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991.
992.
目的:观察冰蜜生肌膏促进体外培养兔成纤维细胞增殖的影响。方法:采用消化分离法进行兔成纤维细胞的原代培养,通过形态学和免疫组织化学的方法鉴定成纤维细胞。第3代纯化的成纤维细胞分为5组,空白对照组每孔加入等量的PBS,实验组每孔分别加入125、62·5、31·25、15·625mg/ml的冰蜜生肌膏提取液进行培养,培养24、48、72h后分别行MTT法检测每孔的光吸收值(OD值)。结果:冰蜜生肌膏提取液加入到成纤维细胞中培养24、48、72h后,经MTT法检测,不同浓度(浓度分别为125、62·5、31·25、15·625mg/ml)冰蜜生肌膏与对照组OD值比较差异有显著性统计学意义(P<0·05)。结论:15·625mg/ml浓度冰蜜生肌膏对成纤维细胞的生长有明显促进作用(P<0·05),药物浓度在15·625~62·5mg/ml时其作用随药物浓度升高而增加,并在浓度为62·5mg/ml时达到最大效应值(P<0·01),当药物浓度大于62·5mg/ml时则作用趋向于饱和,提示一定浓度范围内的冰蜜生肌膏药液能明显增加成纤维细胞数量,且促进作用和浓度呈显著依赖性。 相似文献
993.
994.
茶叶多糖是一种复合杂多糖,具有许多生物活性。作者系统地介绍了茶叶多糖的提取、分离、纯化、纯度鉴定及相对分子质量测定的方法,以及其含量和组成、理化性质、化学结构及空间构象、生物活性等方面的研究进展,并对上述方法及研究进展进行了分析和评述。 相似文献
995.
Bayesian decision theoretic approaches (BDTAs) have been widely studied in the literature as tools for designing and conducting phase II clinical trials. However, full Bayesian approaches that consider multiple endpoints are lacking. Since the monitoring of toxicity is a major goal of phase II trials, we propose an adaptive group sequential design using a BDTA, which characterizes efficacy and toxicity as correlated bivariate binary endpoints. We allow trade‐off between the two endpoints. Interim evaluations are conducted group sequentially, but the number of interim looks and the size of each group are chosen adaptively based on current observations. We utilize a loss function consisting of two components: the loss associated with accruing, treating, and monitoring patients, and the loss associated with making incorrect decisions. The performance of our Bayesian modeling, and the operating characteristics of decision rules under a wide range of loss function parameters are evaluated using seven scenarios in a simulation study. Our method is illustrated in the context of a single‐arm phase II trial of bevacizumab, gemcitabine, and oxaliplatin in patients with metastatic pancreatic adenocarcinoma. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
996.
目的 探讨亚低温治疗高温高湿环境下重型颅脑损伤的护理方法。方法 高温高湿环境下的重型颅脑损伤患者60例,随机分为亚低温治疗组和对照组。规范护理程序,严密观察病人生命体征变化,采取积极护理措施,减少并发症。结果 亚低温治疗24h后颅内压逐渐下降,脑组织PO2逐渐上升,伤后3个月亚低温治疗组的良好率明显高于对照组(P〈0.05),而死亡率明显低于对照组(P〈0.01)。结论 精心护理有助于改善亚低温治疗的高温高湿环境下重型颅脑损伤病人的预后。 相似文献
997.
