Predictive factors analysis of cesarean scar pregnancy treated by local injection of Lauromacrogol combined with curettage

To explore factors related to local injection of Lauromacrogol combined with curettage in the treatment of cesarean scar pregnancy. A total of 24 successful and 8 unsuccessful cases were included. The age, gravidity, parity, times of cesarean section, interval from the last cesarean section, preoperative human chorionic gonadotropin (HCG), HCG on the first day after operation, decreasing rate of HCG on the first day after operation, average diameter of gestational sac, and preoperative vaginal bleeding days were analyzed. There were no significant differences of age, gravidity, parity, previous cesarean section times between groups. The differences of preoperative HCG, HCG on the first day after operation, the decreasing rate of HCG, gestational sac diameter, preoperative vaginal bleeding days were statistically significant between groups. The interval from the last cesarean section and the decreasing rate of HCG were protective factors, while the mean diameter of gestational sac and period of vaginal bleeding before operation were risk factors for the success of the treatment. The mean diameter of gestational sac owned the best predictive value.     

Effects of mechanical forces on the formation of cutaneous wounds during skin expansion and emerging therapies for wound healing and scar prevention

Objectives:To update a possible role of cosmeceutical topic treatment to obtain a better scar.Methods:This is a preliminary supportive study. A total of 14 patients who went to the General Hospital of Mexico City, Mexico, between May and December 2020, for breast reconstruction were included in the current study. The biopsies were carried out to the scar area of the previous I° and II° surgery. The patients were thus divided into 2 groups: those who used Cicolea cream® as a treatment supplement and those who used only petrolatum.Results:Collagen fibers arranged in a regular pattern in the group treated with Cicolea compared to dispersed collagen fibers in the group treated with pure petrolatum. Furthermore, the patients who presented hypertrophic or keloid scars secondary to mastectomy, developed after insertion of breast expanders an organized scarring process, with improvement of scar if treated with Cicolea.Conclusion:Based on our observations, it is possible to propose that the action of the polyphenols present in the different components of Cicolea® cream leads to a better evolution of the wound healing compared to the action of petrolatum composition.     

阴式子宫瘢痕妊娠病灶清除术的临床疗效评价

目的 观察阴式子宫瘢痕妊娠病灶清除术治疗剖宫产术后瘢痕妊娠的意义.方法 选取我院2018年10月—2019年10月收治的64例剖宫产术后瘢痕妊娠患者的临床资料,根据手术方案的不同,将实施阴式子宫瘢痕妊娠病灶清除术的病例作为观察组(n=33),将选择腹腔镜子宫瘢痕妊娠病灶消除术的病例作为对照组(n=31).比较两组手术疗...     

原发性骨膜增生厚皮症伴重度贫血1例

患者男,39岁,面部皮肤肥厚、四肢肢端肥大20年,间断头晕乏力1年.查体:重度贫血貌,睑结膜、口唇及甲床苍白;头面部皮肤肥厚、皱褶、呈回状颅皮;双下肢皮肤肥厚,手指及足趾呈杵状;皮损颜色正常,触之略韧;踝关节肿胀无压痛、活动自如.X线检查提示右腓骨中段髓腔密度增多,腓骨中段及胫骨下段后缘骨皮质增厚.血常规重度正常细胞低...     

Silencing of Nesprin‐2 inhibits the differentiation of myofibroblasts from fibroblasts induced by mechanical stretch

