多通道光纤化学传感器连续在位监测固体制剂的体外溶出度多通道光纤化学传感器连续在位监测固体制剂的体外溶出度

目的 为连续在位监测固体制剂的体外溶出度,自制多通道光纤化学传感溶出仪。方法 用自制光纤荧光溶出度监测仪与ZRS-4型智能溶出仪联用,连续在位监测氧氟沙星片、甲硝唑片、呋喃妥因肠溶片的体外溶出度,溶出曲线经微机从5种常用数学模型中根据相关系数R值,优选最佳模型进行拟合。结果 方法的回收率分别为97.4%～104.4%, 97.4%～103.8%, 96.6%～102.1%,日内、日间的RSD均小于5%。经与中国药典2000版方法及美国药典23版方法对照,各时间点药物累积溶出量和拟合后提取的参数均无显著性差异(P>0.05)。结论 本法简便、快速,结果准确、可靠,重现性好。     

Use of tactile stiffness to detect fatigue in the latissimus dorsi muscle

In clinical settings, no method has been established to examine the fatigue of a latissimus dorsi muscle (LDM) preconditioned for cardiomyoplasty. We examined the feasibility of measuring muscle stiffness (tactile stiffness) to evaluate muscle fatigue in situ using our tactile sensor. We stimulated canine LDM with burst pacing and monitored both stiffness and tension to determine their relationship. In both dissected LDM and LDM in situ, the decrements of these parameters during burst pacing were compared between preconditioned and unconditioned LDM. In measurement in situ, the sensor probe was placed on the LDM through a small incision. Strong statistical correlation was shown between stiffness and tension (r = 0.935). In decrements of stiffness in situ, there were statistically significant differences between preconditioned and unconditioned LDM. Our tactile sensor system can provide an efficient method for evaluating fatigue of muscles in situ without measuring muscle tension.     

Incidence of Chromosomal Abnormalities from a Morphologically Normal Cohort of Embryos in Poor-Prognosis Patients

Purpose: Preimplantation genetic diagnosis of aneuploidy was performed on the embryos yielded by 70 poor-prognosis patients, with the aim of transferring those with a normal chromosomal complement, thus possibly increasing the chances of pregnancy. Methods: Multicolor fluorescence in situ hybridization (FISH) was applied for the simultaneous detection of chromosomes X, Y, 13, 16, 18, and 21. Inclusion criteria were (1) a maternal age of 36 years or older (n = 33), (2) three or more previous in vitro fertilization cycles (n = 20), and (3) an altered karyotype (n = 17). Results: A total of 412 embryos underwent FISH, resulting in 234 (57%) that were chromosomally abnormal. Euploid embryos were available for transfer in 59 patients, generating 19 pregnancies (32%), with an implantation rate of 19.9%. Conclusions: High rates of chromosomally abnormal embryos in poor-prognosis patients can determine repeated in vitro fertilization failures when embryo selection is performed on the basis of morphological criteria alone. Hence, the FISH analysis could represent the prevailing approach for the identification of embryos possessing full potential for developing to term.     

全自动血压计智能校准仪的研发

为了提高血压计校准的速度和准确性,本产品运用新型压力传感器,特殊的8955单片机调压控制程序,很好的解决了血压计(表)的校准问题.     

气管导管位置检测仪的研制

利用Hall传感器设计了一个气管导管位置检测仪来快速检测气管导管的位置.气管插管时,Hall传感器探头固定在病人颈部皮肤上,顶端带有小磁铁的管芯随气管导管一起进入气管中,根据检测到的磁场强度的大小,测量出探头与磁铁间的距离,从而判断出气管导管的位置.经临床测试,该检测仪性能可靠,测量准确,可以用于教学及临床气管插管时气管导管的定位.     

RecA蛋白-互补单链DNA探针提高压电基因传感器灵敏度的实验研究

目的研究利用RecA蛋白-互补单链DNA探针与固定的肽核酸(bis-PNA)探针相结合提高压电基因传感器的灵敏度的可行性。方法基因传感器阵列固定上针对乙肝病毒的bis-PNA探针,加入靶DNA与之反应,然后加入预先处理过的的RecA蛋白-互补单链DNA探针。结果直接加入靶DNA所引起的频率改变为15.83±7.31Hz,反应时间为45.16±12.87min,加入RecA蛋白-互补单链DNA探针(浓度为3.0mg/ml),所引起的频率改变最为明显,为112.16±12.7Hz。结论在反应体系中加入RecA蛋白-互补单链DNA探针,能有效地提高压电基因传感器的灵敏度,明显缩短反应体系时间。     

利用Alopex改进的粒子群优化算法及其在软测量建模中的应用

提出了一种利用A lopex算法改进的粒子群优化算法,并将其应用于神经网络的建模中。改进的粒子群优化算法改善了粒子群优化算法摆脱局部极小点的能力,对典型函数的测试和基于神经网络的软测量建模表明:改进算法的全局搜索能力有了显著提高,特别是对多峰函数能够有效地避免早熟收敛问题。     

用计算机对子宫收缩传感器性能指标测量的研究

研究怎样用计算机自动测量子宫收缩传感器的性能指标。由信号放大器、数字电压表、数据采集器、计算机等组成测量系统。计算机对传感器数据进行自动处理后,给出了相应的性能指标、数据曲线和拟合曲线。     

可穿戴式心电、呼吸传感器与检测系统的研制

叙述了一种可用于移动条件下对重要生命信号（心电、呼吸等）无损检测的可穿戴式传感器及其测量和传输系统的研制。导电纺织面料缝合在普通背心内侧特定位置上作为检测电极，通过缝在背心上的导电纺织线将电极上的信号引出到背心边缘，再连接到信号测量和传输系统，由其中的单片机和激励、放大和处理电路测量心电、心率、呼吸数据，通过RS232串口、蓝牙等通讯方式传送到PC机上，用Visual Basic编写的程序接收并显示图形和数据。     

穴位和非穴位氧分压和钙离子浓度在体实时监测比较

目的:比较穴位与非穴位中氧分压和钙离子浓度的差异。方法:利用自制的传感针,在体监测8只山羊的大肠俞、肝俞和关元俞及其对应的非穴位点的钙离子浓度;并监测肝俞和后三里及其对应非穴位点的氧分压。用方差分析方法对穴位和非穴位钙离子浓度和氧分压的差异和变化趋势进行统计分析。结果:穴位的钙离子浓度和氧分压在整个监测过程中都高于非穴位,差异均有显著性意义。结论:传统的针灸穴位具有高氧分压和高钙离子浓度特性。