全文获取类型
收费全文 | 1751篇 |
免费 | 171篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 11篇 |
妇产科学 | 4篇 |
基础医学 | 327篇 |
口腔科学 | 14篇 |
临床医学 | 170篇 |
内科学 | 209篇 |
皮肤病学 | 17篇 |
神经病学 | 263篇 |
特种医学 | 218篇 |
外科学 | 96篇 |
综合类 | 103篇 |
预防医学 | 35篇 |
眼科学 | 211篇 |
药学 | 121篇 |
中国医学 | 55篇 |
肿瘤学 | 46篇 |
出版年
2024年 | 7篇 |
2023年 | 21篇 |
2022年 | 47篇 |
2021年 | 79篇 |
2020年 | 53篇 |
2019年 | 55篇 |
2018年 | 60篇 |
2017年 | 72篇 |
2016年 | 76篇 |
2015年 | 62篇 |
2014年 | 102篇 |
2013年 | 127篇 |
2012年 | 82篇 |
2011年 | 69篇 |
2010年 | 63篇 |
2009年 | 63篇 |
2008年 | 71篇 |
2007年 | 61篇 |
2006年 | 78篇 |
2005年 | 53篇 |
2004年 | 58篇 |
2003年 | 58篇 |
2002年 | 33篇 |
2001年 | 47篇 |
2000年 | 45篇 |
1999年 | 29篇 |
1998年 | 56篇 |
1997年 | 44篇 |
1996年 | 46篇 |
1995年 | 35篇 |
1994年 | 24篇 |
1993年 | 27篇 |
1992年 | 16篇 |
1991年 | 14篇 |
1990年 | 9篇 |
1989年 | 11篇 |
1988年 | 7篇 |
1987年 | 8篇 |
1986年 | 11篇 |
1985年 | 16篇 |
1984年 | 9篇 |
1983年 | 4篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1973年 | 1篇 |
排序方式: 共有1951条查询结果,搜索用时 15 毫秒
21.
Effect of relaxation training on cardiac parasympathetic tone 总被引:8,自引:0,他引:8
To examine the hypothesis that the relaxation response is associated with an increase in cardiac parasympathetic tone, the frequency components of heart rate variability during relaxation training were investigated in 16 college students. Electrocardiograms and pneumograms were recorded during a 5-min baseline period followed by three successive 5-min sessions of the autogenic training (relaxation) or by the same periods of quiet rest (control), while subjects breathed synchronously with a visual pacemaker (0.25 Hz). Although neither the magnitude nor the frequeney of respiration showed a significant difference between relaxation and control, the amplitude of the high-frequency component of heart rate variability increased only during relaxation (p= .008). There was no significant difference in the ratio of the low-frequency (0.04–0.15 Hz) to the high-frequency amplitudes. The increased high-frequency amplitude without changes in the respiratory parameters indicates enhanced cardiac parasympathetic tone. Thus, our results support the initial hypothesis of this study. Enhanced cardiac parasympathetic tone may explain an important mechanism underlying the beneficial effect of the relaxation response. 相似文献
22.
Roky R Chapotot F Benchekroun MT Benaji B Hakkou F Elkhalifi H Buguet A 《Journal of sleep research》2003,12(2):95-101
During the lunar month of Ramadan, Muslims abstain from eating, drinking and smoking from sunrise to sunset. We reported previously that Ramadan provokes a shortening in nocturnal total sleep time by 40 min, an increase in sleep latency, and a decrease in slow-wave sleep (SWS) and rapid eye movement (REM) sleep duration during Ramadan. During the same study, the effects of Ramadan intermittent fasting on daytime sleepiness were also investigated in eight healthy young male subjects using a quantitative waking electroencephalograph (EEG) analysis following the multiple sleep latency test (MSLT) procedure. This procedure was combined with subjective alertness and mood ratings and was conducted during four successive experimental sessions: (1) baseline (BL) 15 days before Ramadan, (2) beginning of Ramadan (R11) on the 11th day of Ramadan, (3) end of Ramadan (R25) on the 25th day of Ramadan, (4) recovery 2 weeks after Ramadan (AR). During each session, four 20-min nap opportunities (MSLTs) were given at 10:00, 12:00, 14:00 and 16:00 h and were preceded by rectal temperature readings. Nocturnal sleep was recorded before each daytime session. Subjective daytime alertness did not change in R25 but decreased in R11 at 12:00 h, and subjective mood decreased at 16:00 h, both in R11 and R25. During the MSLT, mean sleep latency decreased by an average of 2 min in R11 (especially at 10:00 and 16:00 h) and 6 min in R25 (especially at 10:00 and 12:00 h) compared with BL. There was an increase in the daily mean of waking EEG absolute power in the theta (5.5-8.5 Hz) frequency band. Significant correlations were found between sleep latency during the MSLT and the waking EEG absolute power of the fast alpha (10.5-12.5 Hz), sigma (11.5-15.5 Hz) and beta (12.5-30 Hz) frequency bands. Sleep latency was also related to rectal temperature. In conclusion, Ramadan diurnal fasting induced an increase in subjective and objective daytime sleepiness associated with changes in diurnal rectal temperature. 相似文献
23.