Mechanical force plays a pivotal role in the pathogenesis of hypertrophic scar (HTS). Dermal fibroblasts and myofibroblasts are the key cells involved in HTS. Myofibroblasts in HTS possess different biochemical and biophysical characteristics by which myofibroblasts are often distinguished from fibroblasts. The role of mechanotransducers outside the nucleus in the pathogenesis of HTS has been reported in many studies. However, the role of Nesprin‐2 in HTS is not clear. Hence, we aim to construct a cell model of HTS and explore the role of Nesprin‐2 in this process. Myofibroblasts and fibroblasts were isolated from HTS and healthy skin tissues of the same patient. Fibroblasts were exposed to cyclic stretch with 10% magnitude and a frequency of 0.1 Hz for 3 days, 5 days, and 7 days, respectively. After the cell model was confirmed, fibroblasts transfected with siRNA targeting human Nesprin‐2 were exposed to cyclic stretch. The mechanical behaviour and biochemical reaction of the dermal fibroblasts were analysed. The stretched fibroblasts at day 5 showed the same mechanotransductive and biochemical features as unstretched myofibroblasts. Mechanical strain could induce the myofibroblasts differentiation and a cell model of HTS was established successfully at day 5. The expressions of lamin A/C, alpha‐smooth muscle actin, transforming growth factor beta 1, and collagen type I in fibroblasts were reduced by the silencing of Nesprin‐2. Mechanical strain could induce the myofibroblasts differentiation and silencing of Nesprin‐2 could block the mechanical stimulation of terminal myofibroblasts differentiation. Nesprin‐2 might be a potential target to treat the HTS.     

促肝细胞生长素联合复方丹参注射液治疗慢性重型肝炎临床疗效观察

目的：探讨慢性重型肝炎的治疗方法,降低其病死率。方法：在综合治疗的基础上,采用促肝细胞生长素（HGF）联合复方丹参注射液治疗慢性重型肝炎。结果：HGF与丹参合用,能降低血清胆红素（SB）,缩短凝血酶原时间（PT）复常时间,降低病死率,与对照组相比有显著性差异（P＜0.01）。结论：慢性重型肝炎治疗的疗程较长,二者联合使用能有效缩短疗程,且二者的使用环节不同,可能有协同或相加作用。     

深度手烧伤的治疗及功能康复

目的 :探讨深度手烧伤早期创面修复及功能康复最好的治疗方法。方法 :应用中厚皮、异体去细胞真皮基质作支架加自体刃厚皮片移植 ,腹部真皮血管网皮片及超薄皮瓣移植等手术方式 ,进行深度手烧伤早期切削痂。结果 :2 94例 4 6 2只手功能良好者 138例 2 32只手 (5 0 % ) ,功能较好者 79例 134只手 (2 9% ) ,功能障碍者 77例 96只手 (2 1% )。结论 :应用早期切削痂植皮的方法可减少瘢痕增生和畸形 ,使深度手烧伤后获得满意的外形和功能     

傣药咪多领(云南琵琶甲)对增生性瘢痕中表皮干细胞干性及Hedgehog信号通路的影响

目的 探讨傣药咪多领(云南琵琶甲)对增生性瘢痕中表皮干细胞干性及Hedge-hog信号通路的影响.方法 构建新西兰大耳兔增生性瘢痕模型,并分离增生性瘢痕组织中表皮干细胞.将动物随机分为对照组、模型组、阳性对照组(PC组,用复方肝素钠尿囊素凝胶干预)及傣药咪多领0.667、1.334、2.668 g/kg组;表皮干细胞分...     

121例颈部瘢痕挛缩治疗分析

目的探讨颈部烧伤瘢痕挛缩的手术治疗方法及效果。方法本组121例烧伤后颈部瘢痕挛缩患者(无1例为新鲜烧伤),根据病情程度分别采用"Z"成形术、厚皮片移植术、"Z"成形加厚皮片移植术、邻位皮瓣移植术和邻位皮瓣加皮片移植术进行手术整复。对于烧伤后颌颈瘢痕严重挛缩的患者,采用仅对挛缩瘢痕切开松解而不切除的手术方法,灵活设计切口,利用挛缩部位已成熟的瘢痕形成较大面积三角形瘢痕瓣来修复创面;切口解剖深度直达舌骨甲状软骨沟平面并彻底松解挛缩组织,以塑造明显的颌颈角。结果本组121例患者的瘢痕挛缩得到最大程度的松解,均获得满意或较为满意的近期疗效。患者颈部活动自如,外观改善显著,颌颈角明显。结论对于供皮区缺乏的严重颈部瘢痕挛缩的患者,利用特殊切口及设计面积较大的瘢痕瓣修复部分创面,同样可获得满意疗效;切口解剖至舌骨甲状软骨沟深度,并彻底松解所有挛缩的软组织,可显现较为美观的颌颈角。