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91.
目的 分析重型危重型新型冠状病毒肺炎(简称新冠肺炎)发生的危险因素,为早期预测新冠肺炎轻型普通型进展为重型危重型提供依据。 方法 收集2020年1月17日—3月14日在长沙市第一医院收治的新冠肺炎确诊患者的基本情况、流行病学、临床和实验室资料。采用回顾性队列分析研究重型危重型新冠肺炎发生的危险因素,单因素χ2检验和多因素logistic回归分析相关指标。 结果 169例患者纳入研究,其中136例为轻型普通型,33例为重型危重型。单因素分析显示,重型危重型和轻型普通型在年龄、饮酒史、感染地为湖北、有明确接触史、合并慢性心脏病、高血压、总蛋白、白蛋白、淋巴细胞、血糖、乳酸脱氢酶、降钙素原、C反应蛋白差异有统计学意义(P<0.05);多因素logistic分析显示,有饮酒史(OR=3.06)、有慢性心脏疾病(OR=15.26)、总蛋白偏低(OR=2.13)、入院时血糖升高(OR=4.91)、C反应蛋白升高(OR=12.34)为重型危重型新冠肺炎的独立危险因素(P<0.05)。 结论 有饮酒史、有慢性心脏疾病、入院时总蛋白偏低、血糖升高、C反应蛋白升高为重型危重型新冠肺炎的危险因素。提示医师在诊疗过程中应重点关注有以上因素的轻型普通型新冠肺炎患者。 相似文献
92.
Sina Schwarzkopf Adalbert Krawczyk Dietmar Knop Hannes Klump Andreas Heinold Falko M. Heinemann Laura Thümmler Christian Temme Marianne Breyer Oliver Witzke Ulf Dittmer Veronika Lenz Peter A. Horn Monika Lindemann 《Emerging infectious diseases》2021,27(1):122
We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 (17%) study participants had borderline or negative results to an ELISA detecting IgG against the S1 protein of SARS-CoV-2. We analyzed participants with PCR-confirmed infection who had strong antibody responses (ratio >3) as positive controls and participants without symptoms of SARS-CoV-2 infection and without household contact with infected patients as negative controls. Using interferon-γ ELISpot, we observed that 78% of PCR-positive volunteers with undetectable antibodies showed T cell immunity against SARS-CoV-2. We observed a similar frequency (80%) of T-cell immunity in convalescent donors with strong antibody responses but did not detect immunity in negative controls. We concluded that, in convalescent patients with undetectable SARS-CoV-2 IgG, immunity may be mediated through T cells. 相似文献
93.
Md R. Rahaman Karen A. Alroy Chris A. Van Beneden Michael S. Friedman Erin D. Kennedy Mahmudur Rahman Arunmozhi Balajee A.K.M. Muraduzzaman Tahmina Shirin Meerjady S. Flora Eduardo Azziz-Baumgartner 《Emerging infectious diseases》2021,27(1):324
In April 2017, surveillance detected a surge in severe acute respiratory infections (SARI) in Bangladesh. We collected specimens from SARI patients and asymptomatic controls for analysis with multipathogen diagnostic tests. Influenza A(H1N1)pdm09 was associated with the SARI epidemic, suggesting that introducing vaccines and empiric antiviral drugs could be beneficial. 相似文献
94.
Kenneth Siu-Sing Leung Timothy Ting-Leung Ng Alan Ka-Lun Wu Miranda Chong-Yee Yau Hiu-Yin Lao Ming-Pan Choi Kingsley King-Gee Tam Lam-Kwong Lee Barry Kin-Chung Wong Alex Yat Man Ho Kam-Tong Yip Kwok-Cheung Lung Raymond Wai-To Liu Eugene Yuk-Keung Tso Wai-Shing Leung Man-Chun Chan Yuk-Yung Ng Kit-Man Sin Kitty Sau-Chun Fung Sandy Ka-Yee Chau Wing-Kin To Tak-Lun Que David Ho-Keung Shum Shea Ping Yip Wing Cheong Yam Gilman Kit-Hang Siu 《Emerging infectious diseases》2021,27(1):196
Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10−3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread. 相似文献
95.
Pyoeng Gyun Choe Chang Kyung Kang Hyeon Jeong Suh Jongtak Jung Kyoung-Ho Song Ji Hwan Bang Eu Suk Kim Hong Bin Kim Sang Won Park Nam Joong Kim Wan Beom Park Myoung-don Oh 《Emerging infectious diseases》2021,27(1):327
We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic persons and 11 patients with pneumonia. The geometric mean titer of neutralizing antibodies declined from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response. 相似文献
96.
Andrea Calcagno Valeria Ghisetti Teresa Emanuele Mattia Trunfio Silvia Faraoni Lucio Boglione Elisa Burdino Sabrina Audagnotto Filippo Lipani Marco Nigra Antonio DAvolio Stefano Bonora Giovanni Di Perri 《Emerging infectious diseases》2021,27(1):303
We measured severe acute respiratory syndrome coronavirus 2 spike protein subunits S1/S2 antibodies by using capillary electrophoresis and a chemiluminescence immunoassay for 5,444 active healthcare workers in Italy. Seroprevalence was 6.9% and higher among participants having contact with patients. Seroconversion was not observed in 37/213 previously infected participants. 相似文献
97.
Fabian Heinrich Kira Meißner Felicia Langenwalder Klaus Püschel Dominik Nrz Armin Hoffmann Marc Lütgehetmann Martin Aepfelbacher Eric Bibiza-Freiwald Susanne Pfefferle Axel Heinemann 《Emerging infectious diseases》2021,27(1):329
Analyses of infection chains have demonstrated that severe acute respiratory syndrome coronavirus 2 is highly transmissive. However, data on postmortem stability and infectivity are lacking. Our finding of nasopharyngeal viral RNA stability in 79 corpses showed no time-dependent decrease. Maintained infectivity is supported by virus isolation up to 35 hours postmortem. 相似文献
98.
Catherine A. Hogan ChunHong Huang Malaya K. Sahoo Hannah Wang Becky Jiang Mamdouh Sibai Marisa Holubar Roshni Mathew James Zehnder Benjamin A. Pinsky 《Emerging infectious diseases》2021,27(2):632
We developed an assay that detects minus-strand RNA as a surrogate for actively replicating severe acute respiratory syndrome coronavirus 2. We detected minus-strand RNA in 41 persons with coronavirus disease up to 30 days after symptom onset. This assay might inform clinical decision-making about patient infectiousness. 相似文献
99.
Lorenz Ulrich Anna Michelitsch Nico Halwe Kerstin Wernike Donata Hoffmann Martin Beer 《Emerging infectious diseases》2021,27(4):1193
After experimental inoculation, severe acute respiratory syndrome coronavirus 2 infection was confirmed in bank voles by seroconversion within 8 days and detection of viral RNA in nasal tissue for up to 21 days. However, transmission to contact animals was not detected. Thus, bank voles are unlikely to establish effective transmission cycles in nature. 相似文献
100.
Adrian Trenholme Rachel Webb Shirley Lawrence Sharon Arrol Susan Taylor Shanthi Ameratunga Catherine A. Byrnes 《Emerging infectious diseases》2021,27(2):641
In March 2020, a national elimination strategy for coronavirus disease was introduced in New Zealand. Since then, hospitalizations for lower respiratory tract infection among infants <2 years of age and cases of respiratory syncytial or influenza virus infection have dramatically decreased. These findings indicate additional benefits of coronavirus disease control strategies. 相似文献