Evening administration of melatonin and bright light: Interactions on the EEG during sleep and wakefulness 总被引:1,自引:0,他引:1
CHRISTIAN CAJOCHEN KURT KRÄUCHI KONSTANTIN V. DANILENKO & ANNA WIRZ-JUSTICE 《Journal of sleep research》1998,7(3):145-157
Both the pineal hormone melatonin and light exposure are considered to play a major role in the circadian regulation of sleep. In a placebo- controlled balanced cross-over design, we investigated the acute effects of exogenous melatonin (5 mg p.o. at 20.40 hours) with or without a 3-h bright light exposure (5000 lux from 21.00 hours–24.00 hours) on subjective sleepiness, internal sleep structure and EEG power density during sleep and wakefulness in healthy young men. The acute effects of melatonin, bright light and their interaction were measured on the first day (treatment day), possible circadian phase shifts were assessed on the post-treatment day. On the treatment day, the evening rise in subjective sleepiness was accelerated after melatonin and protracted during bright light exposure. These effects were also reflected in specific changes of EEG power density in the theta/alpha range during wakefulness. Melatonin shortened and bright light increased sleep latency. REMS latency was reduced after melatonin administration but bright light had no effect. Slow-wave sleep and slow-wave activity during the first non-rapid eye movement (NREMS) episode were suppressed after melatonin administration and rebounded in the second NREMS episode, independent of whether light was co-administered or not. Self rated sleep quality was better after melatonin administration whereas the awakening process was rated as more difficult after bright light. On the post-treatment day after evening bright light, the rise in sleepiness and the onset of sleep were delayed, independent of whether melatonin was co-administered or not. Thus, although acute bright light and melatonin administration affected subjective sleepiness, internal sleep structure and EEG power density during sleep and wakefulness in a additive manner, the phase shifting effect of a single evening bright light exposure could not be blocked by exogenous melatonin 相似文献
24.
The effects of age and gender on sleep EEG power spectral density in the middle years of life (ages 20-60 years old) 总被引:2,自引:0,他引:2
The effects of age and gender on sleep EEG power spectral density were assessed in a group of 100 subjects aged 20 to 60 years. We propose a new statistical strategy (mixed-model using fixed-knot regression splines) to analyze quantitative EEG measures. The effect of gender varied according to frequency, but no interactions emerged between age and gender, suggesting that the aging process does not differentially influence men and women. Women had higher power density than men in delta, theta, low alpha, and high spindle frequency range. The effect of age varied according to frequency and across the night. The decrease in power with age was not restricted to slow-wave activity, but also included theta and sigma activity. With increasing age, the attenuation over the night in power density between 1.25 and 8.00 Hz diminished, and the rise in power between 12.25 and 14.00 Hz across the night decreased. Increasing age was associated with higher power in the beta range. These results suggest that increasing age may be related to an attenuation of homeostatic sleep pressure and to an increase in cortical activation during sleep. 相似文献
25.
In this study, the relationship between physiological arousal, as indexed by heart rate variability, was examined in boys with fragile X syndrome (FXS) and typically developing boys matched on chronological age. In addition, the relationship of heart activity to clinical and molecular factors in the group of boys with FXS was examined. Results suggest that boys with FXS have higher levels of heart activity during the passive phases, as reflected in shorter heart periods. This high level of heart activity appears to be due to increased sympathetic activity and reduced parasympathetic activity. Boys with FXS did not display the expected patterns of heart activity in response to phases of increasing challenge, and sympathetic and parasympathetic systems did not appear coordinated in these boys with FXS. Clinical factors may be related to neural regulation of heart activity while molecular factors do not appear to be. 相似文献
26.
Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous infusion 总被引:2,自引:0,他引:2
Peter P. C. Tan Ming-Hwang Shyr Chen-Hsein Yang Terry B. J. Kuo Wynn H. T. Pan Samuel H. H. Chan 《Neuroscience letters》1993,160(2):205-208
Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, , β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography. 相似文献
27.
Stefanie Kreutmair Susanne Unger Nicolás Gonzalo Núñez Florian Ingelfinger Chiara Alberti Donatella De Feo Sinduya Krishnarajah Manuel Kauffmann Ekaterina Friebel Sepideh Babaei Benjamin Gaborit Mirjam Lutz Nicole Puertas Jurado Nisar P. Malek Siri Goepel Peter Rosenberger Helene A. Häberle Ikram Ayoub Burkhard Becher 《Immunity》2021,54(7):1578-1593.e5
28.
Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans 总被引:3,自引:3,他引:3
SUMMARY The hypothesis that local activation of brain regions during wakefulness affects the EEG recorded from these regions during sleep was tested by applying vibratory stimuli to one hand prior to sleep. Eight subjects slept in the laboratory for five consecutive nights. During a 6-h period prior to night 3, either the left or the right hand was vibrated intermittently (20 min on-8 min off), while prior to night 5 the same treatment was applied to the contralateral hand. The sleep EEG was recorded from frontal, central, parietal and occipital derivations and subjected to spectral analysis. The interhemispheric asymmetry index (IAI) was calculated for spectral power in nonREM sleep in the frequency range 0.25-25.0 Hz for 0.5-Hz or 1-Hz bins. In the first hour of sleep following right-hand stimulation, the IAI of the central derivation was increased relative to baseline, which corresponds to a shift of power towards the left hemisphere. This effect was most prominent in the delta range, was limited to the first hour of sleep and was restricted to the central derivation situated over the somatosensory cortex. No significant changes were observed following left-hand stimulation. Although the effect was small, it is consistent with the hypothesis that the activation of specific neuronal populations during wakefulness may have repercussions on their electrical activity pattern during subsequent sleep. 相似文献
29.
SUMMARY Five male subjects were exposed to a single 2-h period of bright (2500 lux) or dim (<100 lux) light prior to sleep on two consecutive nights. The two conditions were repeated the following week in opposite order. Bright light significantly suppressed salivary melatonin and raised rectal temperature 0.3°C (which remained elevated during the first 1.5 h of sleep), without affecting tympanic temperature. Bright light also increased REM latency, NREM period length, EEG spectral power in low frequency, 0.75-8 Hz and sigma, 12–14 Hz (sleep spindle) bandwidths during the first hour of sleep, and power of all frequency bands (0.5–32 Hz) within the first NREMP. Potentiation of EEG slow wave activity (0.5-4.0 Hz) by bright light persisted through the end of the second NREMP. The enhanced low-frequency power and delayed REM sleep after bright light exposure could represent a circadian phase-shift and/or the effect of an elevated rectal temperature, possibly mediated by the suppression of melatonin. 相似文献
30.
Data are presented on the effects of generalized tonic-clonic seizures on the structure of the one-day sleep-waking cycle
in Krushinskii-Molodkina (KM) rats, which have a genetic predisposition to audiogenic convulsions. Spectral and correlation
analysis of EEG activity in the hippocampus, caudate nucleus, medial central nucleus of the thalamus, and in the somatosensory,
visual, and auditory regions of the cortex of these animals was carried out for time intervals before and after convulsions.
After seizures, rats showed a prolonged (up to 3.5 h) reduction in fast-wave sleep (FWS) with no subsequent compensatory increase
in this shase in the sleep-waking cycle, while a disturbance in slow-wave sleep (SWS) was minor and short-lived (not more
than 2 h). It is suggested that generalized paroxysmal attacks predominantly involve disorganization of the function of the
systems regulating FWS, while the synchronizing mechanisms of the brain, responsible for SWS, are affected to a lesser extent.
Laboratory of the Evolution of Sleep and Waking (Director G. A. Oganesyan), I. M. Sechenov Institute of Evolutionary Physiology
and Biochemistry, Russian Academy of Sciences, St. Petersburg. Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova,
Vol. 81, No. 10, pp. 1–8, October, 1995. 相似文献