全文获取类型
收费全文 | 12918篇 |
免费 | 1479篇 |
国内免费 | 258篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 233篇 |
妇产科学 | 212篇 |
基础医学 | 2145篇 |
口腔科学 | 212篇 |
临床医学 | 1320篇 |
内科学 | 2040篇 |
皮肤病学 | 223篇 |
神经病学 | 380篇 |
特种医学 | 128篇 |
外国民族医学 | 1篇 |
外科学 | 866篇 |
综合类 | 916篇 |
现状与发展 | 2篇 |
一般理论 | 10篇 |
预防医学 | 3791篇 |
眼科学 | 97篇 |
药学 | 1323篇 |
2篇 | |
中国医学 | 200篇 |
肿瘤学 | 520篇 |
出版年
2024年 | 40篇 |
2023年 | 364篇 |
2022年 | 439篇 |
2021年 | 793篇 |
2020年 | 694篇 |
2019年 | 765篇 |
2018年 | 706篇 |
2017年 | 645篇 |
2016年 | 618篇 |
2015年 | 647篇 |
2014年 | 910篇 |
2013年 | 1249篇 |
2012年 | 781篇 |
2011年 | 920篇 |
2010年 | 711篇 |
2009年 | 683篇 |
2008年 | 676篇 |
2007年 | 584篇 |
2006年 | 471篇 |
2005年 | 303篇 |
2004年 | 282篇 |
2003年 | 234篇 |
2002年 | 192篇 |
2001年 | 144篇 |
2000年 | 137篇 |
1999年 | 103篇 |
1998年 | 87篇 |
1997年 | 94篇 |
1996年 | 51篇 |
1995年 | 43篇 |
1994年 | 51篇 |
1993年 | 32篇 |
1992年 | 32篇 |
1991年 | 33篇 |
1990年 | 31篇 |
1989年 | 20篇 |
1988年 | 17篇 |
1987年 | 8篇 |
1986年 | 11篇 |
1985年 | 14篇 |
1984年 | 6篇 |
1983年 | 10篇 |
1982年 | 7篇 |
1981年 | 7篇 |
1980年 | 2篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
41.
42.
Objective To evaluate the association of 2616c/T polymorphism in iron regulatory protein 2(IRP2)gene with Alzheimer disease(AD)and Vascular dementia(VD).Methods In this study,281 patients with AD,60 with VD,and 285 normal aged were recruited.The 2616C/T polymorphism in IRP2 gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism.And the cognitive function was assessed with the Mini-Mental State Examination(MMSE).Results (1)No significant difieFences were demonstrated in IRP2 genotype or allele frequencies between AD patients and controls(χ2=2.46,P=0.292;χ2=2.17,P=0.141 respectively).However,when AD patients were stratified by disease severity.the frequency of T allele carriers in the moderate to severe AD patients was 78.0%,significantly higher than that in controls(69.8%;χ2=4.106,P<0.05).Logistic regression analysis demonstrated that the age-,sex-and ApoE-adiusted OR of modcrate to severe AD patient with T allele was 1.62(95% CI=1.03-2.54).The frequency of T allele carriers or T allele in VD patients was higher than that of controls,but the difference was not statistically significant(P>0.05).(2)The frequency of tit genotype or T allele in the moderate to severe AD patients was significantly higher than that in mild AD patients(25.8%vs.12.5%,χ2=5.477,P<0.05;51.9%vs.40.3%,χ2=5.803,P<0.05 respectively).(3)MMSE scores of the AD patients with TT genotype was significantly lower than ones with CC or CT genotype(P=0.028;P=0.014 respectively).Conclusion The 2616C/T polymorphism in the IRP2 gene is possibly associated with moderate to severe AD.but not associated with VD.And the TT genotype may be a risk factor for cognitive impairment of patients with AD in Chinese Han. 相似文献
43.
