Necrotizing soft tissue infection of the upper extremities in patients with diabetes mellitus in a tertiary care center-a retrospective study

BackgroundNecrotizing soft tissue infection (NSTI) of the upper extremities is a rare, but potentially life-threatening infection in patients with type 2 diabetes mellitus (T2DM). We analyzed the clinical characteristics and the outcome of NSTI of upper extremities in these patients.MethodsThis was a retrospective study analyzing the clinical characteristics and the outcomes of 33 T2DM patients with NSTI of upper extremities, who were treated in the department of hand surgery between January 2011 and December 2017.ResultsPredisposing factors for NSTI were recognized in 16 (48.5%) patients. Eleven (33.3)% patients had septic shock while ten (30.3%) had acute renal insufficiency at the time of presentation, of which six required dialysis. The mean glycosylated hemoglobin was 9.6(±2.6)% and the random plasma glucose at admission was 271(±96) mg/dl. Monomicrobial infection was seen in 16(49%) patients and polymicrobial infection in 9(27%) patients. Gram-positive causation was found in 25(66%) patients. Twelve (36.4%) patients required amputation, six (18.2%) of which were major. Death occurred in more than one-fifth (21.2%) of the patients during treatment.ConclusionNecrotizing soft tissue infection of the upper extremities in T2DM is associated with increased risk of severe infection, amputation and mortality.     

血液提取物在前牙软组织美学方面的应用

如何恢复前牙美学区退缩或缺损的软组织,是目前口腔医学的研究热点。血液提取物因制备技术简单、使用安全且含有高浓度生长因子,近年来被广泛应用于软硬组织增量技术。根据制备方法的不同,血液提取物可分为三代：第一代富血小板血浆、第二代富血小板纤维蛋白和第三代改良富血小板纤维蛋白、浓缩生长因子和注射型富血小板纤维蛋白。本文将介绍各种血液提取物的历史和制备方法,并对其在前牙软组织美学方面的研究及应用进展做一综述。     

Gelatamp胶质银明胶海绵在前牙区Ⅱ型种植位点的临床应用研究

目的:观察Gelatamp胶质银明胶海绵在前牙区Ⅱ型种植位点的临床应用效果。方法:选择40例前牙区拔牙拟作Ⅱ型种植的病人,随机分层分为Gelatamp胶质银明胶海绵填塞止血组(试验组)及棉球压迫止血组(对照组)。拔牙后,试验组在牙槽窝置入Gelatamp胶质银明胶海绵,对照组常规紧咬棉球30分钟后取出,观察比较两组的止血效果和4周后行Ⅱ型种植手术前拔牙位点软组织愈合的情况。结果:试验组拔牙创出血很快停止,出血平均时间为0.67分,试验组、对照组止血效果有效率分别为100%,80%,差异有统计学意义(P<0.05)。在4周后Ⅱ型种植手术前试验组、对照组的软组织愈合良好率分别为70%和40%,差异有统计学意义(P<0.05)。结论:Gelatamp胶质银明胶海绵,能显著缩短出血时间,有效增强止血效果,具有止血和持久杀菌的双重效果,有利于形成良好的软组织,有利于早期种植体植入后封闭创面,具有一定的临床应用价值。     

Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma

Background: Hibernoma is a rare benign fat-forming soft tissue tumor that differentiates similar to brown fat, hence an origin from remnants of fetal brown adipose tissue has been proposed. Mainly young adults are affected, usually without significant clinical symptoms. Material and methods: We report on four patients with hibernomas, who were treated at our hospital during the last 10 years. The clinicopathologic and immunohistochemical features are presented and treatment and follow-up data discussed. Results: Patients were 2 women and 2 men aged 21-67 years (mean: 45 yrs) who presented with a slowly growing, painless mass. The anatomic location was the thigh, upper arm, lateral thoracic wall and paravertebral soft tissue. Two of them were diagnosed preoperatively through a percutaneous core needle biopsy and the other two underwent surgery because of high clinical and radiological suspicion of liposarcoma. The tumor’s size ranged from 7 cm to 15.5 cm (mean: 11 cm). All were deep-seated subfascial intramuscular masses. Histologically, all four tumors were of the typical variant. All patients underwent a R0-surgical resection of the tumor and they were recurrence-free at last follow-up (mean: 47 months; range: 25-87). Conclusion: Hibernoma may present as huge deep intramuscular soft tissue mass in adults, closely mimicking well differentiated liposarcoma and should be considered in the differential diagnosis of fatty soft tissue tumors in any location. Surgical excision is the treatment of choice. The tumor has no malignant or recurrence potential.     

