病率增加,家族过敏史中超过12岁者明显增多。在临床症状中干皮症、掌纹症、面部皮炎所占比例最高,乳头湿疹、唇炎、眶下皱褶、白色糠疹所占比例较低。各年龄阶段的患者嗜酸性粒细胞与 IgE 的均值均高于正常值。结论康田标准对于特应性皮炎的诊断标准合理实用。