全文获取类型
收费全文 | 11114篇 |
免费 | 987篇 |
国内免费 | 354篇 |
专业分类
耳鼻咽喉 | 72篇 |
儿科学 | 101篇 |
妇产科学 | 388篇 |
基础医学 | 1151篇 |
口腔科学 | 508篇 |
临床医学 | 3726篇 |
内科学 | 1141篇 |
皮肤病学 | 127篇 |
神经病学 | 530篇 |
特种医学 | 560篇 |
外国民族医学 | 17篇 |
外科学 | 808篇 |
综合类 | 1556篇 |
现状与发展 | 2篇 |
预防医学 | 482篇 |
眼科学 | 91篇 |
药学 | 410篇 |
12篇 | |
中国医学 | 143篇 |
肿瘤学 | 630篇 |
出版年
2024年 | 25篇 |
2023年 | 126篇 |
2022年 | 282篇 |
2021年 | 406篇 |
2020年 | 483篇 |
2019年 | 325篇 |
2018年 | 333篇 |
2017年 | 368篇 |
2016年 | 475篇 |
2015年 | 466篇 |
2014年 | 791篇 |
2013年 | 914篇 |
2012年 | 758篇 |
2011年 | 853篇 |
2010年 | 697篇 |
2009年 | 674篇 |
2008年 | 603篇 |
2007年 | 629篇 |
2006年 | 623篇 |
2005年 | 549篇 |
2004年 | 449篇 |
2003年 | 305篇 |
2002年 | 247篇 |
2001年 | 140篇 |
2000年 | 115篇 |
1999年 | 96篇 |
1998年 | 101篇 |
1997年 | 86篇 |
1996年 | 76篇 |
1995年 | 70篇 |
1994年 | 75篇 |
1993年 | 54篇 |
1992年 | 32篇 |
1991年 | 32篇 |
1990年 | 37篇 |
1989年 | 33篇 |
1988年 | 14篇 |
1987年 | 16篇 |
1986年 | 17篇 |
1985年 | 22篇 |
1984年 | 14篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 13篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
121.
《Autoimmunity》2013,46(8):692-698
Background: Immune thrombocytopenia (ITP) is an immune-mediated disorder in which destruction of platelets is accelerated by anti-platelet autoimmune antibodies. B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL), essential factors for B cell survival are elevated in systemic autoimmune diseases and correlated with clinical findings. High expression of BAFF has been shown in patients with ITP, but the status of APRIL in ITP is still unknown.Objective: To determine the expression of APRIL and it receptors, B-cell maturation antigen (BCMA) and trans-membrane activator and calcium modulator and cyclophilin ligand interactor (TACI), in patients with ITP, and evaluate the correlation between plasma APRIL levels and platelet accounts or other clinical parameters.Methods: Plasma samples from 57 patients with ITP, and 30 normal healthy subjects were assayed for APRIL plasma concentration by enzyme linked immunosorbent assay. Real-time quantitative polymerase chain reaction was performed to determine the mRNA expression of APRIL and its receptors (BCMA and TACI) in peripheral blood mononuclear cells (PBMNCs) in 25 normal controls and 34 untreated ITP patients with active disease.Results: The APRIL levels in the plasma samples from patients with ITP were significantly higher than those from healthy controls (p = 0.000). PBMNCs may be a source of the excess APRIL. Treated patients with normal platelet count have relatively normal plasma APRIL (p = 0.599). Plasma APRIL levels in active patients were significantly correlated with platelet counts (r = ? 0.387 and p = 0.024).Conclusion: APRIL is over expressed in untreated active ITP patients and might be a pathogenic factor of this disorder. 相似文献
122.
123.
124.
Wei-Chun Cheng Xi-Zhang Lin Chiung-Yu Chen 《Journal of the Chinese Medical Association》2013,76(7):395-400
BackgroundUpper abdominal sonography can help physicians to confirm the diagnosis of various hepatobiliary diseases. Teaching sonography skills to medical students is important because it may enhance their level of knowledge and overall development during their gastroenterology section rotation. Sonographic imaging is abstract and students can be easily confused when scanning the abdominal structures from different sites and directions. We used several modern teaching strategies to facilitate the learning of sonography skills.MethodsThe year five medical students beginning a gastroenterology section rotation for their first-year clerkship were taught abdominal sonography skills. Abstract sonographic images were related to concrete objects and the surrounding structures were further indicated. Each of the images was given a specific name and was sorted according to the scanning site. A mnemonics system was designed to help students to memorize the names of these images. A badge was created to recognize the achievement of being able to complete a basic upper abdominal sonography. Students were free (i.e., not obligated) to request a demonstration opportunity to show their skills within 2 weeks after receiving tutelage. We recorded the number of students who received training and were able to successfully complete the task; these individuals then received a badge to be pinned onto their white coats.ResultsSixty-three of 68 students (92.6%) requested evaluation and all of them passed.ConclusionWe have greatly simplified the process of learning about upper abdominal sonography by using andragogy to enhance learning, mnemonics to help memory, and a pin-badge reward system to stimulate incentives. 相似文献
125.
126.
哈得油田石炭系中泥岩段薄砂层油藏埋藏深、油层薄,且受岩性控制层状边水未饱和,采用以地质导向为基础的双台阶水平井钻井技术。 为了对双台阶水平井钻井质量进行有效评价,研制了一套完善的双台阶水平井钻井实时跟踪系统。该系统充分结合导眼井及邻井的地质、钻井、录井、测井及随钻测井等多种资料,实现双台阶水平井钻井的实时跟踪,对井眼轨迹位移及钻遇地层进行实时分析,计算钻遇率。利用该系统在哈得油田某井区双台阶水平注水井HD10-HX井现场进行了初步的钻井实时跟踪分析应用,获得了较好的应用效果。 相似文献
127.
128.
129.
《Molecular and cellular probes》2014,28(5-6):246-250
Foodborne disease caused by pathogenic Vibrio parahaemolyticus has become a serious public health problem in many countries. Rapid diagnosis and the identification of pathogenic V. parahaemolyticus are very important in the context of public health. In this study, an EvaGreen-based multiplex real-time PCR assay was established for the detection of pathogenic V. parahaemolyticus. This assay targeted three genetic markers of V. parahaemolyticus (species-specific gene toxR and virulence genes tdh and trh). The assay could unambiguously identify pathogenic V. parahaemolyticus with a minimum detection limit of 1.4 pg genomic DNA per reaction (concentration giving a positive multiplex real-time PCR result in 95% of samples). The specificity of the assay was evaluated using 72 strains of V. parahaemolyticus and other bacteria. A validation of the assay with clinical samples confirmed its sensitivity and specificity. Our data suggest the newly established multiplex real-time PCR assay is practical, cost-effective, specific, sensitive and capable of high-throughput detection of pathogenic V. parahaemolyticus. 相似文献
130.