Navigation-guided core needle biopsy for skull base and parapharyngeal lesions: a five-year experience

The aim of this study was to evaluate the diagnostic accuracy of navigation-guided core needle biopsy for skull base and parapharyngeal lesions. Twenty patients with skull base and parapharyngeal lesions were included in this study. The preoperative design and intraoperative real-time image guiding was done using an optical navigation system. A spring-loaded semi-automatic biopsy gun and biopsy needle were used for specimen harvesting. Accuracy was established on the basis of the postoperative pathology. All patients underwent needle biopsy successfully without any immediate or delayed complications. The subzygomatic approach was adopted in all cases. The number of passes ranged from three to five. The diagnostic accuracy was 90% (18/20). Navigation-guided core needle biopsy offers an easy approach for the diagnosis of skull base and parapharyngeal lesions, with a high yield of specimens and good patient tolerance.     

Eficacia y seguridad de fosfomicina-trometamol en la profilaxis de la biopsia transrectal de la próstata: estudio prospectivo aleatorizado comparativo con ciprofloxacino

Objectiveprostate biopsy is the standardized diagnostic method for prostate cancer. However, although there is not a standardized protocol, there are recommendations in order to reduce the incidence of complications. The objective of the present work is to assess the efficacy and safety of antibiotic prophylaxis in the prostate biopsy by comparing two antibiotic regimes: two doses of fosfomycin-trometamol 3 g (FMT) every 48 hours with 10 doses of oral ciprofloxacin 500 mg every 12 hours during 5 days.Material and methodsrandomized prospective study was performed with 671 patients who had undergone to walking transrectal ultrasound guided prostate biopsy. Patients of group A (n = 312) were treated with ciprofloxacin, and patients of group B (n = 359) with FMT. Efficacy and tolerability of two prophylactic regimes were compared. Urine culture was carried out at 2 weeks after biopsy. Initially, patients with asymptomatic bacteriuria were not treated with antibiotics; urine culture was repeated after 1 month, persistent bacteriuria was treated according to antibiogram.Resultsno differences between groups were found in age (P = .78), cancer presence (P = .9) or number of biopsy cylinders (P = .93). The mean number of cores obtained was 11.3 ± 3.25 (range 6-20). Digestive intolerance was observed for 9 patients (2.9%) of group A and 10 patients (2.8%) in group B. One patient (.3%) of group A showed severe allergic reaction. In total, 167 patients (24.6%) had complications: 16 (2.4%) fever, 47 (6.9%) hemospermia, 81 (11.9%) hematuria, 7 (1%) rectal bleeding and 16 (2.4%) urinary retention. No statistically differences between groups were observed (27.6% vs. 22.6%; P = .17). However, hemospermia was more frequent in group A (9.9% vs. 4.5%; P = .006). Bacteriuria after biopsy was detected in 44 patients (6.6%), being more frequent in group B patients (4.2% vs. 8.6%; P = .02) although a higher number of second treatment cycles were not needed (53.9% vs. 29%; P = .17). The likelihood of resistance to ciprofloxacin in patients with bacteriuria in A was greater than that of FMT in B (69.2% vs. 41.9%; P = .0004).Conclusionsantibiotic prophylaxis with FMT (2 doses of 3 g) in prostate biopsy is an alternative as effective and safe as ciprofloxacin (10 doses of 500 mg), which carries lower rate of resistance. According to our experience, this drug is a safe, well-tolerated, and easily manageable prophylactic option, facilitating patient compliance. More prospective multicenter studies are necessary to confirm these findings.     

Therapeutic attitude towards internal mammary chain drainage in patients with breast cancer

Internal mammary chain (IMC) is one of the main local lymph drainages in breast cancer. However, internal mammary chain sentinel lymph node biopsy (IMC-SLNB) is not always performed.The purpose of this research is to evaluate the outcomes of IMC-SLNB in our institution from 2008 to 2014. We analyzed 1346 women with breast cancer. Six-hundred twenty-two sentinel node biopsies were carried out, one out of ten in IMC territory. Adjuvant radiotherapy in this area was added when positive.IMC-SLNB is feasible, it may change tumour stage, modify adjuvant therapy and change prognosis in selected patients.     

经皮肾穿刺微造瘘碎石取石术治疗复杂肾结石的临床应用

目的 通过观察经皮肾穿刺微造瘘碎石取石术(MPCNL)治疗复杂肾结石的临床疗效,总结其临床价值.方法 回顾性分析2010~2011年期间收治的复杂性肾结石患者200例,其中100例患者采用经皮肾穿刺微造瘘碎石术治疗,另外100例患者进行常规的体外碎石术(ESWL).观察两组的治疗效果,主要是对住院时间、并发症,碎石率、复发率进行比较.结果观察组中住院时间、并发症发生率、碎石率、复发率等均与对照组有明显差异具有统计学意义 (P<0.05).经皮肾穿刺微造瘘碎石取石术治疗复杂肾结石的临床疗效有着姣好的临床评价.结论 采用经皮肾穿刺微造瘘碎石取石术(MPCNL)治疗复杂肾结石的效果比常规治疗的效果好,碎石率高,复发率小.对肾结石的治疗效果明显,值得临床推广使用.