Alfred Sommer 《International ophthalmology》1994,18(5):287-292
Adapted from Keynote Addresses to the 5th General Assembly of the International Agency for the Prevention of Blindness, Berlin, Germany, May 9, 1994, and to the International Congress of Ophthalmology, Toronto, Canada, June 29, 1994. 相似文献
44.
n. holmén † s. isaksson † m. simrén h. sjövall & l. öhman † 《Neurogastroenterology and motility》2007,19(2):119-125
45.
46.
47.
48.
49.
W. Feleszko J. Jaworska R-D. Rha S. Steinhausen A. Avagyan A. Jaudszus B. Ahrens D. A. Groneberg U. Wahn E. Hamelmann 《Clinical and experimental allergy》2007,37(4):498-505
BACKGROUND: Microbial intestinal colonization in early in life is regarded to play a major role for the maturation of the immune system. Application of non-pathogenic probiotic bacteria during early infancy might protect from allergic disorders but underlying mechanisms have not been analysed so far. OBJECTIVE: The aim of the current study was to investigate the immune effects of oral application of probiotic bacteria on allergen-induced sensitization and development of airway inflammation and airway hyper-reactivity, cardinal features of bronchial asthma. METHODS: Newborn Balb/c mice received orally 10(9) CFU every second day either Lactobacillus rhamnosus GG or Bifidobacterium lactis (Bb-12) starting from birth for consecutive 8 weeks, during systemic sensitization (six intraperitoneal injections, days 29-40) and airway challenge (days 54-56) with ovalbumin. RESULTS: The administration of either Bb-12 or LGG suppressed all aspects of the asthmatic phenotype: airway reactivity, antigen-specific immunoglobulin E production and pulmonary eosinophilia (mean: 137 vs. 17 and 13 cellsx10(3)/mL, respectively). Antigen-specific recall proliferation by spleen cells and T-helper type 2 cytokine production (IL-4, IL-5 and IL-10) by mesenteric lymph node cells also showed significant reduction, while TGF production remained unchanged. Oral LGG administration particularly suppressed allergen-induced proliferative responses and was associated with an increase in numbers of TGF-beta-secreting CD4+/CD3+ T cells in mesenteric lymph nodes (6.5, 16.7%) as well as nearly 2-fold up-regulation of Foxp3-expressing cells in peribronchial lymph nodes. CONCLUSIONS: Neonatal application of probiotic bacteria inhibits subsequent allergic sensitization and airway disease in a murine model of asthma by induction of T regulatory cells associated with increased TGF-beta production. 相似文献
50.
Almost every national and supranational health policy document accords high importance to the need to listen to and ‘empower’
patients. The relationship between pharmaceutical policy and the lay public is not direct but mediated by several actors,
including health care workers, patient organisations, industry and, most recently, the media. Although the overall aim of
health and pharmaceutical policy is to address the needs of all citizens, there are only a few, well organised groups who
are actually consulted and involved in the policymaking process, often with the support of the industry. The reasons for this
lack of citizen involvement in health and pharmaceutical policymaking are many, for example: there is no consensus about what
public involvement means; there is a predominance of special interest groups with narrow, specific agendas; not all decision
makers welcome lay participation; patients and professionals have different rationalities with regard to their views on medicine.
Because the lay public and medicine users are not one entity, one of the many challenges facing policy makers today is to
identify, incorporate and prioritise the many diverse needs. The authors recommend research which includes studies that look
at: lay attitudes towards pharmaceutical policy; lay experiences of drug therapy and how it affects their daily lives; the
problem of identifying lay representatives; the relationship between industry and the consumers; the effect of the media on
medicine users and on pharmaceutical policy itself. The authors acknowledge that although lay involvement in policy is still
in its infancy, some patient organisations have been successful and there are developments towards increased lay involvement
in pharmaceutical policymaking.
This article is the fourth in a series of articles on this topic that will appear in Pharmacy World & Science during 2005. 相似文献