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目的:探讨维甲酸对自发性高血压大鼠(SHR)心肌、血管平滑肌增殖的影响和肾素-血管紧张素-醛固酮系统(RAS)所起的作用。方法:18只SHR大鼠随机分为全反式维甲酸治疗组、对照组、卡托普利治疗组,每组6只。分别予治疗组和对照组皮下注射全反式维甲酸(ATRA)10mg/Kg体重或溶媒,高血压药物治疗组予卡托普利0.25mg/Kg体重管饲,每天一次,均疗程4周。疗程结束后观察各组SHR大鼠心肌、血管平滑肌(VSMC)增殖细胞核抗原(PCNA)的变化以及心肌ACE-mRNA、ACE2-mRNA的表达。结果:维甲酸治疗组心肌、血管平滑肌增殖细胞核抗原(PCNA)表达显著低于对照组(P<0.01),卡托普利治疗组的PCNA表达也显著低于对照组(P<0.01),但维甲酸治疗组与卡托普利组比较也有显著差异(P<0.01);维甲酸治疗组ACE-mRNA的表达低于卡托普利组及对照组(P<0.01),卡托普利组ACE-mRNA的表达也低于对照组(P<0.01);而维甲酸组ACE2-mRNA的表达则高于对照组及卡托普利组(P<0.01),后两组之间则无显著差异(P>0.05)。结论:维甲酸能抑制SHR模型心肌、血管平滑肌PCNA的表达,并在增加ACE2-mRNA表达的同时减少ACE-mRNA的表达,从而有可能干预增殖性血管疾病的病程。 相似文献
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Philip F. J. Hoyng Nynke de Jong Hans Oosting Jan Stilma 《International ophthalmology》1992,16(2):65-73
Platelet aggregationin vitro, deterioration of visual field defects (VFD) and the prevalence of disc haemorrhages (DH) were assessed in 49 patients with primary open angle glaucoma (POAG) and compared with the findings for 67 individuals with suspected glaucoma (GS) in a seven-year follow-up study (range 5.8 to 8.2 years). The percentage patients with spontaneous platelet aggregation (SPA) was higher for POAG patients with visual field deterioration (60%) than both POAG patients without progressive loss of visual fields (12.5%; P<0.005) and those with suspected glaucoma (22.4%; P<0.005). The occurrence of DH was higher among POAG patients with progressive loss of visual field (28%) compared to the GS group (8.4%; P<0.025) and the group of patients consisting of POAG patients without deterioration of VFD and GS (9.9%; P<0.05). DH also occurred more often in patients with low tension glaucoma (41.6%) than in the remaining POAG patients (13.5%; P<0.05). No relation between the patients with SPA and the patients with DH was observed.Abbreviations NPB
normal platelet behavior
- SPA
spontaneous platelet aggregation
- DH
disc haemorrhage 相似文献
15.
自发性食管破裂的护理 总被引:3,自引:0,他引:3
目的 总结自发性食管破裂患者的护理措施,提高护理水平。方法 在保守及手术治疗的同时,严密观察病情变化,做好心理护理,加强呼吸道、消化道及各种管道的护理。结果 7例患者治愈出院。结论 精心的专业化护理在治疗自发性食管破裂中起重要作用。 相似文献
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A 49-year-old man presented with episodic hypothermia many years after sustaining a contusional brain injury. Brain magnetic resonance imaging demonstrated the destruction of the anterior parts of the corpus callosum without hypothalamic lesions. Nevertheless, delayed hypothalamic dysfunction at the neurotransmitter level is the probable pathophysiological key factor. Clomipramine treatment was beneficial. This case expands the spectrum of Shapiro's syndrome. 相似文献
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食管穿孔和破裂的诊断与治疗 总被引:10,自引:1,他引:9
目的 提高对食管穿孔和破裂的诊断及处理水平。方法 回顾性分析经外科处理的45例食管穿孔或破裂患的临床资料。结果 本组患经胸部平片、胸腔穿刺、上消化道造影及胃镜确诊。15例为自发性食管破裂,6例为医源性穿孔,5例为创伤性穿孔,10例为食管癌并食管支气管瘘,9例为食管憩室并食管支气管瘘。治疗予以食管修补9例;胸腔引流、空肠造瘘9例(其中1例为食管修补失败后改行此手术);食管切除胃食管吻合术12例(其中3例为食管修补失败);胃造瘘术4例;置入食管支架4例;食管支气管瘘切除修补3例;食管瘘口修补并肺叶切除2例;食管胃弓上短路1例,颈部引流2例;放弃治疗3例。治愈25例,好转11例,死亡6例。结论 详细了解病史和进行胸腔穿刺、上消化道造影等检查可帮助诊断。尽早手术闭合瘘口和治疗食管原发病变是治疗的关键。 相似文献
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A. Conforti R. Leone U. Moretti L. Guglielmo G. P. Velo 《Pharmacoepidemiology and drug safety》1995,4(3):129-135