Comparative Evaluation of Tensile Bond Strength between Silicon Soft Liners and Processed Denture Base Resin Conditioned by Three Modes of Surface Treatment: An Invitro Study

Soft denture liners act as a cushion for the denture bearing mucosa through even distribution of functional load, avoiding local stress concentrations and improving retention of dentures there by providing comfort to the patient. The objective of the present study was to compare and evaluate the tensile bond strengths of silicone-based soft lining materials (Ufi Gel P and GC Reline soft) with different surface pre treatments of heat cure PMMA denture base acrylic resin. Stainless steel dies measuring 40 mm in length; 10 mm in width and 10 mm in height (40 × 10 × 10) were machined to prepare standardized for the polymethyl methacrylate resin blocks. Stainless steel dies (spacer for resilient liner) measuring 3 mm thick; 10 mm long and 10 mm wide were prepared as spacers to ensure uniformity of the soft liner being tested. Two types of Addition silicone-based soft lining materials (room temperature polymerised soft lining materials (RTPSLM): Ufi Gel P and GC Reline soft) were selected. Ufi Gel P (VOCO, Germany), GC Reline soft (GC America) are resilient, chairside vinyl polysiloxane denture reliners of two different manufacturers. A total of 80 test samples were prepared of which 40 specimens were prepared for Group A (Ufi Gel P) and 40 specimens for Group B (GC Reline soft). In these groups, based on Pre-treatment of acrylic resin specimens each group was subdivided into four sub groups of 10 samples each. Sub-group I—without any surface treatment. Sub-group II—sand blasted Sub-group III—treated with Methyl Methacrylate monomer Sub-group IV-treated with chemical etchant Acetone. The results were statistically analysed by Kruscal Wallis test, Mann–Whitney U test, and Independent t test. The specimens treated with MMA monomer wetting showed superior and significant bond strength than those obtained by other surface treatments. The samples belonging to subgroups of GC Reline soft exhibit superior tensile bond strength than subgroups of Ufi Gel P. The modes of failure of all specimens were mostly adhesive in nature. Surface pre treatments by chemical means improved the bond strength between the silicone liners and denture base.     

大型C臂机实时引导下经超细支气管镜肺大疱减容术有效性及其影响因素的初探

目的 初步探讨大型C臂机实时引导下经超细支气管镜肺大疱减容术的有效性及其影响因素.方法 6例肺大疱患者均在大型C臂机实时引导下经超细支气管镜工作通道先后通过微导管向目标细支气管注入利多卡因、自身血、纤维蛋白原、凝血酶.通过患者客观症状、肺功能FEV1、胸部HRCT、血气分析、6分钟步行距离等指标评价术式的有效性及其影响因素.结果 6例患者中,术后完全有效2例,明显有效1例,基本有效2例,完全无效1例(有效率83.3％).有效性影响因素可能包括肺大疱周围肺组织对所注入的减容药物反应程度、H RCT扫描肺大疱大小时呼吸动度、肺大疱周围组织内源性弹性回缩作用力大小及其各个作用力的方向、患者特异质等.结论 应用大型C臂机实时引导下经超细支气管镜肺大疱减容术,可以避免手术治疗并发症的发生,缩短住院时间,改善肺功能,提高患者生活状态,值得进一步推广.     

皮瓣修复受损手外伤软组织缺损的临床观察

目的：分析皮瓣修复手术应用于受损手外伤软组织缺损的效果。方法：选取我院2011年10月～2012年10月收治的110例手外伤软组织缺损患者,给予皮瓣修复手术,分别给予交臂、鱼际、邻指皮瓣等皮肤缺损修复。结果：经过清创后,53例（47．5％）患者I期皮瓣修复,57例（52．5％）患者II期皮瓣修复,20例（14．8％）患者给予鱼际皮瓣修复,25例（20．4％）患者给予邻指皮瓣修复,50例（40．9％）患者给予髂腹股沟皮瓣修复。本组实验中,共成功修复109例,成功率99．2％。结论：针对手外伤软组织缺损患者,根据缺损状态,给予不同皮瓣修复,可获得良好的治疗效果,有利于手部功能修复。     

Impingement and stability of total hip arthroplasty versus femoral head resurfacing using a cadaveric robotics model

We identified and compared the impingent‐free range of motion (ROM) and subluxation potential for native hip, femoral head resurfacing (FHR), and total hip arthroplasty (THA). These constructs were also compared both with and without soft tissue to elucidate the role of the soft tissue. Five fresh‐frozen bilateral hip specimens were mounted to a six‐degree of freedom robotic manipulator. Under load‐control parameters, in vivo mechanics were recreated to evaluate impingement free ROM, and the subluxation potential in two “at risk” positions for native hip, FHR, and THA. Impingement‐free ROM of the skeletonized THA was greater than FHR for the anterior subluxation position. For skeletonized posterior subluxations, stability for THA and FHR constructs were similar, while a different pattern was observed for specimens with soft tissues intact. FHR constructs were more stable than THA constructs for both anterior and posterior subluxations. When the femoral neck is intact the joint has an earlier impingement profile placing the hip at risk for subluxation. However, FHR design was shown to be more stable than THA only when soft tissues were intact. © 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:1108–1115, 2013