p. karling Å. danielsson r. adolfsson † & k.-f. Norrback † 《Neurogastroenterology and motility》2007,19(11):896-904
There is bidirectional comorbidity between anxiety/depression and irritable bowel syndrome (IBS). To investigate the prevalence of IBS symptoms, and factors associated with gastrointestinal symptoms in patients with recurrent depressive disorder. Patients (n = 95) with recurrent type of major depression according to DSM-IV criteria and sex- and age-matched controls (n = 190) were sent questionnaires investigating symptoms of IBS [Gastrointestinal Symptom Rating Scale (GSRS)-IBS] and symptoms of anxiety and depression [Hospital Anxiety and Depression Scale (HADS)]. Medical records were checked over a 10-year period for chronic somatic symptoms or diseases. Seventy-three patients with unipolar disorder (mean age 63.6 years SD 13.8; range 23-86 years) and 156 controls (mean age 59.2 years SD 11.6, range 21-85 years) responded. Patients with recurrent depression had higher GSRS-IBS scores and showed a strong correlation between symptoms of IBS and anxiety-depression (r(s) = 0.54; P < 0.001). IBS symptoms were also associated with multiple pain symptoms, higher health-seeking behaviour and selective-serotonin-reuptake inhibitor intake. However, patients with recurrent depression (n = 46) in remission (HADS-Depression score <8) did not have more symptoms of IBS than controls (GSRS-IBS median score 6.0 vs 6.5; P = 0.46). There is a strong association between symptoms of IBS and symptoms of anxiety and depression, whereas depressive patients in remission do not have more IBS symptoms than controls. 相似文献
998.
目的了解重庆市肺结核可疑症状者就诊延迟程度,探索影响就诊延迟的主要因素,以及流动人口和常住人口间影响因素的差异。方法在重庆市流动人口较多的两个区中,对在随机抽取的20所医疗机构就诊,年龄在15岁以上的肺结核可疑症状者进行问卷调查。结果590份有效问卷中,就诊延迟中位时间为19 d;其中常住人口15 d,流动人口为22.5 d。影响就诊延迟的主要因素有:出现症状后是否愿意就诊、职业、文化程度、结核病史、恩格尔系数、就诊点远近、有无医疗保障、婚姻状况和性别。结论肺结核可疑症状者就诊延迟较为严重;影响其就诊延迟的主要因素有出现症状后是否愿意就诊等。采取综合性干预措施,有助于减少肺结核可疑症状者就诊延迟,提高结核病发现率。 相似文献
999.
Mohammad H. Ebrahimzadeh MD Mohammad T. Rajabi MD 《The Journal of foot and ankle surgery》2007,46(6):429-433
Long-term clinical and functional outcomes for patients undergoing foot and ankle amputations are not well documented. We attempted to document long-term outcomes for patients who required lower extremity amputations as a result of wounds suffered during wartime. For this study, 27 Iranian soldiers who had wounds requiring amputation of the foot and ankle were selected for follow-up. The participants' wartime medical records were reviewed, a clinical examination was performed, and each participant completed a questionnaire. Postamputation follow-up averaged 17.5 years. The most prevalent (66.6%) cause of injury was a land mine. The prevalences of different clinical symptoms reported by the amputees at the time of the last follow-up were as follows: 11 (40.7%) with phantom sensation, 6 (22.2%) with phantom pain, 12 (44.4%) with stump pain, 12 (44.4%) with back pain, 9 (33.3%) with contralateral knee pain, and 4 (14.8%) with ipsilateral knee pain; 20 (74%) reported treatment for psychological conditions. In regard to social conditions, 13 (48.1) were currently employed, or had been employed, for a number of years after the amputation; 26 (96%) had children, and all of the patients were married. The results of this observational study indicate that individuals have significant long-term pain and discomfort after war-related lower extremity amputation. Although all 27 (100%) of the amputees were able to maintain satisfactory family functioning, only 13 (48.1%) of the study participants were able to remain productively employed after undergoing amputation, and 20 (74%) reported long-term psychological problems in addition to their physical pain. 相似文献
1000.
目的探讨大学生的自我和谐与交往焦虑的特点和关系。方法采用自我和谐量表和交往焦虑量表对310名大学生进行调查。结果男生在自我灵活性和自我和谐上得分低于女生(P〈0.01),研究生在自我灵活性上得分低于本科生(P〈0.01),理科生在社交焦虑上得分低于文科生(P〈0.05);高自我和谐组在社交焦虑上得分低于低自我和谐组(P〈0.05);从总体上看,社交焦虑与自我与经验的不和谐、自我刻板性、总体的自我和谐均呈正相关(P〈0.01)。结论大学生的自我和谐和社交焦虑之间均存在相关,自我和谐对社交焦虑具有良好的预测作用。 相似文献