Pharmacovigilance started in Italy in 1965, and from 1987 reporting of ADRs has been mandatory. Doctors have to send the filled forms on suspected ADRs to the Local Health Districts which transmit biannually all the reports to the Health Department. In a Northern Italian Region (Veneto) spontaneous reporting of adverse drug reactions (ADRs) has been studied during the period 1988–1993. This Region contributes a substantial percentage of the total Italian reports. The total number of reports was 3700, most of these (54 per cent) coming from GPs. A great variability in the reporting rate among the 36 districts of Veneto Region (range: 0–8.8 per 10,000 inhabitants per year) and an important under-reporting have been evident. Underreporting is also emphasized by the fact that in 1993 the Veneto doctors who sent at least one report were only 2.7 per cent. On the whole about 35 per cent of reports concerned minor reactions caused by drugs which have a well known toxicological profile. Comparison between reports coming from Veneto and the UK in some cases show a similar safety profile (omeprazole and simvastatin), whereas in other cases (e.g. terfenadine, glafenine, fluoxetine) no correspondence can be found. This article reveals the limits of the actual spontaneous reporting in Italy and suggests some possible measures for improving it. 相似文献
19.
头低位模拟失重状态对前庭功能的影响 总被引:4,自引:1,他引:3
为研究头低位模拟失重对运动病症状、垂直视动眼震(VOKN)及体液重新分配的影响,在头低位-10°的模拟失重状态下,采用大视野的垂直视动刺激,观察18名正常人的运动病症状、VOKN、激素(AVP、VIP、CORT、ALDO)的反应特点。结果表明,头低位-10°状态下的大视野垂直视动刺激可以诱发出明显的运动病症状,头低位-10°的垂直视动刺激比坐位更容易诱发运动病。坐位状态VOKN慢相速度有明显的方向性不对称,敏感组VOKN方向性不对称有显著差异(P<0.05)。头低位-10°时VOKN的不对称现象不明显,向下方向运动的VOKN慢相速度显著增加。分析指出,头低位-10°状态下垂直视动刺激比坐位和秋千刺激的贡献率大。尿中CORT(皮质醇)在秋千和头低位的垂直视动刺激前后有显著性增加。提示:大视野的垂直视动刺激与头低位-10°两种刺激的结合可能成为预测空间运动病的方法之一. 相似文献
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Hajime Kazamatsuri M.D. Tetsuya Hirose M.D. Osamu Kanno M.D. Nobumasa Kato M.D. Hiromoto Yasuda 《Psychiatry and clinical neurosciences》1994,48(4):869-879
Abstract: Two autopsied female sibling cases of sudanophilic leukodystrophy are reported. Case A and case B were the second and third of seven siblings, and a sister and a brother died from severe progressive neurological disease with similar symptoms. Consanguineous marriages were noted in the family of both cases through the past three generations. Case A gradually developed intellectual deterioration and tetraplegia at the age of 29, progressed to akinetic mutism within one year and thereafter survived for 14 years. Neuropathologically, a severe atrophy and degeneration were noted in the white matter of the whole cerebrum, sparing the subcortical U-fibers. Myelin and axons were severely damaged with peripheral astrocytic gliosis. Case B developed similar clinical symptoms at the age of 20 and survived for 7 years in the state of akinetic mutism. Similar postmortem findings as those of case A were found in the white matter of the cerebrum with formation of sudanophilic breakdown products and with thick fibrillary gliosis. The pyramidal tract was completely degenerated. There was no accumulation of abnormal lipid in the brains of both cases. 相似文献